Potential of Aqueous Leaves Extract of Jatropha Gossypiifolia Seed Against Highly Active Antiretroviral Therapy Induced Hepatotoxicity in Rats
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62-77
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10.58578/ajstm.v2i2.5182
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Authors:Isaac John Umaru1, Tensaba Andes Akafa2, Ingwu Joseph Akem33, Joseph Oteng4, Ocheifa Mathew Ngbede5, Ashaka Fidelis Utioukpan6, Aboki Nwunuji Mijinyawa7, Odok Endurance Akam8, Ogholo Ogholo Ekup9
Copyright :Authors retain copyright and grant the journal right of first publication.
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Abstract
While many methods exist for measuring the impact of AIDS, treatment remedy the human development approach focuses on people rather than medical or economic indicators. Human Development Index captures three basic dimensions of human development: a long and healthy life—measured by life expectancy at birth; knowledge—measured by adult literacy and school enrolment; and standard of living—measured by per capita gross domestic product. Thus, investigate the hepatoprotective activity of aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy administered rats. Liver is a metabolically active organ responsible for many vital life functions. It performs many activities that are critical for survival. Due to its important activities, the liver is exposed to a number of insults and is one of the body's organs most subject to injury. In spite of tremendous advances in modern medicine, there are hardly any reliable drugs that protect the liver from damage and/or help in regeneration of hepatic cell. It is, therefore, necessary to search for effective and safe herbal drugs for the treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Hence, the need to evaluate the aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy (Lamivudine, Zidovudine and Efavirenz) administered rats. Sixty rats weighed between 150-200g were randomly divided into six groups and each group comprised of ten rats. Rats in group I were administered with distilled water. Rats in group II were administered with highly active antiretroviral therapy only. Rats in groups III - VI were administered 100, 200, 400 and 600 mg/kg Jatropha gossypiifolia seed plus highly active antiretroviral therapy respectively. The treatments were given orally for 28 consecutive days. On the 29th day, all rats were sacrificed under light diethyl ether anaesthesia; blood samples were collected for the assessment of biochemical parameters, while Serum levels of liver enzymes ALT, AST, ALP, and GGT were significantly (p<0.05) increased and albumin concentration was significantly decreased in animals treated with highly active antiretroviral therapy as compared to the normal control. Treatment of highly active antiretroviral therapy exposed animals with Jatropha gossypiifolia seed showed marked improvement in biochemical findings. Rise in liver enzymes was almost restored to normal in animals treated with Jatropha gossypiifolia seed. Jatropha gossypiifolia seed through its antioxidant activity effectively protects highly active antiretroviral therapy induced liver toxicity.
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References
2. Sidibé, M. HIV/AIDS Branch and the Gender, Human Rights and Culture Branch of the United Nations Population Fund (UNFPA), under the coordination and direction of Lynn Collins, Technical Adviser in the HIV/AIDS Branch.
3. Mann, M., Shelhamer, J. H., Masur, H., Gill, V. J., Travis, W., Solomon, D., ... & Ognibene, F. P. (1997). Lack of clinical utility of bronchoalveolar lavage cultures for cytomegalovirus in HIV infection. American journal of respiratory and critical care medicine, 155(5), 1723-1728.
4. De Waal, A., & Whiteside, A. (2003). New variant famine: AIDS and food crisis in southern Africa. The Lancet, 362(9391), 1234-1237.
5. Barnett, T., & Whiteside, A. (2002). Poverty and HIV/AIDS: impact, coping and mitigation policy. AIDS, public policy and child well-being.
6. Bell, N. M., & Lever, A. M. (2013). HIV Gag polyprotein: processing and early viral particle assembly. Trends in microbiology, 21(3), 136-144.
7. Ahsan R, Islam KM, Musaddik A, et al. Hepatoprotective Activity of Methanol Extract of Some Medicinal Plants against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats. Global Journal of Pharmacology 2009; 3(3):116-122
8. Panda BB, Gaur K, Nema RK, et al. Hepatoprotective Activity of Jatropha Gossypifolia Against Carbon Tetrachloride Induced Hepatic Injury in Rats. Asian Journal of Pharmaceutical and Clinical Research 2009; 2(1):50-54
9. Kayode AA, Kayode OT, Aroyeun OA, et al. Hematologic and Hepatic Enzyme Alterations Associated with Acute Administration of Antiretroviral Drugs, Journal of Pharmacology and Toxicology 2011; 6(3):293-302
10. Barrose E. Interaction of Traditional Remedies against HIV, Nutrients and ARVs, Recent Translational Research in HIV/AIDS 2011; 1:111-126
11. Aranzabal L, Casado JL, Moya J, et al. Antiretroviral Therapy–Associated Hepatotoxicity in Patients with HIV and Hepatitis C Virus Coinfection. Clinical Infectious Diseases 2005; 40:588–93
12. Setzer B, Lebrecht D, Walker UA. Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine. The American Journal of Pathology 2008; 172(3): 681–690
13. Labarga P, Soriano V, Vispo ME, et al. Hepatotoxicity of Antiretroviral Drugs Is Reduced after Successful Treatment of Chronic Hepatitis C in HIV-Infected Patients. The Journal of Infectious Diseases 2007; 196:670–676
14. Manfredi R, Calza L, Chiodo F. Prospective, Open-Label Comparative Study of Liver Toxicity in an Unselected Population of HIV infected patients treated for the first time with Efavirenz or Nevirapine. HIV Clinical Trials 2005; 6(6):302–311
15. Ocama P, Katwere M, Piloya T, et al. The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. African Health Sciences 2008; 8(1): 8-12.
16. Panda BB, Gaur K, Nema RK, et al. Hepatoprotective Activity of Jatropha Gossypifolia Against Carbon Tetrachloride Induced Hepatic Injury in Rats. Asian Journal of Pharmaceutical and Clinical Research 2009; 2(1):50-54
17. Michel CG, El-Dine NS, Fahmy SM, et al. Phytochemical and biological investigation of the extracts of N. sativa L. seed waste. Drug Testing and Analysis 2010; 1:1-10
18. Dehkordi FR, Kamkhah AF. Antihypertensive effect of N. sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology 2008; 22:447–452
19. Khan FA, Hussain I, Farooq Sh, et al. Phytochemical Screening of Some Pakistanian Medicinal Plants. Middle- East Journal of Scientific Research 2011; 8(3): 575-578
20. Tiwari P, Kumar B, Kaur M, et al. Phytochemical screening and Extraction: A Review. Internationale Pharmaceutica Sciencia, an International Peer Reviewed Journal 2011; 1(1):98-106
21. Savithramma N, Linga Rao M, Suhrulatha D. Screening of Medicinal Plants for Secondary Metabolites. Middle-East Journal of Scientific Research 2011; 8(3): 579-584
22. Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. African Journal of Biotechnology 2005; 4(7):685-688
23. Gabriel O, Harrision N, Okey O, et al. Changes in Lipid and Haematological profile of aqueous ethanolic extract of Alstonia boonei in rats. The internet journal of Haematology 2008; 4:1-5
24. Panda BB, Gaur K, Nema RK, et al. Hepatoprotective Activity of Jatropha Gossypifolia Against Carbon Tetrachloride Induced Hepatic Injury in Rats. Asian Journal of Pharmaceutical and Clinical Research 2009; 2(1):50-54
25. Gaskill C, Miller L, Matton J, et al. Liver Histopathology and Serum ALT and ALP activities in Epileptic Dogs receiving phenobarbital. Journal of Veterinary pathology 2005; 87:155-161
26. Kayode AA, Kayode OT, Aroyeun OA, et al. Hematologic and Hepatic Enzyme Alterations Associated with Acute Administration of Antiretroviral Drugs, Journal of Pharmacology and Toxicology 2011; 6(3):293-302
27. Haldar P, Gupta M, Mazumder U, et al. Hepatoprotective effect of Wedelia calendulacea against Thioacetamide induced liver damage in rats. Journal of Pharmacology 2007; 3:414-42136.
28. Gani AMS, John SA. Evaluation of Hepatoprotective effect of N. sativa L. International Journal of Pharmacy and Pharmaceutical Sciences 2013; 5(4):428-430
29. Parmar SR, Vashrambhai PH, Kalia K. Hepatoprotective Activity of some plants extract against Paracetamol induced Hepatotoxicity in Rats. Journal of Herbal Medicine and Toxicology 2010; 4(2): 101-106
30. Sule OJ, Godwin J, Nnopu IA. Biochemical Investigation of Hepatotoxic effects of Antiretroviral Drugs on Wistar Albino Rats, Journal of Physiology and Pharmacology Advances 2012; 2(4): 171-175
31. Tietz N.W., editor. Text book of Clinical Chemistry.3rd edition, Philadelphia: WB Saunders 2001
32. Michel CG, El-Dine NS, Fahmy SM, et al. Phytochemical and biological investigation of the extracts of N. sativa L. seed waste. Drug Testing and Analysis 2010; 1:1-10
33. Rosalki SB, Mcintyre N. Biochemical investigations in the management of liver disease. In: Oxford textbook of clinical hepatology, 2nd edition. New York; Oxford university press 1999; 503-521.
34. Ahsan R, Islam KM, Musaddik A, et al. Hepatoprotective Activity of Methanol Extract of Some Medicinal Plants against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats. Global Journal of Pharmacology 2009; 3(3):116-122
35. Parmar SR, Vashrambhai PH, Kalia K. Hepatoprotective Activity of some plants extract against Paracetamol induced Hepatotoxicity in Rats. Journal of Herbal Medicine and Toxicology 2010; 4(2): 101-106
36. Essawy AE, Abdel-Moneim AM, Khayyat LI, et al. N. sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice. Journal of Applied Pharmaceutical Science 2012; 2(10):021-025
37. Yahya F, Mamat SS, Kamarolzaman MFF, et al. Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats. Evidence-Based Complementary and Alternative Medicine 2013; 1:1-11