Hypoglycaemic Potential of Methanol Stem-Bark Extract of Mangifera Indica in Alloxan Induced Diabetic Albino Rats and Its Toxicity Effect to Liver and Kidney
Article Sidebar
Page Numbers:
1-15
Digital Object Identifier:
10.58578/ajstm.v1i1.3358
Viewed: 914 times
Downloaded: 257 times
LYAS Publisher cordially invites qualified professionals to serve as Editors or Reviewers. Your expertise will make an important contribution to maintaining and strengthening the academic quality of our publications. Interested applicants are kindly requested to complete the application form at the following link: Editors & Reviewers
Please feel free to contact us if you need any further information about the submission process or if you have any additional questions.
Authors:
Isaac John Umaru1, Nkiri Annasthesia Ekubnse2, Kerenhappuch Isaac Umaru3, Akafa Andes Tansaba4, Egeonu Stephen Ugoeze5, Chakfa Nanmar6 
Copyright :
Authors retain copyright and grant the journal right of first publication.
Main Article Content
Abstract
Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. Mango possesses anti-diabetic, anti-bacterial, anti- oxidant, anti-viral and anti-inflammatory properties. This research focuses on the hyperglycemic and antibacterial capacity of methanol stem bark extract of Mango tree in alloxan induced diabetic albino rats to combat its fatal consequences in humans. This work is carried out to determine the hypoglycemic capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration, to also determine the antibacterial capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration and to test the efficacy of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats. Fresh stem bark (trunk) of Mangifera indica were collected in the Federal University Wukari school premises, were air dried for 21 days, pounded into powder, cold macerated in methanol, filtered and extract was gotten. 27 diseased-free (healthy) albino rats which were purchased at Yola, Adamawa State, were kept in different cages to enable proper analysis at the cause of the work. Results of liver function indices showed that treatments with 100 mg/kg, 200mg/kg and 400mg/kg body weight of Mangifera indica stem bark methanolic extract were able to restore liver function parameters at different levels of concentrations. Treatments with standard drug and all the doses of the extract were able to counteract the elevated effect of alloxan in some kidney parameters such as serum urea level at 200mg/kg with (25.23±1.98a) and (1.05 ±0.14a) for creatinine at 200mg/kg respectively. The result of this study shows that the stem back extract possessed as an agent for hypoglycaemic. These can serve as possible source of raw material for pharmaceutical products. However, the extract is found not to be harmful to the liver and kidney and should be used as health remedy for certain diseases such as hyperglycaemic and bacterial effects.
Citation Metrics:
Downloads
Article Details
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
Lewis, W.H. and Elvin- Lewis, M.P.H. (1977). Medicinal Botany Plants Affecting Man’s Health. John Wiley and Sons, New York.
World Health Organization; https://www.who.int/medacenter/factsheets/fs/138/en/Page1-3
Ikebukuro, K., Adachi, Y., Yamada, Y., Fujimoto, S., Seino, Y. and Oyaizu, H. (2002). Treatment of Alloxan-induced diabetes mellitus by transplantation of islet cells plus bone Marrow cells via portal vein in rats. Transplantation. 73 (4): 512-8
Solís-Fuentes, J. A. and Durán-de-Bazúa, M. C. (2011). Mango (Mangifera indica L.) seed and its fats.
Okwu, D. E. and Ezenagu, V. (2005). eval____uation of the Phytochemical Composition of Mango (Mangifera indica Linn) Stem Bark and Leaves. International Journal of Chemical Sciences. 6(2):705–716
Jouad, H., Haloui, M. and Rhiouani, H. (2001). Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez Boulemane). Journal of Ethnopharmacology. 77(2-3):175–182
Vivek, K.S. (2010). Alloxan: an experimental tool in diabetes and alzheimer’s disease (A- Review). International Journal of Research and Development in Pharmacy. 2(1):1–7
Eleazu (2013). Review of the mechanism of cell death resulting from alloxan challenge in experimental animals, its practical use and potential risk to humans. Journal of Diabetes & Metabolic Disorders, 12:60
Akbarzadeh, A. (2007). Induction of Diabetes by Alloxan In Rats. Indian Journal of Clinical Biochemistry. 22 (2) 60-64
Bolzan, A.D., Bianchi, M.S. (2002). Genotoxicity of Alloxan. Mutation Research. 512:121–134.
Szkudelski, T. (2001). The Mechanism of Alloxan and Alloxan Action in B Cells of the Rat Pancreas. Physiological Research. 50: 536-546.
Adam, Z., Khamis, S., Ismail, A., Hamid, M. (2012). Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 1-12.
Krisanapun, C., Peungvicha, P., Temsiririrkkul, R., Wongkrajang, Y. (2009). Aqueous Extract of Abutilon indicum Sweet Inhibits Glucose Absorption and Stimulates Insulin Secretion in Rodents. Nutrition Research. 29(8):579-87.
Ramakrishnan, P., Ramadoss, D., Muthulingam, P., Nedunchezhian, R., Krishnamoorthy, K. (2017). Antidiabetic, Antihyperlipidemic, Antioxidant Property of Cordia obliqua on Alloxan Induced Diabetic Rats. Journal of Young Pharmacists. 9(3):321-6.
Ghasemi, A.S., Khalifi, S., Jedi, S. (2014). Alloxan-nicotinamide-induced rat model of type 2 diabetes. Acta Physiological Hungarica. 101(4):408-20.
Adedosu, O.T., Jimoh, R.A. and Saraki, M.A. (2019) Ethanol leaves extract of Mangifera indica (L) exhibits protective, antioxidative, and antidiabetic effects in rats. Asian Pacifc Journal of Health Sciences. 5(1):188–194.
Luka, C.D. and Mohammed, A. (2012). eval____uation of the antidiabetic property of aqueous extract of Mangifera indica leaf on normal and alloxan‐induced diabetic rats. Journal of Natural Product and Plant Resources, 2, 239–243.
Galighor, A.E. and Kozloff, E.N. (1976). Essentials of practical Micro Technique. 2nd edi. New York: Lea and Fibiger
Esmaeili, A.H., Khavari-Nejad, R.A, Hajizadehmoghaddam, A., Chaichi, M.and Ebrahimzadeh, M. (2012). Effects of eriobotrya japonica (Lindl.) flower extracts on mercuric chloride-induced hepatotoxicity in rats. Chinese Science Bulletin; 57:3891-3897.
Iseghohi, S.O, Orhue, N.E. and Omage, K. (2017). Ethanolic extract of Dennettia tripetala fruits protects the liver and kidney of rats from damage induced by a single exposure to carbon tetrachloride. IJPPE. 2017; 6:8–16.
Kovesdy, C.P. (2014). Management of hyperkalaemia in chronic kidney disease. Natute Reviews Nephrology. 10(11):653-62.