Review of Epigenetics of Folate and Associated Derangements
Article Sidebar
Page Numbers:
320-341
Published:
Oct 23, 2025
Digital Object Identifier:
10.58578/ajstm.v2i3.7707
Article Metrics:
Viewed: 51 times
Downloaded: 30 times
Article can trace at:
Author Fee:
Free Publication Fees for Foreign Researchers (0.00)
Check for article on SINTA:
We cordially invite qualified professionals to join LYAS Publisher as Editors or Reviewers. Your expertise will contribute significantly to maintaining the quality of our publications. If you are interested, please complete the following form: Call for Editors & Reviewers
Connected Papers:
Please feel free to contact us if you need more information about the submission process or have any further questions.
Authors:
K. A. Ahmad1, A. U. Wurochekke2 
Copyright :
Authors retain copyright and grant the journal right of first publication.
Main Article Content
Abstract
Folate, a vital water-soluble B vitamin, plays a central role in one-carbon metabolism, serving as a key donor of methyl groups necessary for DNA methylation—an essential epigenetic mechanism regulating gene expression. This review synthesizes current evidence on folate's role in epigenetic modulation, drawing from PubMed, Google Scholar, and other reputable sources. Particular attention is given to folate’s inverse association with cancer risk, especially colorectal cancer, and its influence on epigenetic processes such as DNA methylation and histone modifications. Dysregulation of these mechanisms is closely linked to carcinogenesis and other chronic non-communicable diseases. Moreover, mutations or deficiencies in folate-related proteins may result in aberrant epigenetic reprogramming, leading to altered transcriptional activity and increased disease susceptibility. This review underscores the critical importance of adequate folate status in maintaining epigenetic homeostasis and preventing the onset of various malignancies and chronic conditions.
Keywords:
Share Article:
Epigenetics; DNA Methylation; Histone Modifications; Malignancies; Transcription; Non-Communicable Chronic Diseases
Citation Metrics:
Downloads
Download data is not yet available.
Article Details
How to Cite
Ahmad, K. A., & Wurochekke, A. U. (2025). Review of Epigenetics of Folate and Associated Derangements. African Journal of Sciences and Traditional Medicine, 2(3), 320-341. https://doi.org/10.58578/ajstm.v2i3.7707
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
Abdar Esfahani, M., Servatian, N., Al-Athari, A. J. H., Khafaja, E. S. M., Rahmani Seraji, H., & Soleimani Samarkhazan, H. (2025). The epigenetic revolution in hematology: from benchside breakthroughs to clinical transformations. Clinical and Experimental Medicine, 25(1), 230.
Ahmad, F., Uzair, S. A., Lakshmanan, A. P., Alabduljabbar, S., Ahmed, S. H., Kabeer, B. S. A., Marr, A. K., Kino, T., Brummaier, T., & McGready, R. (2025). Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats. Molecular Nutrition & Food Research, e70058.
Alemu, R., Sharew, N. T., Arsano, Y. Y., Ahmed, M., Tekola-Ayele, F., Mersha, T. B., & Amare, A. T. (2025). Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues. Human Genomics, 19(1), 8.
Ali, S., & Tang, Y. (2025). Noncoding RNA-mediated regulation of DNA methylation: insights into plant epigenetic mechanisms. Journal of Plant Growth Regulation, 44(2), 373–388.
Ambrosio, S., Noviello, A., Di Fusco, G., Gorini, F., Piscone, A., Amente, S., & Majello, B. (2025). Interplay and dynamics of chromatin architecture and DNA damage response: An overview. Cancers, 17(6), 949.
An, Y., Wang, Q., Gao, K., Zhang, C., Ouyang, Y., Li, R., Ma, Z., Wu, T., Zhou, L., & Xie, Z. (2025). Epigenetic Regulation of Aging and its Rejuvenation. MedComm, 6(9), e70369.
Aquilino, M., Ditzer, N., Namba, T., & Albert, M. (2025). Epigenetic and metabolic regulation of developmental timing in neocortex evolution. Trends in Neurosciences.
Arachchillage, D. P. W., & Udomsinprasert, W. (2025). Long interspersed nuclear element 1 methylation in non-small cell lung cancer: implications for diagnosis, prognosis, and therapeutic targeting. Cell Communication and Signaling, 23(1), 350.
Araszkiewicz, A. F., Jańczak, K., Wójcik, P., Białecki, B., Kubiak, S., Szczechowski, M., & Januszkiewicz-Lewandowska, D. (2025). MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A Review. Genes, 16(4), 441.
Aswathy, V. J., & VR, S. (2025). AYURVEDA AND EPIGENETICS: FOUNDATIONS FOR PREVENTIVE AND PRECISION HEALTHCARE. Kottakkal Journal of Ayurvedic Medicine And Research, 1(3), 20–27.
Avram, O.-E., Bratu, E.-A., Curis, C., Moroianu, L.-A., & Drima, E. (2025). Modifiable Nutritional Biomarkers in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Vitamin D, B12, and Homocysteine Exposure Spanning Prenatal Development Through Late Adolescence. International Journal of Molecular Sciences, 26(9), 4410.
Ayoub, G. (2025). Vitamins, Vascular Health and Disease. Nutrients, 17(18), 2955.
Bakkar, M., Khalil, S., Bhayekar, K., Kushwaha, N. D., Samarbakhsh, A., Dorandish, S., Edwards, H., Dou, Q. P., Ge, Y., & Gavande, N. S. (2025). Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. Biomolecules, 15(2), 240.
Bakrim, S., El Omari, N., El Yaagoubi, O. M., Khalid, A., Abdalla, A. N., Hamza, S. M. A., Ibrahim, S. E., Atifi, F., Zaid, Y., & Bouyahya, A. (2025). Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights. Cell Biology and Toxicology, 41(1), 116.
Bartak, B. K., Nagy, Z. B., Szakallas, N., Kalmar, A., Farkas, E., Banyai, F., Pipek, O., Csabai, I., Sydo, N., & Csulak, E. (2025). Examination of Genetic and Epigenetic Characteristics of Patients with Hyperhomocysteinemia Following High-Dose Folic Acid Consumption. Nutrients, 17(13), 2133.
Bhasker, A., & Veleri, S. (2025). Fundamental origins of neural tube defects with a basis in genetics and nutrition. Experimental Brain Research, 243(4), 79.
Bidoli, C. (2025). In silico identification of predictive markers for precision medicine in pediatric diseases.
Blomgren, L. K. M. (2025). Defining the Structure-Function Relationship behind Allosteric Regulation of 5, 10-Methylenetetrahydrofolate Reductase. University of Zurich.
Brethouwer, T., de Mendoza, A., & Bogdanovic, O. (2025). Non-CG DNA methylation in animal genomes. Nature Genetics, 1–13.
Brown, L. T. L., Pereira, D., & Winn, L. M. (2025). A Narrative Review on the Effect of Valproic Acid on the Placenta. Birth Defects Research, 117(4), e2471.
Castillo, L. F., Pelletier, C. M., Heyden, K. E., & Field, M. S. (2025). New Insights into Folate–Vitamin B12 Interactions. Annual Review of Nutrition, 45.
Cerreto, G. M., Pozzi, G., Cortellazzi, S., Pasini, L. M., Di Martino, O., Mirandola, P., Carubbi, C., Vitale, M., & Masselli, E. (2025). Folate metabolism in myelofibrosis: a missing key? Annals of Hematology, 104(1), 35–46.
Chen, L., van der Veer, B. K., Chen, Q., Champeris Tsaniras, S., Brangers, W., Kwak, H. H. M., Khoueiry, R., Lei, Y., Cabrera, R., & Gross, S. S. (2025). The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development. EMBO Reports, 26(1), 175–199.
Clement, A., Viot, G., Elder, K., Clement, P., & Menezo, Y. J. R. (2025). Can some metabolic one-carbon cycle linked diseases be prevented? The impact of treating hypo-fertile couples carrying MTHFR SNPs with folic acid and 5-MTHF on outcomes in the offspring: a case retrospective series. Journal of Assisted Reproduction and Genetics, 42(2), 533–539.
Cohen, N. J., Lesseur, C., Cardenas, A., Ward-Caviness, C. K., Spring, A. C., Rager, J. E., Fry, R. C., & Eaves, L. A. (2025). Placental DNA methylation key topics: sex-and cell-type specificity, mediation, multi-omics, and biomarker discovery. Epigenomics, 17(13), 905–921.
Costa, S., La Rocca, G., & Cavalieri, V. (2025). Epigenetic regulation of chromatin functions by MicroRNAs and long noncoding RNAs and implications in human diseases. Biomedicines, 13(3), 725.
Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012). Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Advances in Nutrition (Bethesda, Md.), 3(1), 21–38. https://doi.org/10.3945/an.111.000992
Davie, J. R., Sattarifard, H., Sudhakar, S. R. N., Roberts, C.-T., Beacon, T. H., Muker, I., Shahib, A. K., & Rastegar, M. (2025). Basic Epigenetic Mechanisms. Neuroepigenetics Mechanisms in Health and Disease, 1–49.
Du, L., Gao, R., & Chen, Z. (2025). 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism. International Journal of Molecular Sciences, 26(6), 2560.
Dutta, S., Dutta, S., Somanath, P. R., Narayanan, S. P., Wang, X., & Zhang, D. (2025). Circulating nucleosomes and histones in the development of lung injury and sepsis. Current Issues in Molecular Biology, 47(2), 133.
Ediriweera, M. K., & Sandamalika, W. M. G. (2025). The epigenetic impact of fatty acids as DNA methylation modulators. Drug Discovery Today, 30(2), 104277.
Emre, S., Algin, A., & Toros, T. (2025). The Relationship Between Exercise and Sport and Epigenetics. Cuestiones de Fisioterapia, 54(3), 4859–4871.
Engin, A. B., & Engin, A. (2025). Nanoparticle Mediated Epigenetic and Immunological Modulation. In Nanosafety: A Comprehensive Approach to Assess Nanomaterial Exposure on the Environment and Health (pp. 87–114). Springer.
Fang, Z., Zhou, Y., Chen, K., Wang, J., Liu, X., & Jia, P. (2025). Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism. Frontiers in Neuroscience, 19, 1587818.
Fatima, N., Yaqoob, S., Rana, L., Imtiaz, A., Iqbal, M. J., Bashir, Z., Shaukat, A., Naveed, H., Sultan, W., & Afzal, M. (2025). Micro-nutrient sufficiency in mothers and babies: management of deficiencies while avoiding overload during pregnancy. Frontiers in Nutrition, 12, 1476672.
Fernández-Ramos, D., Lopitz-Otsoa, F., Lu, S. C., & Mato, J. M. (2025). S-adenosylmethionine: a multifaceted regulator in cancer pathogenesis and therapy. Cancers, 17(3), 535.
Fernandez, A. F., Assenov, Y., Martin-Subero, J. I., Balint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M., Tan, A.-C., Galm, O., Ferrer, I., Sanchez-Cespedes, M., Villanueva, A., Carmona, J., Sanchez-Mut, J. V, Berdasco, M., Moreno, V., Capella, G., Monk, D., … Esteller, M. (2012). A DNA methylation fingerprint of 1628 human samples. Genome Research, 22(2), 407–419. https://doi.org/10.1101/gr.119867.110
Flori, L., Veneziano, S., Martelli, A., Piragine, E., & Calderone, V. (2025). Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid. International Journal of Molecular Sciences, 26(13), 6430.
Frost, Z., Bakhit, S., Amaefuna, C. N., Powers, R. V, & Ramana, K. V. (2025). Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression. International Journal of Molecular Sciences, 26(5), 1967.
Gogineni, G. R., Kamireddy, S., Ramani, N. D., Parveen, S., & Kumar, A. R. (2025). A Comprehensive Review on Micro RNA In Medical Domain. International Symposium on Sustainable Drug Design and Nanoparticle Development: Quantum and Computational Perspectives (SDDNDQCP 2025), 378–392.
González-Ludlow, I., Rodríguez-Cano, A. M., Mendoza-Ortega, J. A., Rodríguez-Hernández, C., Suárez-Rico, B. V, Estrada-Gutierrez, G., Tolentino-Dolores, M., Parra-Hernández, S. B., Sánchez-Martínez, M., & Acevedo-Gallegos, S. (2025). Maternal folate and vitamin B 12 concentrations during pregnancy influence neonatal nutritional status and adiposity: results from the OBESO cohort. Nutrients, 17(3), 372.
Günçer, B., Özkök, F., Aldoğan, E. H., Oyacı, Y., Nazlıgül, E., Edis, B. Ö., Akbarzadeh, S., Onul, N., Akdemir, A., & Atalay, V. E. (2025). Synthesis, in-vitro, in-silico, and global DNA methylation studies of curcumin-benzoquinone analog in triple-negative breast cancer (TNBC) cells. Toxicology Research, 14(4), tfaf128.
Gunnala, S., Buhlman, L. M., & Jadavji, N. M. (2025). How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity. Nutrients, 17(7), 1286.
Hamdani, S., Hamijoyo, L., Amalia, R., & Barliana, M. I. (2025). Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review. Frontiers in Genetics, 16, 1594648.
IKE, P. C., ENYINNAYA, A. C., UJAM, C. G., AYINDE, M. K., GOLDEN, F. I., OLATOKUN, T. P., & NASIR, K. (2025). INVESTIGATING THE RELATIONSHIP BETWEEN NUTRITION AND DNA MARKERS ASSOCIATED WITH HEART HEALTH IN MIDDLE-AGED ADULTS WITH TYPE 2 DIABETES. International Journal of Convergent and Informatics Science Research.
Imran, K., Iqbal, M. J., Ahmed, M. M., Khalid, A., Cortés, H., Reyes-Hernández, O. D., Figueroa-González, G., Leyva-Gómez, G., Falzone, L., & Libra, M. (2025). Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies. Medical Oncology, 42(8), 359.
Jang, S., Choi, N., Park, J. H., & Yoo, K. H. (2025). Contribution of histone deacetylases (HDACs) to the regulation of histone and non-histone proteins: implications for fibrotic diseases. BMB Reports, 58(8), 313.
Jiao, P., Lu, H., Hao, L., Degen, A. A., Cheng, J., Yin, Z., Mao, S., & Xue, Y. (2025). Nutrigenetic and epigenetic mechanisms of maternal nutrition–induced glucolipid metabolism changes in the offspring. Nutrition Reviews, 83(4), 728–748.
Kapała, A., Różycka, K., & Dąbrowska-Bender, M. (2025). A clinical retrospective study—the investigation of folic acid concentration in caucasian cancer patients. Nowotwory. Journal of Oncology, 75(1), 1–9.
Kaya, C., & Adamakis, I.-D. S. (2025). Redox-Epigenetic Crosstalk in Plant Stress Responses: The Roles of Reactive Oxygen and Nitrogen Species in Modulating Chromatin Dynamics. International Journal of Molecular Sciences, 26(15), 7167.
Khatami, F., Bahri, R. A., Sharifkazemi, H., Sajadi, S. M., Shamshirgaran, A., & Le Calvez-Kelm, F. (2025). Molecular biology and epigenetic modifications definition. In Genetics and Epigenetics of Genitourinary Diseases (pp. 37–61). Elsevier.
Kim, D.-H. (2025). Epigenetic regulators and their involvement in the stress response of Arabidopsis plants: Emphasis on histone modifications and chromatin remodeling. Journal of Plant Biology, 1–22.
Krekora, J., Fila, M., Mitus-Kenig, M., Pawlowska, E., Ciupinska, J., & Blasiak, J. (2025). Sirtuins Contribute to the Migraine–Stroke Connection. International Journal of Molecular Sciences, 26(14), 6634.
Kumar, R. I., Jain, K., Rai, K. R., Gururajan, H., & Sarkar, K. (2025). Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers. Immunologic Research, 73(1), 121.
Ledowsky, C. J., Schloss, J., & Steel, A. (2025). Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study. Journal of the Australasian College of Nutritional and Environmental Medicine, 44(1), 40–55.
Li, B., He, D., Zhu, H., Li, Y., Ye, W., Guo, D., Yu, M., Wu, Y., Cai, J., & Ji, L. (2025). Factors influencing the birth weight of ART-conceived offspring. Journal of Assisted Reproduction and Genetics, 1–22.
Li, J., Duan, H., Ramaswamy, H., & Wang, C. (2025). A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate. International Journal of Molecular Sciences, 26(16), 7703.
Li, J. S., Riggins, K., Yang, L., Chen, C., Castro, P., Alfarkh, W., Zarrin-Khameh, N., Scheurer, M. E., Creighton, C. J., & Musher, B. (2025). DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations. Clinical Epigenetics, 17(1), 11.
Li, T., Li, Y., Yin, L., Li, W., Li, Z., Ma, F., Chen, Y., Yan, J., & Huang, G. (2025). Folic acid fortification and late‐onset colorectal cancer risk: A systematic assessment of the worldwide evidence. International Journal of Cancer.
Liang, J., Zhao, Y., Cheng, Y., Hu, Z., Yuan, Y., Xiao, J., Farag, M. A., Cai, X., Cao, H., & Yue, T. (2025). Polyphenols, epigenetics, and methionine metabolism: unlocking therapeutic potential. Critical Reviews in Food Science and Nutrition, 1–16.
Liu, L., Ni, S., Zhang, L., Chen, Y., Xie, M., & Huang, X. (2025). Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review. BMC Nephrology, 26(1), 253.
Liu, Y., & Wang, X. (2025). Post-translational Modifications of the Nucleoid Protein H-NS: Sites, Mechanisms, and Regulatory Cues. FEMS Microbiology Reviews, fuaf045.
Ly, A., Hoyt, L., Crowell, J., & Kim, Y.-I. (2012). Folate and DNA methylation. Antioxidants & Redox Signaling, 17(2), 302–326.
Madiwale, S., Joshi, N., Randhir, K., Pisal, H., Kadam, V., Krishnaveni, G., Wagh, G., Gupte, S., Fall, C., & Joshi, S. (2025). Longitudinal assessment of maternal micronutrients (folate and vitamin B12) and homocysteine levels in women who develop gestational diabetes mellitus. European Journal of Clinical Nutrition, 1–9.
Maher, N., Maiellaro, F., Ghanej, J., Rasi, S., Moia, R., & Gaidano, G. (2025). Unraveling the Epigenetic Landscape of Mature B Cell Neoplasia: Mechanisms, Biomarkers, and Therapeutic Opportunities. International Journal of Molecular Sciences, 26(17), 8132.
Mai, H. A., Thomas, C. M., Nge, G. G., & Elefant, F. (2025). Modulating Cognition-Linked Histone Acetyltransferases (HATs) as a Therapeutic Strategy for Neurodegenerative Diseases: Recent Advances and Future Trends. Cells, 14(12), 873.
Maj, M. C., & Upadhya, S. (2025). Perspective Chapter: Multifactorial Disorders–Understanding the Risks of Inheritance.
Mäki-Nevala, S., Kauppinen, A., Olkinuora, A., Laiho, A., Törönen, P., Renkonen-Sinisalo, L., Lepistö, A., Seppälä, T. T., Mecklin, J.-P., & Peltomäki, P. (2025). Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis. Clinical Epigenetics, 17(1), 137.
Marei, H. E. (2025). Epigenetic regulators in cancer therapy and progression. NPJ Precision Oncology, 9(1), 1–18.
Megala, G., & Kavitha, M. (2025). Folate from probiotic bacteria and its therapeutic applications. Archives of Microbiology, 207(6), 124.
Mellor, C., Larson, E. A., & Wang, M. (2025). Mechanisms of genome instability from cellular folate stress. Journal of Cell Biology, 224(9), e202502205.
Ménézo, Y., Elder, K., Clement, P., Dattilo, M., & Patrizio, P. (2025). Fortification with folic acid and early human embryo development: lessons from assisted reproduction. Journal of Assisted Reproduction and Genetics, 1–7.
Michael, I. (2025a). Chromatin remodeling and histone modification influenced by GAS5-miRNA interaction.
Michael, I. (2025b). GAS5 as an epigenetic scaffold in the recruitment of chromatin modifiers.
Moghadamnia, A., Karim, B., Ebrahimi, P., Rafati Rahimzadeh, M., Nazari-Taloki, Z., & Kazemi, S. (2025). 5-Fluorouracil (5-FU)-Induced Organ Toxicities: Mechanisms, Management, and Prevention Strategies. Toxicology Mechanisms and Methods, just-accepted, 1–41.
Montano, C., & Timp, W. (2025). Evolution of genome-wide methylation profiling technologies. Genome Research, 35(4), 572–582.
Naderi, N., Tavalaee, M., & Nasr-Esfahani, M. H. (2025). The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation. Human Reproduction Update, 31(2), 81–101.
Nie, L., Liu, X., Li, X., Ren, Z., Cheng, X., Wu, Y., Li, Z., & Liu, J. (2025). Beyond Folate: The Emerging Role of Maternal Vitamin B12 in Neural Tube Development. Nutrients, 17(12), 2040.
Nishikawa, S., Yu, W.-C., Chiang, Y.-R., Wu, T.-Y., Tang, I., Khusnutdinova, A., Yakunin, A., Fujishima, K., & Wang, P.-H. (2025). Methanol-driven, one-pot chemoenzymatic S-adenosylmethionine regeneration for ambient cobalamin-dependent methyltransferase reactions. ACS Catalysis, 15(15), 13689–13703.
Pacołta, A., Nalepka, M., Pograniczny, M., Mielżyńska, A., Pochopień, J., Nowicka, A., Jankowska, M., Baran, K., Jańczyk, N., & Presak, M. (2025). Analysis of selected nutritional and environmental factors leading to the development of neural tube defects. Quality in Sport, 41, 60332.
Paggi, J. M., & Zhang, B. (2025). Euchromatin forms condensed domains with short active regions on the surface. BioRxiv, 2008–2025.
Pannia, E. (2021). Effect of Folate Dose and Form During Pregnancy on Early-and Later-Life Phenotype of the Wistar Rat Mother and Her Female Offspring. University of Toronto (Canada).
Paris, G., Katsuya-Gaviria, K., & Luisi, B. F. (2025). Machinery, mechanism, and information in post-transcription control of gene expression, from the perspective of unstable RNA. Quarterly Reviews of Biophysics, 58, e10.
Parkes, J. P. (2025). The health economic benefits of improved diagnosis of vitamin B12 deficiency in primary care patients, associated with a new diagnostic testing algorithm. Manchester Metropolitan University.
Pidsley, R., Dempster, E., Troakes, C., Al-Sarraj, S., & Mill, J. (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15. 5 is associated with cerebellum weight. Epigenetics, 7(2), 155–163.
Pignataro, G., Triunfo, C., Piccioni, A., Racco, S., Fuorlo, M., Forte, E., Franceschi, F., & Candelli, M. (2025). The Epigenetics of Sepsis: How Gene Modulation Shapes Outcomes. Biomedicines, 13(8), 1936.
Plunk, E. C., & Richards, S. M. (2020). Epigenetic modifications due to environment, ageing, nutrition, and endocrine disrupting chemicals and their effects on the endocrine system. International Journal of Endocrinology, 2020(1), 9251980.
Popa, L. C., Abu-Awwad, A., Farcas, S. S., Abu-Awwad, S.-A., & Andreescu, N. I. (2025). Interaction Between CYP1A2-Related Caffeine Metabolism and Vitamin B12/Folate Status in Patients with Metabolic Syndrome: A Novel Biomarker Axis. Metabolites, 15(7), 450.
Powell, B. H., Witwer, K. W., & Meffert, M. K. (2025). Cellular miRNAs and viruses: trends in miRNA sequestering and target de-repression. Journal of Virology, e00914-25.
Prabsattru, P., Nakbua, T., Sengphairogh, S., Kitkumthorn, N., & Meevassana, J. (2025). Methylation of LINE-1 and Alu repetitive sequence in keloid. Scientific Reports, 15(1), 31994.
Puspitasari, M. K., Irianti, S., Pramatirta, A. Y., Wirawan, W., Islamy, N., Maelissa, M. M., & Lumentut, A. M. (2025). Folate Metabolism and Its Implications in Pregnancy. Journal La Medihealtico, 6(2), 285–298.
Ragusa, M. A., Gentile, C., Nicosia, A., Costa, S., Volpes, S., Greco, L., Naselli, F., & Caradonna, F. (2025). Epigenetic Remodeling of Regulatory Regions by Indicaxanthin Suggests a Shift in Cell Identity Programs in Colorectal Cancer Cells. International Journal of Molecular Sciences, 26(13), 6072.
Rehman, S. U., Abdullah, M., Khan, Z. K., & Shurovi, M. (2025). The role of DNA methylation and histone modifications in the pathogenesis of hematological malignancies and solid cancers: mechanisms, clinical implications, and therapeutic potential. Asian Journal of Medical and Biological Research, 11(2), 23–36.
Reynolds, C. M., & Vickers, M. H. (2019). Early Life Developmental Programming of the GH/IGF Axis and Long-Term Health. In Early Life Origins of Ageing and Longevity (pp. 67–86). Springer.
Reynolds, E. H. (2025). Folate, vitamin B12, one carbon metabolism and the nervous system. Journal of the Neurological Sciences, 123627.
Rodenburg, W. S., Strom, A. R., & Eeftens, J. M. (2025). Heterogeneity as a feature: unraveling chromatin’s role in nuclear mechanics. Nucleus, 16(1), 2545037.
Rondanelli, M., Borromeo, S., Cavioni, A., Gasparri, C., Gattone, I., Genovese, E., Lazzarotti, A., Minonne, L., Moroni, A., & Patelli, Z. (2025). Therapeutic strategies to modulate gut microbial health: approaches for chronic metabolic disorder management. Metabolites, 15(2), 127.
Roy, S. (2025). Regulation of Gene Expression by Chemical Modifications. In Gene Expression and its Regulation: An Evolutionary Perspective (pp. 181–209). Springer.
Roy, S., & Ghosh, M. K. (2025). Ubiquitin proteasome system (UPS): a crucial determinant of the epigenetic landscape in cancer. Epigenomics, 17(9), 625–644.
Sadia, K., Castagna, A., Udali, S., Ambrosani, F., Pattini, P., Beri, R., Argentino, G., Masutti, M., Moruzzi, S., & Friso, S. (2025). Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma. Cells, 14(17), 1337.
Saha, D., Kanjilal, P., Kaur, M., Menon, S. V, Ashraf, A., Kumar, M. R., Alqahtani, T., Atteri, S., Uti, D. E., & Dhara, B. (2025). Transforming Cancer Diagnostics: The Emergence of Liquid Biopsy and Epigenetic Markers. MedComm, 6(9), e70388.
Salavoura, A. (2025). Metals and Disease. In Chemical Environmental Pollutants and their Effect on Health (pp. 55–214). Springer.
Sangha, V. (2025). Novel Approaches for Effective Folate Delivery in Cerebral Folate Deficiency Disorders. University of Toronto (Canada).
Shadfar, A. (2025). Characterization of metabolic safeguarding factors in the context of direct cellular reprogramming. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky.
Shokrollahi, B., Park, M., Jang, G.-S., Jin, S., Moon, S.-J., Um, K.-H., Jang, S.-S., & Baek, Y.-C. (2025). Maternal Overnutrition in Beef Cattle: Effects on Fetal Programming, Metabolic Health, and Postnatal Outcomes. Biology, 14(6), 645.
Shu, Q., Liu, Y., & Ai, H. (2025). The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease. Cells, 14(4), 307.
Singh, M., Priya, K., Nagar, A., & Nalavade, R. (2025). Emerging landscape of lncRNA-miRNA interactions as architects of gene expression patterns. Molecular Biology Reports, 52(1), 1–15.
Smith, Z. D., Hetzel, S., & Meissner, A. (2025). DNA methylation in mammalian development and disease. Nature Reviews Genetics, 26(1), 7–30.
Song, J., Yang, P., Chen, C., Ding, W., Tillement, O., Bai, H., & Zhang, S. (2025). Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance. Signal Transduction and Targeted Therapy, 10(1), 219.
Souza, A. P. de, Marinho, V., & Marques, M. R. (2025). The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance. Epigenomes, 9(3), 23.
Sun, Y.-H., Zhang, J.-X., Jin, H.-S., & Huang, J. (2025). Crosstalk Between Metabolic Reprogramming and Epigenetic Modifications in Colorectal Cancer: Mechanisms and Clinical Applications. Current Issues in Molecular Biology, 47(9), 751.
Tang, J., Zhuang, Y., Zhang, Y., Hu, H., Wang, H., Xu, H., Li, Y., & Tu, C. (2025). Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications. Journal of Hematology & Oncology, 18(1), 77.
Theis, B. F., Park, J. S., Kim, J. S. A., Zeydabadinejad, S., Vijay-Kumar, M., Yeoh, B. S., & Saha, P. (2025). Gut feelings: How microbes, diet, and host immunity shape disease. Biomedicines, 13(6), 1357.
Tian, W., Ju, J., Guan, B., Wang, T., Zhang, J., Song, L., & Xu, H. (2025). Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside. Annals of Medicine, 57(1), 2457527.
Triantaphyllopoulos, K. A., Ragia, N. D., Panagiotopoulou, M.-C. E., & Sourlingas, T. G. (2025). Integrating Inflammatory and Epigenetic Signatures in IBD-Associated Colorectal Carcinogenesis: Models, Mechanisms, and Clinical Implications.
Vaidya, H., Jelinek, J., & Issa, J.-P. J. (2025). DNA Methylation, Aging, and Cancer. Epigenomes, 9(2), 18.
Van Dijck, E., Van Laere, S., Logie, E., Timmermans, S., Fransen, E., Ibrahim, J., Kendall, T. J., Fallowfield, J. A., Mateiu, L. M., & Libert, C. (2025). Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration. Clinical Epigenetics, 17(1), 138.
Verma, A., & Lindroth, A. M. (2025). The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer. Experimental & Molecular Medicine, 1–12.
Vickram, S., Infant, S. S., Sivasubramanian, M., Anbalagan, S., Marimuthu, M. M. C., & Chopra, H. (2025). Epigenetic modulation in cancer drug discovery: promising targets and clinical applications. Pharmacological Reports, 1–20.
Vlasac, I., Christensen, B. C., & Salas, L. A. (2025). Normal gastric tissue Helicobacter pylori infection is associated with tissue cell composition, and cell type–specific epigenetic age acceleration, mitotic tick rate, and repetitive element methylation alterations. Epigenetics Reports, 3(1), 2554836.
Vujić, A. (n.d.). Targeting DNA methylation and histone modifications using CRISPR/dCas9 tools in the regulation of glycosyltransferases gene expression of HepG2 cells.
Wallace, T. C., Cowan-Pyle, A. E., Klatt, K. C., & Bailey, R. L. (2025). Relationship of Choline Intake with Biomarkers of Liver Health by Genotype–A Cross-Sectional Analysis. The Journal of Nutrition, 155(6), 1970–1977.
Wang, Y., Huang, Z., Jin, C., Shen, X., He, X., & Yang, C. (2025). Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis. PLoS One, 20(7), e0305517.
Williams, S., Clark, S. J., Pidsley, R., & Stirzaker, C. (2025). DNA methylation biomarkers for the diagnosis and treatment management of breast cancer: where are we now? Epigenomics, 1–16.
Xiao, J., Qin, X., Chen, W., Que, X., Ma, Y., Huang, W., Ou, H., Bao, Y., Qu, L., & Shan, S. (2025). Immunoinflammation and post-translational modifications in the aging process. Journal of Translational Medicine, 23(1), 910.
Xing, Z., & Tu, B. P. (2025). Mechanisms and rationales of SAM homeostasis. Trends in Biochemical Sciences, 50(3), 242–254.
Yan, C., He, B., Wang, C., Li, W., Tao, S., Chen, J., Wang, Y., Yang, L., Wu, Y., & Wu, Z. (2025). Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway. Critical Reviews in Food Science and Nutrition, 1–24.
Yan, X., & Liu, C. (2025). The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting. Cell Death Discovery, 11(1), 390.
Yildiz, M. (2025). Epigenetic Mechanisms in Heart Diseases. Reviews in Cardiovascular Medicine, 26(7), 38696.
Youngson, N. A., Tourna, A., Chalmers, T., Prates, K. V, Argemi, J., Bataller, R., Haghighi, K. S., Wu, L. E., Chokshi, S., & Starkel, P. (2025). Multi-Cohort Exploration of Repetitive Element Transcription and DNA Methylation in Human Steatotic Liver Disease. International Journal of Molecular Sciences, 26(12), 5494.
Yun, P., Kulaixijiang, K., Pan, J., Yang, L., Wang, N., Xu, Z., Zhang, Y., Cai, H., Zhao, Z., & Zhu, M. (2025). Early colorectal cancer diagnosis: A novel methylated stool DNA model enhanced the diagnostic efficiency. United European Gastroenterology Journal, 13(3), 402–415.
Yusoff, N. A., Abd Hamid, Z., Taib, I. S., Abdul Razak, S. R., & Budin, S. B. (2025). Exploring epigenetic complexity in regulation of hematopoietic stem cells niche: a mechanistic journey from normal to malignant hematopoiesis.
Zainuddin, M.-S., Ghanesh, K., Ganesan, N., Kumari, M., Radhakrishnan, A. K., & Bhuvanendran, S. (2025). Epigenetic modulations and nutrient interactions in Alzheimer’s disease: unveiling potential therapeutic pathways. Nutritional Neuroscience, 1–23.
Zhang, X., Liu, D., Chen, X., Li, T., & Wu, G. (2025). Chromatin and epigenetic regulation in malignant tumors: A comprehensive review. Annals of the New York Academy of Sciences.
Zhou, R., Zhu, Z., Wang, Z., Dong, M., Huang, L., Wang, S., Zhang, X., & Liu, F. (2025). Association between MTHFR polymorphisms and vitamin D status in infertile women: a mediation analysis. Frontiers in Nutrition, 12, 1644302.
Zhou, W., & Reizel, Y. (2025). On correlative and causal links of replicative epimutations. Trends in Genetics, 41(1), 60–75.
Zwart, N. R. K., Kok, D. E., Ariyaratne, S. N. H., & McKay, J. A. (2025). Folate‐Associated DNA Methylation and Chemotherapy‐Induced Toxicities in Patients With Colorectal Cancer. Molecular Nutrition & Food Research, e70127.
Ahmad, F., Uzair, S. A., Lakshmanan, A. P., Alabduljabbar, S., Ahmed, S. H., Kabeer, B. S. A., Marr, A. K., Kino, T., Brummaier, T., & McGready, R. (2025). Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats. Molecular Nutrition & Food Research, e70058.
Alemu, R., Sharew, N. T., Arsano, Y. Y., Ahmed, M., Tekola-Ayele, F., Mersha, T. B., & Amare, A. T. (2025). Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues. Human Genomics, 19(1), 8.
Ali, S., & Tang, Y. (2025). Noncoding RNA-mediated regulation of DNA methylation: insights into plant epigenetic mechanisms. Journal of Plant Growth Regulation, 44(2), 373–388.
Ambrosio, S., Noviello, A., Di Fusco, G., Gorini, F., Piscone, A., Amente, S., & Majello, B. (2025). Interplay and dynamics of chromatin architecture and DNA damage response: An overview. Cancers, 17(6), 949.
An, Y., Wang, Q., Gao, K., Zhang, C., Ouyang, Y., Li, R., Ma, Z., Wu, T., Zhou, L., & Xie, Z. (2025). Epigenetic Regulation of Aging and its Rejuvenation. MedComm, 6(9), e70369.
Aquilino, M., Ditzer, N., Namba, T., & Albert, M. (2025). Epigenetic and metabolic regulation of developmental timing in neocortex evolution. Trends in Neurosciences.
Arachchillage, D. P. W., & Udomsinprasert, W. (2025). Long interspersed nuclear element 1 methylation in non-small cell lung cancer: implications for diagnosis, prognosis, and therapeutic targeting. Cell Communication and Signaling, 23(1), 350.
Araszkiewicz, A. F., Jańczak, K., Wójcik, P., Białecki, B., Kubiak, S., Szczechowski, M., & Januszkiewicz-Lewandowska, D. (2025). MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A Review. Genes, 16(4), 441.
Aswathy, V. J., & VR, S. (2025). AYURVEDA AND EPIGENETICS: FOUNDATIONS FOR PREVENTIVE AND PRECISION HEALTHCARE. Kottakkal Journal of Ayurvedic Medicine And Research, 1(3), 20–27.
Avram, O.-E., Bratu, E.-A., Curis, C., Moroianu, L.-A., & Drima, E. (2025). Modifiable Nutritional Biomarkers in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis of Vitamin D, B12, and Homocysteine Exposure Spanning Prenatal Development Through Late Adolescence. International Journal of Molecular Sciences, 26(9), 4410.
Ayoub, G. (2025). Vitamins, Vascular Health and Disease. Nutrients, 17(18), 2955.
Bakkar, M., Khalil, S., Bhayekar, K., Kushwaha, N. D., Samarbakhsh, A., Dorandish, S., Edwards, H., Dou, Q. P., Ge, Y., & Gavande, N. S. (2025). Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. Biomolecules, 15(2), 240.
Bakrim, S., El Omari, N., El Yaagoubi, O. M., Khalid, A., Abdalla, A. N., Hamza, S. M. A., Ibrahim, S. E., Atifi, F., Zaid, Y., & Bouyahya, A. (2025). Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights. Cell Biology and Toxicology, 41(1), 116.
Bartak, B. K., Nagy, Z. B., Szakallas, N., Kalmar, A., Farkas, E., Banyai, F., Pipek, O., Csabai, I., Sydo, N., & Csulak, E. (2025). Examination of Genetic and Epigenetic Characteristics of Patients with Hyperhomocysteinemia Following High-Dose Folic Acid Consumption. Nutrients, 17(13), 2133.
Bhasker, A., & Veleri, S. (2025). Fundamental origins of neural tube defects with a basis in genetics and nutrition. Experimental Brain Research, 243(4), 79.
Bidoli, C. (2025). In silico identification of predictive markers for precision medicine in pediatric diseases.
Blomgren, L. K. M. (2025). Defining the Structure-Function Relationship behind Allosteric Regulation of 5, 10-Methylenetetrahydrofolate Reductase. University of Zurich.
Brethouwer, T., de Mendoza, A., & Bogdanovic, O. (2025). Non-CG DNA methylation in animal genomes. Nature Genetics, 1–13.
Brown, L. T. L., Pereira, D., & Winn, L. M. (2025). A Narrative Review on the Effect of Valproic Acid on the Placenta. Birth Defects Research, 117(4), e2471.
Castillo, L. F., Pelletier, C. M., Heyden, K. E., & Field, M. S. (2025). New Insights into Folate–Vitamin B12 Interactions. Annual Review of Nutrition, 45.
Cerreto, G. M., Pozzi, G., Cortellazzi, S., Pasini, L. M., Di Martino, O., Mirandola, P., Carubbi, C., Vitale, M., & Masselli, E. (2025). Folate metabolism in myelofibrosis: a missing key? Annals of Hematology, 104(1), 35–46.
Chen, L., van der Veer, B. K., Chen, Q., Champeris Tsaniras, S., Brangers, W., Kwak, H. H. M., Khoueiry, R., Lei, Y., Cabrera, R., & Gross, S. S. (2025). The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development. EMBO Reports, 26(1), 175–199.
Clement, A., Viot, G., Elder, K., Clement, P., & Menezo, Y. J. R. (2025). Can some metabolic one-carbon cycle linked diseases be prevented? The impact of treating hypo-fertile couples carrying MTHFR SNPs with folic acid and 5-MTHF on outcomes in the offspring: a case retrospective series. Journal of Assisted Reproduction and Genetics, 42(2), 533–539.
Cohen, N. J., Lesseur, C., Cardenas, A., Ward-Caviness, C. K., Spring, A. C., Rager, J. E., Fry, R. C., & Eaves, L. A. (2025). Placental DNA methylation key topics: sex-and cell-type specificity, mediation, multi-omics, and biomarker discovery. Epigenomics, 17(13), 905–921.
Costa, S., La Rocca, G., & Cavalieri, V. (2025). Epigenetic regulation of chromatin functions by MicroRNAs and long noncoding RNAs and implications in human diseases. Biomedicines, 13(3), 725.
Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012). Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Advances in Nutrition (Bethesda, Md.), 3(1), 21–38. https://doi.org/10.3945/an.111.000992
Davie, J. R., Sattarifard, H., Sudhakar, S. R. N., Roberts, C.-T., Beacon, T. H., Muker, I., Shahib, A. K., & Rastegar, M. (2025). Basic Epigenetic Mechanisms. Neuroepigenetics Mechanisms in Health and Disease, 1–49.
Du, L., Gao, R., & Chen, Z. (2025). 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism. International Journal of Molecular Sciences, 26(6), 2560.
Dutta, S., Dutta, S., Somanath, P. R., Narayanan, S. P., Wang, X., & Zhang, D. (2025). Circulating nucleosomes and histones in the development of lung injury and sepsis. Current Issues in Molecular Biology, 47(2), 133.
Ediriweera, M. K., & Sandamalika, W. M. G. (2025). The epigenetic impact of fatty acids as DNA methylation modulators. Drug Discovery Today, 30(2), 104277.
Emre, S., Algin, A., & Toros, T. (2025). The Relationship Between Exercise and Sport and Epigenetics. Cuestiones de Fisioterapia, 54(3), 4859–4871.
Engin, A. B., & Engin, A. (2025). Nanoparticle Mediated Epigenetic and Immunological Modulation. In Nanosafety: A Comprehensive Approach to Assess Nanomaterial Exposure on the Environment and Health (pp. 87–114). Springer.
Fang, Z., Zhou, Y., Chen, K., Wang, J., Liu, X., & Jia, P. (2025). Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism. Frontiers in Neuroscience, 19, 1587818.
Fatima, N., Yaqoob, S., Rana, L., Imtiaz, A., Iqbal, M. J., Bashir, Z., Shaukat, A., Naveed, H., Sultan, W., & Afzal, M. (2025). Micro-nutrient sufficiency in mothers and babies: management of deficiencies while avoiding overload during pregnancy. Frontiers in Nutrition, 12, 1476672.
Fernández-Ramos, D., Lopitz-Otsoa, F., Lu, S. C., & Mato, J. M. (2025). S-adenosylmethionine: a multifaceted regulator in cancer pathogenesis and therapy. Cancers, 17(3), 535.
Fernandez, A. F., Assenov, Y., Martin-Subero, J. I., Balint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M., Tan, A.-C., Galm, O., Ferrer, I., Sanchez-Cespedes, M., Villanueva, A., Carmona, J., Sanchez-Mut, J. V, Berdasco, M., Moreno, V., Capella, G., Monk, D., … Esteller, M. (2012). A DNA methylation fingerprint of 1628 human samples. Genome Research, 22(2), 407–419. https://doi.org/10.1101/gr.119867.110
Flori, L., Veneziano, S., Martelli, A., Piragine, E., & Calderone, V. (2025). Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid. International Journal of Molecular Sciences, 26(13), 6430.
Frost, Z., Bakhit, S., Amaefuna, C. N., Powers, R. V, & Ramana, K. V. (2025). Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression. International Journal of Molecular Sciences, 26(5), 1967.
Gogineni, G. R., Kamireddy, S., Ramani, N. D., Parveen, S., & Kumar, A. R. (2025). A Comprehensive Review on Micro RNA In Medical Domain. International Symposium on Sustainable Drug Design and Nanoparticle Development: Quantum and Computational Perspectives (SDDNDQCP 2025), 378–392.
González-Ludlow, I., Rodríguez-Cano, A. M., Mendoza-Ortega, J. A., Rodríguez-Hernández, C., Suárez-Rico, B. V, Estrada-Gutierrez, G., Tolentino-Dolores, M., Parra-Hernández, S. B., Sánchez-Martínez, M., & Acevedo-Gallegos, S. (2025). Maternal folate and vitamin B 12 concentrations during pregnancy influence neonatal nutritional status and adiposity: results from the OBESO cohort. Nutrients, 17(3), 372.
Günçer, B., Özkök, F., Aldoğan, E. H., Oyacı, Y., Nazlıgül, E., Edis, B. Ö., Akbarzadeh, S., Onul, N., Akdemir, A., & Atalay, V. E. (2025). Synthesis, in-vitro, in-silico, and global DNA methylation studies of curcumin-benzoquinone analog in triple-negative breast cancer (TNBC) cells. Toxicology Research, 14(4), tfaf128.
Gunnala, S., Buhlman, L. M., & Jadavji, N. M. (2025). How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity. Nutrients, 17(7), 1286.
Hamdani, S., Hamijoyo, L., Amalia, R., & Barliana, M. I. (2025). Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review. Frontiers in Genetics, 16, 1594648.
IKE, P. C., ENYINNAYA, A. C., UJAM, C. G., AYINDE, M. K., GOLDEN, F. I., OLATOKUN, T. P., & NASIR, K. (2025). INVESTIGATING THE RELATIONSHIP BETWEEN NUTRITION AND DNA MARKERS ASSOCIATED WITH HEART HEALTH IN MIDDLE-AGED ADULTS WITH TYPE 2 DIABETES. International Journal of Convergent and Informatics Science Research.
Imran, K., Iqbal, M. J., Ahmed, M. M., Khalid, A., Cortés, H., Reyes-Hernández, O. D., Figueroa-González, G., Leyva-Gómez, G., Falzone, L., & Libra, M. (2025). Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies. Medical Oncology, 42(8), 359.
Jang, S., Choi, N., Park, J. H., & Yoo, K. H. (2025). Contribution of histone deacetylases (HDACs) to the regulation of histone and non-histone proteins: implications for fibrotic diseases. BMB Reports, 58(8), 313.
Jiao, P., Lu, H., Hao, L., Degen, A. A., Cheng, J., Yin, Z., Mao, S., & Xue, Y. (2025). Nutrigenetic and epigenetic mechanisms of maternal nutrition–induced glucolipid metabolism changes in the offspring. Nutrition Reviews, 83(4), 728–748.
Kapała, A., Różycka, K., & Dąbrowska-Bender, M. (2025). A clinical retrospective study—the investigation of folic acid concentration in caucasian cancer patients. Nowotwory. Journal of Oncology, 75(1), 1–9.
Kaya, C., & Adamakis, I.-D. S. (2025). Redox-Epigenetic Crosstalk in Plant Stress Responses: The Roles of Reactive Oxygen and Nitrogen Species in Modulating Chromatin Dynamics. International Journal of Molecular Sciences, 26(15), 7167.
Khatami, F., Bahri, R. A., Sharifkazemi, H., Sajadi, S. M., Shamshirgaran, A., & Le Calvez-Kelm, F. (2025). Molecular biology and epigenetic modifications definition. In Genetics and Epigenetics of Genitourinary Diseases (pp. 37–61). Elsevier.
Kim, D.-H. (2025). Epigenetic regulators and their involvement in the stress response of Arabidopsis plants: Emphasis on histone modifications and chromatin remodeling. Journal of Plant Biology, 1–22.
Krekora, J., Fila, M., Mitus-Kenig, M., Pawlowska, E., Ciupinska, J., & Blasiak, J. (2025). Sirtuins Contribute to the Migraine–Stroke Connection. International Journal of Molecular Sciences, 26(14), 6634.
Kumar, R. I., Jain, K., Rai, K. R., Gururajan, H., & Sarkar, K. (2025). Targeting epigenetic modifications as an emerging immunotherapeutic strategy for cancers. Immunologic Research, 73(1), 121.
Ledowsky, C. J., Schloss, J., & Steel, A. (2025). Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study. Journal of the Australasian College of Nutritional and Environmental Medicine, 44(1), 40–55.
Li, B., He, D., Zhu, H., Li, Y., Ye, W., Guo, D., Yu, M., Wu, Y., Cai, J., & Ji, L. (2025). Factors influencing the birth weight of ART-conceived offspring. Journal of Assisted Reproduction and Genetics, 1–22.
Li, J., Duan, H., Ramaswamy, H., & Wang, C. (2025). A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate. International Journal of Molecular Sciences, 26(16), 7703.
Li, J. S., Riggins, K., Yang, L., Chen, C., Castro, P., Alfarkh, W., Zarrin-Khameh, N., Scheurer, M. E., Creighton, C. J., & Musher, B. (2025). DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations. Clinical Epigenetics, 17(1), 11.
Li, T., Li, Y., Yin, L., Li, W., Li, Z., Ma, F., Chen, Y., Yan, J., & Huang, G. (2025). Folic acid fortification and late‐onset colorectal cancer risk: A systematic assessment of the worldwide evidence. International Journal of Cancer.
Liang, J., Zhao, Y., Cheng, Y., Hu, Z., Yuan, Y., Xiao, J., Farag, M. A., Cai, X., Cao, H., & Yue, T. (2025). Polyphenols, epigenetics, and methionine metabolism: unlocking therapeutic potential. Critical Reviews in Food Science and Nutrition, 1–16.
Liu, L., Ni, S., Zhang, L., Chen, Y., Xie, M., & Huang, X. (2025). Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review. BMC Nephrology, 26(1), 253.
Liu, Y., & Wang, X. (2025). Post-translational Modifications of the Nucleoid Protein H-NS: Sites, Mechanisms, and Regulatory Cues. FEMS Microbiology Reviews, fuaf045.
Ly, A., Hoyt, L., Crowell, J., & Kim, Y.-I. (2012). Folate and DNA methylation. Antioxidants & Redox Signaling, 17(2), 302–326.
Madiwale, S., Joshi, N., Randhir, K., Pisal, H., Kadam, V., Krishnaveni, G., Wagh, G., Gupte, S., Fall, C., & Joshi, S. (2025). Longitudinal assessment of maternal micronutrients (folate and vitamin B12) and homocysteine levels in women who develop gestational diabetes mellitus. European Journal of Clinical Nutrition, 1–9.
Maher, N., Maiellaro, F., Ghanej, J., Rasi, S., Moia, R., & Gaidano, G. (2025). Unraveling the Epigenetic Landscape of Mature B Cell Neoplasia: Mechanisms, Biomarkers, and Therapeutic Opportunities. International Journal of Molecular Sciences, 26(17), 8132.
Mai, H. A., Thomas, C. M., Nge, G. G., & Elefant, F. (2025). Modulating Cognition-Linked Histone Acetyltransferases (HATs) as a Therapeutic Strategy for Neurodegenerative Diseases: Recent Advances and Future Trends. Cells, 14(12), 873.
Maj, M. C., & Upadhya, S. (2025). Perspective Chapter: Multifactorial Disorders–Understanding the Risks of Inheritance.
Mäki-Nevala, S., Kauppinen, A., Olkinuora, A., Laiho, A., Törönen, P., Renkonen-Sinisalo, L., Lepistö, A., Seppälä, T. T., Mecklin, J.-P., & Peltomäki, P. (2025). Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis. Clinical Epigenetics, 17(1), 137.
Marei, H. E. (2025). Epigenetic regulators in cancer therapy and progression. NPJ Precision Oncology, 9(1), 1–18.
Megala, G., & Kavitha, M. (2025). Folate from probiotic bacteria and its therapeutic applications. Archives of Microbiology, 207(6), 124.
Mellor, C., Larson, E. A., & Wang, M. (2025). Mechanisms of genome instability from cellular folate stress. Journal of Cell Biology, 224(9), e202502205.
Ménézo, Y., Elder, K., Clement, P., Dattilo, M., & Patrizio, P. (2025). Fortification with folic acid and early human embryo development: lessons from assisted reproduction. Journal of Assisted Reproduction and Genetics, 1–7.
Michael, I. (2025a). Chromatin remodeling and histone modification influenced by GAS5-miRNA interaction.
Michael, I. (2025b). GAS5 as an epigenetic scaffold in the recruitment of chromatin modifiers.
Moghadamnia, A., Karim, B., Ebrahimi, P., Rafati Rahimzadeh, M., Nazari-Taloki, Z., & Kazemi, S. (2025). 5-Fluorouracil (5-FU)-Induced Organ Toxicities: Mechanisms, Management, and Prevention Strategies. Toxicology Mechanisms and Methods, just-accepted, 1–41.
Montano, C., & Timp, W. (2025). Evolution of genome-wide methylation profiling technologies. Genome Research, 35(4), 572–582.
Naderi, N., Tavalaee, M., & Nasr-Esfahani, M. H. (2025). The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation. Human Reproduction Update, 31(2), 81–101.
Nie, L., Liu, X., Li, X., Ren, Z., Cheng, X., Wu, Y., Li, Z., & Liu, J. (2025). Beyond Folate: The Emerging Role of Maternal Vitamin B12 in Neural Tube Development. Nutrients, 17(12), 2040.
Nishikawa, S., Yu, W.-C., Chiang, Y.-R., Wu, T.-Y., Tang, I., Khusnutdinova, A., Yakunin, A., Fujishima, K., & Wang, P.-H. (2025). Methanol-driven, one-pot chemoenzymatic S-adenosylmethionine regeneration for ambient cobalamin-dependent methyltransferase reactions. ACS Catalysis, 15(15), 13689–13703.
Pacołta, A., Nalepka, M., Pograniczny, M., Mielżyńska, A., Pochopień, J., Nowicka, A., Jankowska, M., Baran, K., Jańczyk, N., & Presak, M. (2025). Analysis of selected nutritional and environmental factors leading to the development of neural tube defects. Quality in Sport, 41, 60332.
Paggi, J. M., & Zhang, B. (2025). Euchromatin forms condensed domains with short active regions on the surface. BioRxiv, 2008–2025.
Pannia, E. (2021). Effect of Folate Dose and Form During Pregnancy on Early-and Later-Life Phenotype of the Wistar Rat Mother and Her Female Offspring. University of Toronto (Canada).
Paris, G., Katsuya-Gaviria, K., & Luisi, B. F. (2025). Machinery, mechanism, and information in post-transcription control of gene expression, from the perspective of unstable RNA. Quarterly Reviews of Biophysics, 58, e10.
Parkes, J. P. (2025). The health economic benefits of improved diagnosis of vitamin B12 deficiency in primary care patients, associated with a new diagnostic testing algorithm. Manchester Metropolitan University.
Pidsley, R., Dempster, E., Troakes, C., Al-Sarraj, S., & Mill, J. (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15. 5 is associated with cerebellum weight. Epigenetics, 7(2), 155–163.
Pignataro, G., Triunfo, C., Piccioni, A., Racco, S., Fuorlo, M., Forte, E., Franceschi, F., & Candelli, M. (2025). The Epigenetics of Sepsis: How Gene Modulation Shapes Outcomes. Biomedicines, 13(8), 1936.
Plunk, E. C., & Richards, S. M. (2020). Epigenetic modifications due to environment, ageing, nutrition, and endocrine disrupting chemicals and their effects on the endocrine system. International Journal of Endocrinology, 2020(1), 9251980.
Popa, L. C., Abu-Awwad, A., Farcas, S. S., Abu-Awwad, S.-A., & Andreescu, N. I. (2025). Interaction Between CYP1A2-Related Caffeine Metabolism and Vitamin B12/Folate Status in Patients with Metabolic Syndrome: A Novel Biomarker Axis. Metabolites, 15(7), 450.
Powell, B. H., Witwer, K. W., & Meffert, M. K. (2025). Cellular miRNAs and viruses: trends in miRNA sequestering and target de-repression. Journal of Virology, e00914-25.
Prabsattru, P., Nakbua, T., Sengphairogh, S., Kitkumthorn, N., & Meevassana, J. (2025). Methylation of LINE-1 and Alu repetitive sequence in keloid. Scientific Reports, 15(1), 31994.
Puspitasari, M. K., Irianti, S., Pramatirta, A. Y., Wirawan, W., Islamy, N., Maelissa, M. M., & Lumentut, A. M. (2025). Folate Metabolism and Its Implications in Pregnancy. Journal La Medihealtico, 6(2), 285–298.
Ragusa, M. A., Gentile, C., Nicosia, A., Costa, S., Volpes, S., Greco, L., Naselli, F., & Caradonna, F. (2025). Epigenetic Remodeling of Regulatory Regions by Indicaxanthin Suggests a Shift in Cell Identity Programs in Colorectal Cancer Cells. International Journal of Molecular Sciences, 26(13), 6072.
Rehman, S. U., Abdullah, M., Khan, Z. K., & Shurovi, M. (2025). The role of DNA methylation and histone modifications in the pathogenesis of hematological malignancies and solid cancers: mechanisms, clinical implications, and therapeutic potential. Asian Journal of Medical and Biological Research, 11(2), 23–36.
Reynolds, C. M., & Vickers, M. H. (2019). Early Life Developmental Programming of the GH/IGF Axis and Long-Term Health. In Early Life Origins of Ageing and Longevity (pp. 67–86). Springer.
Reynolds, E. H. (2025). Folate, vitamin B12, one carbon metabolism and the nervous system. Journal of the Neurological Sciences, 123627.
Rodenburg, W. S., Strom, A. R., & Eeftens, J. M. (2025). Heterogeneity as a feature: unraveling chromatin’s role in nuclear mechanics. Nucleus, 16(1), 2545037.
Rondanelli, M., Borromeo, S., Cavioni, A., Gasparri, C., Gattone, I., Genovese, E., Lazzarotti, A., Minonne, L., Moroni, A., & Patelli, Z. (2025). Therapeutic strategies to modulate gut microbial health: approaches for chronic metabolic disorder management. Metabolites, 15(2), 127.
Roy, S. (2025). Regulation of Gene Expression by Chemical Modifications. In Gene Expression and its Regulation: An Evolutionary Perspective (pp. 181–209). Springer.
Roy, S., & Ghosh, M. K. (2025). Ubiquitin proteasome system (UPS): a crucial determinant of the epigenetic landscape in cancer. Epigenomics, 17(9), 625–644.
Sadia, K., Castagna, A., Udali, S., Ambrosani, F., Pattini, P., Beri, R., Argentino, G., Masutti, M., Moruzzi, S., & Friso, S. (2025). Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma. Cells, 14(17), 1337.
Saha, D., Kanjilal, P., Kaur, M., Menon, S. V, Ashraf, A., Kumar, M. R., Alqahtani, T., Atteri, S., Uti, D. E., & Dhara, B. (2025). Transforming Cancer Diagnostics: The Emergence of Liquid Biopsy and Epigenetic Markers. MedComm, 6(9), e70388.
Salavoura, A. (2025). Metals and Disease. In Chemical Environmental Pollutants and their Effect on Health (pp. 55–214). Springer.
Sangha, V. (2025). Novel Approaches for Effective Folate Delivery in Cerebral Folate Deficiency Disorders. University of Toronto (Canada).
Shadfar, A. (2025). Characterization of metabolic safeguarding factors in the context of direct cellular reprogramming. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky.
Shokrollahi, B., Park, M., Jang, G.-S., Jin, S., Moon, S.-J., Um, K.-H., Jang, S.-S., & Baek, Y.-C. (2025). Maternal Overnutrition in Beef Cattle: Effects on Fetal Programming, Metabolic Health, and Postnatal Outcomes. Biology, 14(6), 645.
Shu, Q., Liu, Y., & Ai, H. (2025). The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease. Cells, 14(4), 307.
Singh, M., Priya, K., Nagar, A., & Nalavade, R. (2025). Emerging landscape of lncRNA-miRNA interactions as architects of gene expression patterns. Molecular Biology Reports, 52(1), 1–15.
Smith, Z. D., Hetzel, S., & Meissner, A. (2025). DNA methylation in mammalian development and disease. Nature Reviews Genetics, 26(1), 7–30.
Song, J., Yang, P., Chen, C., Ding, W., Tillement, O., Bai, H., & Zhang, S. (2025). Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance. Signal Transduction and Targeted Therapy, 10(1), 219.
Souza, A. P. de, Marinho, V., & Marques, M. R. (2025). The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance. Epigenomes, 9(3), 23.
Sun, Y.-H., Zhang, J.-X., Jin, H.-S., & Huang, J. (2025). Crosstalk Between Metabolic Reprogramming and Epigenetic Modifications in Colorectal Cancer: Mechanisms and Clinical Applications. Current Issues in Molecular Biology, 47(9), 751.
Tang, J., Zhuang, Y., Zhang, Y., Hu, H., Wang, H., Xu, H., Li, Y., & Tu, C. (2025). Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications. Journal of Hematology & Oncology, 18(1), 77.
Theis, B. F., Park, J. S., Kim, J. S. A., Zeydabadinejad, S., Vijay-Kumar, M., Yeoh, B. S., & Saha, P. (2025). Gut feelings: How microbes, diet, and host immunity shape disease. Biomedicines, 13(6), 1357.
Tian, W., Ju, J., Guan, B., Wang, T., Zhang, J., Song, L., & Xu, H. (2025). Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside. Annals of Medicine, 57(1), 2457527.
Triantaphyllopoulos, K. A., Ragia, N. D., Panagiotopoulou, M.-C. E., & Sourlingas, T. G. (2025). Integrating Inflammatory and Epigenetic Signatures in IBD-Associated Colorectal Carcinogenesis: Models, Mechanisms, and Clinical Implications.
Vaidya, H., Jelinek, J., & Issa, J.-P. J. (2025). DNA Methylation, Aging, and Cancer. Epigenomes, 9(2), 18.
Van Dijck, E., Van Laere, S., Logie, E., Timmermans, S., Fransen, E., Ibrahim, J., Kendall, T. J., Fallowfield, J. A., Mateiu, L. M., & Libert, C. (2025). Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration. Clinical Epigenetics, 17(1), 138.
Verma, A., & Lindroth, A. M. (2025). The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer. Experimental & Molecular Medicine, 1–12.
Vickram, S., Infant, S. S., Sivasubramanian, M., Anbalagan, S., Marimuthu, M. M. C., & Chopra, H. (2025). Epigenetic modulation in cancer drug discovery: promising targets and clinical applications. Pharmacological Reports, 1–20.
Vlasac, I., Christensen, B. C., & Salas, L. A. (2025). Normal gastric tissue Helicobacter pylori infection is associated with tissue cell composition, and cell type–specific epigenetic age acceleration, mitotic tick rate, and repetitive element methylation alterations. Epigenetics Reports, 3(1), 2554836.
Vujić, A. (n.d.). Targeting DNA methylation and histone modifications using CRISPR/dCas9 tools in the regulation of glycosyltransferases gene expression of HepG2 cells.
Wallace, T. C., Cowan-Pyle, A. E., Klatt, K. C., & Bailey, R. L. (2025). Relationship of Choline Intake with Biomarkers of Liver Health by Genotype–A Cross-Sectional Analysis. The Journal of Nutrition, 155(6), 1970–1977.
Wang, Y., Huang, Z., Jin, C., Shen, X., He, X., & Yang, C. (2025). Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis. PLoS One, 20(7), e0305517.
Williams, S., Clark, S. J., Pidsley, R., & Stirzaker, C. (2025). DNA methylation biomarkers for the diagnosis and treatment management of breast cancer: where are we now? Epigenomics, 1–16.
Xiao, J., Qin, X., Chen, W., Que, X., Ma, Y., Huang, W., Ou, H., Bao, Y., Qu, L., & Shan, S. (2025). Immunoinflammation and post-translational modifications in the aging process. Journal of Translational Medicine, 23(1), 910.
Xing, Z., & Tu, B. P. (2025). Mechanisms and rationales of SAM homeostasis. Trends in Biochemical Sciences, 50(3), 242–254.
Yan, C., He, B., Wang, C., Li, W., Tao, S., Chen, J., Wang, Y., Yang, L., Wu, Y., & Wu, Z. (2025). Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway. Critical Reviews in Food Science and Nutrition, 1–24.
Yan, X., & Liu, C. (2025). The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting. Cell Death Discovery, 11(1), 390.
Yildiz, M. (2025). Epigenetic Mechanisms in Heart Diseases. Reviews in Cardiovascular Medicine, 26(7), 38696.
Youngson, N. A., Tourna, A., Chalmers, T., Prates, K. V, Argemi, J., Bataller, R., Haghighi, K. S., Wu, L. E., Chokshi, S., & Starkel, P. (2025). Multi-Cohort Exploration of Repetitive Element Transcription and DNA Methylation in Human Steatotic Liver Disease. International Journal of Molecular Sciences, 26(12), 5494.
Yun, P., Kulaixijiang, K., Pan, J., Yang, L., Wang, N., Xu, Z., Zhang, Y., Cai, H., Zhao, Z., & Zhu, M. (2025). Early colorectal cancer diagnosis: A novel methylated stool DNA model enhanced the diagnostic efficiency. United European Gastroenterology Journal, 13(3), 402–415.
Yusoff, N. A., Abd Hamid, Z., Taib, I. S., Abdul Razak, S. R., & Budin, S. B. (2025). Exploring epigenetic complexity in regulation of hematopoietic stem cells niche: a mechanistic journey from normal to malignant hematopoiesis.
Zainuddin, M.-S., Ghanesh, K., Ganesan, N., Kumari, M., Radhakrishnan, A. K., & Bhuvanendran, S. (2025). Epigenetic modulations and nutrient interactions in Alzheimer’s disease: unveiling potential therapeutic pathways. Nutritional Neuroscience, 1–23.
Zhang, X., Liu, D., Chen, X., Li, T., & Wu, G. (2025). Chromatin and epigenetic regulation in malignant tumors: A comprehensive review. Annals of the New York Academy of Sciences.
Zhou, R., Zhu, Z., Wang, Z., Dong, M., Huang, L., Wang, S., Zhang, X., & Liu, F. (2025). Association between MTHFR polymorphisms and vitamin D status in infertile women: a mediation analysis. Frontiers in Nutrition, 12, 1644302.
Zhou, W., & Reizel, Y. (2025). On correlative and causal links of replicative epimutations. Trends in Genetics, 41(1), 60–75.
Zwart, N. R. K., Kok, D. E., Ariyaratne, S. N. H., & McKay, J. A. (2025). Folate‐Associated DNA Methylation and Chemotherapy‐Induced Toxicities in Patients With Colorectal Cancer. Molecular Nutrition & Food Research, e70127.
Find the perfect home for your research! If this journal isn't the right fit, don't worry—we offer a wide range of journals covering diverse fields of study. Explore our other journals to discover the ideal platform for your work and maximize its impact. Browse now and take the next step in publishing your research:
| HOME | Yasin | AlSys | Anwarul | Masaliq | Arzusin | Tsaqofah | Ahkam | AlDyas | Mikailalsys | Edumalsys | Alsystech | AJSTEA | AJECEE | AJISD | IJHESS | IJEMT | IJECS | MJMS | MJAEI | AMJSAI | AJBMBR | AJSTM | AJCMPR | AJMSPHR | KIJST | KIJEIT | KIJAHRS |