Antibacterial and Antifungal Potential of Methanol Stem–Bark Extract of Mangifera Indica
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27-42
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Jul 16, 2024
Digital Object Identifier:
10.58578/ajstm.v1i1.3360
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Authors:
Kerenhappuch Isaac Umaru1, Akafa Andes Tansaba2, Egeonu Stephen Ugoeze3, Chakfa Nanmar4, Isaac John Umaru5 
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Main Article Content
Abstract
Medicinal plants have served through the ages, as a constant source of medicaments for the exposure of variety of diseases. The history of herbal medicine is as old as human civilization. The plants are known to provide a rich source of botanical anthelmintic, antibacterial and insecticides. Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. In antibacterial analysis, higher growth inhibition rate was observed at 400 ug/ml for Klebsiella pneumonia with 20.55 + 1.26μg/mL indicating that the extract has effect at a higher concentration than when treated at a lower concentration. In blood glucose level analysis, administration of 100 mg/kg body weight of Mangifera indica stem bark methanolic extract showed reduced blood glucose level in day 14 with 5.11 ± 0.14a of treatment when compared to normal control.
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How to Cite
Umaru, K. I., Tansaba, A. A., Ugoeze, E. S., Nanmar, C., & Umaru, I. J. (2024). Antibacterial and Antifungal Potential of Methanol Stem–Bark Extract of Mangifera Indica. African Journal of Sciences and Traditional Medicine, 1(1), 27-42. https://doi.org/10.58578/ajstm.v1i1.3360
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
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Dorta, E., Lobo, M.G. and Gonzalez, M. (2012). Reutilization of mango by‐products: Study of the effect of extraction solvent and temperature on their antioxidant properties. Journal of Food Science, 71, 80–88.
Barreto, J.C., Trevisan, M.T.S., Hull, W.E., Erben, G., de Brito, E.S. et al. (2008). Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agricultural and Food Chemistry, 56, 5599–5610.
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Cheema, S. and Sommerhalter, M. (2015). Characterization of polyphenol oxidase activity in Ataulfo mango. Food Chemistry, 171, 382–387.
Schieber, A., Ullrich, W. and Carle, R. (2000) Characterization of polyphenols in mango puree concentrate by HPLC with diode array and mass spectrometric detection. Innovative Food Science and Emerging Technologies, 1, 161–166.
Grundhofer, P., Niemetz, R., Schilling, G. and Gross, G. (2001). Biosynthesis and subcellular distribution of hydrolyzable tannins. Phytochemistry, 57, 915–927.
Palafox‐Carlos, H., Yahia, E. Islas‐Osuna, M.A., Gutierrez‐Martinez, P., Robles‐ Sánchez, M. and González‐Aguilar, G.A. (2012) Effect of ripeness stage of mango fruit (Mangifera indica L., cv. Ataulfo) on physiological parameters and antioxidant activity. Scientia Horticulturae, 135, 7–13.
Kim, Y., Lounds‐Singleton, A.J. and Talcott, S.T. (2009). Antioxidant phytochemical and quality changes associated with hot water immersion treatment of mangoes (Mangifera indica L.). Food Chemistry, 115, 989−993.
Robles‐Sánchez, R.M., Islas‐Osuna, M.A., Astiazaran‐Garcia, H., Vazquez‐Ortiz, F.A., Martin‐Belloso, O. et al. (2009a). Quality index consumer acceptability, bioactive compounds, and antioxidant activity of fresh‐cut Ataulfo mangoes (Mangifera indica L.) as affected by low‐temperature storage. Journal of Food Science, 74, S126–S134.
Robles‐ Sánchez, R.M., Rojas‐Grau, M.A., Odriozola‐Serrano, I., Gonzalez‐Aguilar, G.A. and Martin‐Belloso, O. (2009b) Effect of minimal processing on bioactive compounds and antioxidant activity of fresh‐cut “Kent” mango (Mangifera indica L.). Postharvest Biology and Technology. 51, 384–390.
Acosta J, Sevilla I, Salomon S, Nuevas L, Romero A, Amaro D. (2016). Determination of magniferin solubility in solvents used in the Biopharmaceutical University. Journal of Pharmaceutical Pharmacognosy. Research. 4(2): 49-53
Okwu, D. E. and Ezenagu, V. (2005). eval__uation of the Phytochemical Composition of Mango (Mangifera indica Linn) Stem Bark and Leaves. International Journal of Chemical Sciences. 6(2):705–716
Zhao, Y., Wang, W., Wu, X., Ma, X., Qu, R., Chen, X., Liu, C., Liu, Y., Wang, X., Yan, P., Zhang, H., Pan, J., Li, W. (2017). Mangiferin antagonizes TNF-α-mediated inflam- matory reaction and protects against dermatitis in a mice model. International Immunopharmacology. 45: 174-179.
Zhang, Y., Li, J., Wu, Z., Liu, E., Shi, P., Han, L., Guo, L., Gao, X., Wang, L. (2014). Acute and long-term toxicity of mango leaves extract in mice and rats. Evidence-Based Complementary and Alternative Medicine. 2014, Article ID 691574 http://dx.doi.org/10.1155/2014/691574.
Gold-Smith, F., Fernandez, A., Bishop, K. (2016). Mangiferin and cancer: Mechanisms of action. Nutrients. Jun 28; 8 (7). pii: E396. doi: 10.3390/nu8070396
Umaru, I. J., Badruddin, F. A., & Umaru, H. A. (2018). Gastroprotective Effect of Leptadenia Hastata (Pers.) Decne and Histopathological Changes on Indomethacin-Induced Gastric Ulcer in Rats. International Journal of Pure and Applied Biosciences. 6(5), 20-27.
Hugo W.B. (1998). Bacteria. In: Pharmaceutical microbiology. Hugo, W. B. and Russell, A. D. (eds.). Oxford, Blackwell Scientifc Publications
Masibo M. and He Q. (2009). In vitro antimicrobial activity and the major polyphenol in leaf extract of mangifera indica L. Malaysian Journal of Microbiology. Vol 5(2) p.73-80
Qudsia, K., Ishtiaq, H. and Arshad, J. (2009) Flavonoids from Mango Leaves with Antibacterial Activity. Journal of the Serbian. Chemical Society. 74 (12) 1389–1399.11. Mayura AK, Suparma MB, Pratima K. Role of antioxidants and nutrition in oxidative stress. International Journal of Pure and Applied Chemistry. 2015; 7:1-4.
Ficker CE, Arnason JT, Vindas PS, Alvarez LP, Akpagana K, Gbeassor M, Smith ML. (2003). Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses.46(1-2):29-37.
Umaru IJ, Badruddin FA, Umaru HA, Umaru KI. (2018b). Antifungal potential of some medicinal plants on selected pathogenic fungi. MOJ Proteomics & Bioinformatics.7(5):271‒276.
Boyan B, James H, Judicael P. (2005). Principles of accessing bacterial susceptibility to antibiotics using agar diffusion method. Journal of Antimicrobial Chemotherapy.61:1295- 1301.
Prashanth VK, Chauhan NS, Padh H, Rajani M. (2006). Search for antibacterial and antifungal agents from selected Indian medicinal plants. Journal of Ethnopharmacology. 107(2):182-188.
Runyoro DK, Matee MI, Ngassapa OD, Joseph CC, Mbwambo ZH. (2006). Screening of Tanzanian medicinal plants for anti-candida activity. BMC Complementary and Alternative Medicine.6(1):11.
Apu AS, Muhit MA, Tareq SM, Pathan AH, Jamaluddin ATM, Ahmed M. (2010). Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of Dillenia indica Linn. Journal of Young Pharmacists. 2(1):50-53.
Opawale BO, Onifade KA, Ogundare AO. (2011). Antimicrobial, free radical scavenging and cytotoxic activity of Khaya grandifolia C.CD extracts. Malaysian Journal of Microbiology.12(3):233-238.
Ihsan-Ul-Haq A, Ahmed I, Hussain I, Jamil M, Mirza B. (2012). Antibacterial activity and brine shrimp toxicity of Artemisia dubia extract. Pakistan Journal of Botany. 44(4):1487-1490.
Y. Prado, N. Merino, J. Acosta, J.A. Herrera, Y. Luque, I. Hernández, E. Prado, G. Garrido, R. Delgado, I. Rodeiro. (2015). Acute and 28-day subchronic toxicity studies of mangiferin, a glucosyl xanthone isolated from Mangifera indica L. stem bark. Journal of Pharmacy and Pharmacognosy Research. 3: 13-23.
Satyavati, G.V., Raina, M.K., Sharma, M. (1976). Medicinal Plants of India, Indian Council of Medical Resea. Sharmarch. 1: 201–206.
Acevedo, L.M, Raya, A.I., Martinez-Moreno, J.M. (2017). Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats. PLoS One; 12(3): e0173028.
Lewis, W.H. and Elvin- Lewis, M.P.H. (1977). Medicinal Botany Plants Affecting Man’s Health. John Wiley and Sons, New York.
Jouad, H., Haloui, M. and Rhiouani, H. (2001). Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez Boulemane). Journal of Ethnopharmacology. 77(2-3):175–182
Ajila, C.M., Naidu, K.A., Bhat, S.G. and Prasada Rao, U.J.S. (2007). Bioactive compounds and antioxidant potential of mango peel extract. Food Chemistry, 105, 982–988.
Dorta, E., Lobo, M.G. and Gonzalez, M. (2012). Reutilization of mango by‐products: Study of the effect of extraction solvent and temperature on their antioxidant properties. Journal of Food Science, 71, 80–88.
Barreto, J.C., Trevisan, M.T.S., Hull, W.E., Erben, G., de Brito, E.S. et al. (2008). Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agricultural and Food Chemistry, 56, 5599–5610.
Abdalla, A.E.M., Darwish, S.M., Ayad, E.H.E. and El‐Hamahmy, R.M. (2007). Egyptian mango by‐product: Compositional quality of mango seed kernel. Food Chemistry, 103, 1134–1140.
Cheema, S. and Sommerhalter, M. (2015). Characterization of polyphenol oxidase activity in Ataulfo mango. Food Chemistry, 171, 382–387.
Schieber, A., Ullrich, W. and Carle, R. (2000) Characterization of polyphenols in mango puree concentrate by HPLC with diode array and mass spectrometric detection. Innovative Food Science and Emerging Technologies, 1, 161–166.
Grundhofer, P., Niemetz, R., Schilling, G. and Gross, G. (2001). Biosynthesis and subcellular distribution of hydrolyzable tannins. Phytochemistry, 57, 915–927.
Palafox‐Carlos, H., Yahia, E. Islas‐Osuna, M.A., Gutierrez‐Martinez, P., Robles‐ Sánchez, M. and González‐Aguilar, G.A. (2012) Effect of ripeness stage of mango fruit (Mangifera indica L., cv. Ataulfo) on physiological parameters and antioxidant activity. Scientia Horticulturae, 135, 7–13.
Kim, Y., Lounds‐Singleton, A.J. and Talcott, S.T. (2009). Antioxidant phytochemical and quality changes associated with hot water immersion treatment of mangoes (Mangifera indica L.). Food Chemistry, 115, 989−993.
Robles‐Sánchez, R.M., Islas‐Osuna, M.A., Astiazaran‐Garcia, H., Vazquez‐Ortiz, F.A., Martin‐Belloso, O. et al. (2009a). Quality index consumer acceptability, bioactive compounds, and antioxidant activity of fresh‐cut Ataulfo mangoes (Mangifera indica L.) as affected by low‐temperature storage. Journal of Food Science, 74, S126–S134.
Robles‐ Sánchez, R.M., Rojas‐Grau, M.A., Odriozola‐Serrano, I., Gonzalez‐Aguilar, G.A. and Martin‐Belloso, O. (2009b) Effect of minimal processing on bioactive compounds and antioxidant activity of fresh‐cut “Kent” mango (Mangifera indica L.). Postharvest Biology and Technology. 51, 384–390.
Acosta J, Sevilla I, Salomon S, Nuevas L, Romero A, Amaro D. (2016). Determination of magniferin solubility in solvents used in the Biopharmaceutical University. Journal of Pharmaceutical Pharmacognosy. Research. 4(2): 49-53
Okwu, D. E. and Ezenagu, V. (2005). eval__uation of the Phytochemical Composition of Mango (Mangifera indica Linn) Stem Bark and Leaves. International Journal of Chemical Sciences. 6(2):705–716
Zhao, Y., Wang, W., Wu, X., Ma, X., Qu, R., Chen, X., Liu, C., Liu, Y., Wang, X., Yan, P., Zhang, H., Pan, J., Li, W. (2017). Mangiferin antagonizes TNF-α-mediated inflam- matory reaction and protects against dermatitis in a mice model. International Immunopharmacology. 45: 174-179.
Zhang, Y., Li, J., Wu, Z., Liu, E., Shi, P., Han, L., Guo, L., Gao, X., Wang, L. (2014). Acute and long-term toxicity of mango leaves extract in mice and rats. Evidence-Based Complementary and Alternative Medicine. 2014, Article ID 691574 http://dx.doi.org/10.1155/2014/691574.
Gold-Smith, F., Fernandez, A., Bishop, K. (2016). Mangiferin and cancer: Mechanisms of action. Nutrients. Jun 28; 8 (7). pii: E396. doi: 10.3390/nu8070396
Umaru, I. J., Badruddin, F. A., & Umaru, H. A. (2018). Gastroprotective Effect of Leptadenia Hastata (Pers.) Decne and Histopathological Changes on Indomethacin-Induced Gastric Ulcer in Rats. International Journal of Pure and Applied Biosciences. 6(5), 20-27.
Hugo W.B. (1998). Bacteria. In: Pharmaceutical microbiology. Hugo, W. B. and Russell, A. D. (eds.). Oxford, Blackwell Scientifc Publications
Masibo M. and He Q. (2009). In vitro antimicrobial activity and the major polyphenol in leaf extract of mangifera indica L. Malaysian Journal of Microbiology. Vol 5(2) p.73-80
Qudsia, K., Ishtiaq, H. and Arshad, J. (2009) Flavonoids from Mango Leaves with Antibacterial Activity. Journal of the Serbian. Chemical Society. 74 (12) 1389–1399.11. Mayura AK, Suparma MB, Pratima K. Role of antioxidants and nutrition in oxidative stress. International Journal of Pure and Applied Chemistry. 2015; 7:1-4.
Ficker CE, Arnason JT, Vindas PS, Alvarez LP, Akpagana K, Gbeassor M, Smith ML. (2003). Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses.46(1-2):29-37.
Umaru IJ, Badruddin FA, Umaru HA, Umaru KI. (2018b). Antifungal potential of some medicinal plants on selected pathogenic fungi. MOJ Proteomics & Bioinformatics.7(5):271‒276.
Boyan B, James H, Judicael P. (2005). Principles of accessing bacterial susceptibility to antibiotics using agar diffusion method. Journal of Antimicrobial Chemotherapy.61:1295- 1301.
Prashanth VK, Chauhan NS, Padh H, Rajani M. (2006). Search for antibacterial and antifungal agents from selected Indian medicinal plants. Journal of Ethnopharmacology. 107(2):182-188.
Runyoro DK, Matee MI, Ngassapa OD, Joseph CC, Mbwambo ZH. (2006). Screening of Tanzanian medicinal plants for anti-candida activity. BMC Complementary and Alternative Medicine.6(1):11.
Apu AS, Muhit MA, Tareq SM, Pathan AH, Jamaluddin ATM, Ahmed M. (2010). Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of Dillenia indica Linn. Journal of Young Pharmacists. 2(1):50-53.
Opawale BO, Onifade KA, Ogundare AO. (2011). Antimicrobial, free radical scavenging and cytotoxic activity of Khaya grandifolia C.CD extracts. Malaysian Journal of Microbiology.12(3):233-238.
Ihsan-Ul-Haq A, Ahmed I, Hussain I, Jamil M, Mirza B. (2012). Antibacterial activity and brine shrimp toxicity of Artemisia dubia extract. Pakistan Journal of Botany. 44(4):1487-1490.