Optimasi Sifat Fisik Gel Variasi Konsentrasi Lidah Buaya dan Karbopol 940 dalam Pembuatan Basis Gel Optimization of the Physical Properties of Gel with Varying Concentrations of Aloe Vera and Carbopol 940 in Gel Base Formulation
Article Sidebar
Page Numbers:
2401-2410
Digital Object Identifier:
10.58578/masaliq.v5i5.7171
Viewed: 953 times
Downloaded: 594 times
LYAS Publisher cordially invites qualified professionals to serve as Editors or Reviewers. Your expertise will make an important contribution to maintaining and strengthening the academic quality of our publications. Interested applicants are kindly requested to complete the application form at the following link: Editors & Reviewers
Please feel free to contact us if you need any further information about the submission process or if you have any additional questions.
Authors:
Welni Rahmadani1*, Fitri Amelia2 
Copyright :
Authors retain copyright and grant the journal right of first publication.
Main Article Content
Abstract
Gel is a topical dosage form commonly used to treat acne, with carbopol 940 widely utilized as a gel base due to its ability to produce a clear gel with high viscosity at low concentrations (0.5–2%). This study aims to analyze variations in the concentrations of Aloe vera and carbopol 940 that result in a physically stable gel formulation. The gel was formulated using Aloe vera at concentrations of 1%, 2%, 3%, 4%, and 5%, and carbopol 940 at 0.5%, 1%, 1.5%, and 2%. Evaluation parameters included pH, adhesion, spreadability, and homogeneity tests. The results show that various combinations of Aloe vera and carbopol 940 produced gel preparations that met physical stability requirements, with the optimal formulation containing 0.5 grams of carbopol exhibiting good physical stability in terms of adhesion, spreadability, and homogeneity. These findings indicate the potential of Aloe vera and carbopol 940 as effective base ingredients for producing stable acne gel formulations that meet quality standards.
Downloads
Article Details
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
Aditya Yanuarda1, P. and D. R. 1. (2015). The Effect Of Aloe Barbadensis Miller Gel Concentration As Stabilizers On Ice Ice Cream From Viscosity, Overrun, Melting Rate And Total Solids. Proceedings of the National Academy of Sciences, 3(1), 1–15.
Ardini, D., & Rahayu, P. (2019). Studi Variasi Gelling Agent PVA (Propil Vinil Alkohol) pada Formulasi Masker Peel-Off Ekstrak Lidah Buaya (Aloe vera) sebagai Anti Jerawat. Jurnal Kesehatan, 10(2), 245. https://doi.org/10.26630/jk.v10i2.1422
Caron, J., & Markusen, J. R. (2016). Formulasi Gel Tabir Surya Ekstrak Daun Teh Hijau (Camelia Sinensis) Dan Penentuan Nilai Sun Protection Factor (SPF). 4(2), 1–23.
Danimayostu, A. A., Shofiana, N. M., & Permatasari, D. (2017). Pengaruh Penggunaan Pati Kentang ( Solanum tuberosum ) Termodifikasi Asetilasi-Oksidasi sebagai Gelling agent terhadap Stabilitas Gel Natrium Diklofenak. Journal of International Society of Preventive and Community Dentistry, 3(1), 25–32. https://doi.org/10.15236/ijcpd.2017.13.2.67.
Dhurhania, C. E. (2019). Penetapan Kadar Metilparaben dan Propilparaben dalam Hand and Body Lotion secara High Performance Liquid Chromatography. Jurnal Farmasi (Journal of Pharmacy), 1(1), 38. https://doi.org/10.37013/jf.v1i1.12
Fujiastuti, T., & Sugihartini, N. (2015). Physical Properties and Irritation Degree of Etanolic Extract Gel pf Centella asiatica L. With Variation of Type of Gelling Agent. Pharmacy Medical, 12(01), 11–20.
Juli, V. N., Farmasi, P. S., Matematika, F., Alam, P., Jl, A., Kampus, R., Sel, K. K., & Badung, K. (2025). Optimasi Jumlah Karbopol 1 , 5 %, Triethanolamine , dan Air terhadap Sifat Fisik Emulgel Astaxanthin dan Ekstrak Wortel dan vitamin C ( Sulastri dkk ., 2021 ).
Khan, A. W., Kotta, S., Ansari, S. H., Sharma, R. K., Kumar, A., & Ali, J. (2013). Formulation development, optimization and evaluation of aloe vera gel for wound healing. Pharmacognosy Magazine, 9(36), S6–S10. https://doi.org/10.4103/0973-1296.117849
Kurnia Dian, & Ratnapuri Prima Happy. (2019). Review: Aktivitas Farmakologi Dan PerkembanganProduk Dari Lidah Buaya (Aloe vera L.). Jurnal Pharmascience, 6(1), 38–49.
Lumentut, N., Edi, H. J., & Rumondor, E. M. (2020). Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya. Jurnal MIPA, 9(2), 42. https://doi.org/10.35799/jmuo.9.2.2020.28248
Rahayu, T., Fudholi, A., & Fitria, A. (2016). Optimasi Formulasi Gel Ekstrak Daun Tembakau (Nicotiana Tabacum) Dengan Variasi Kadar Karbopol940 Dan Tea Menggunakan Metode Simplex Lattice Design (Sld). Jurnal Ilmiah Farmasi, 12(1), 22–34. https://doi.org/10.20885/jif.vol12.iss1.art3
Sánchez, M., González-Burgos, E., Iglesias, I., & Gómez-Serranillos, M. P. (2020). Pharmacological update properties of aloe vera and its major active constituents. Molecules, 25(6). https://doi.org/10.3390/molecules25061324
Sandala, E. R. F., Siampa, J. P., & Abdullah, S. S. (2024). Formulasi Sediaan Hidrogel Daun Miana (Coleus Scutellarioides (L.) Benth) : Uji Stabilitas Fisik dan Uji SPF. Jurnal Kesehatan Tambusai, 5(3), 6847–6856.
Sari, D. E. M., Yudanti, G. P., Fitrianingsih, S., Hidayati, R., & Zahro, D. F. (2024). Variasi Guar Gum Dan Karbopol 940 Sebagai Gelling Agent Terhadap Uji Sifat Fisik Dan Kimia Sediaan Gel Ekstrak Etanol 96% Buah Salak (Salacca Zalacca). Cendekia Journal of Pharmacy, 8(1), 71–87. https://doi.org/10.31596/cjp.v8i1.268
Sumule, A., Kuncahyo, I., & Leviana, F. (2020). Optimasi Carbopol 940 dan Gliserin dalam Formula Gel Lendir Bekicot (Achatina fulica Ferr) sebagai Antibakteri Staphylococcus aureus dengan Metode Simplex Lattice Design. Pharmacy: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 17(1), 108. https://doi.org/10.30595/pharmacy.v17i1.5640
Suzalin, F., Marlina, D., & Agustini, S. (2021). Formulasi dan Evaluasi Gel Antijerawat Ekstrak Daun Jeringau Hijau (Acorus Calamus L.) Dengan Variasi Konsentrasi Carbopol 940 Sebagai Gelling Agent. JKPharm Jurnal Kesehatan Farmasi, 3(1), 7–16. https://doi.org/10.36086/jpharm.v3i1.901
Thomas, N. A., Tungadi, R., Hiola, F., & S. Latif, M. (2023). Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera). Indonesian Journal of Pharmaceutical Education, 3(2), 316–324. https://doi.org/10.37311/ijpe.v3i2.18050
Tsabitah, A. F., Zulkarnain, A. K., Wahyuningsih, M. S. H., & Nugrahaningsih, D. A. A. (2020). Optimasi Carbomer, Propilen Glikol, dan Trietanolamin Dalam Formulasi Sediaan Gel Ekstrak Etanol Daun Kembang Bulan (Tithonia diversifolia). Majalah Farmaseutik, 16(2), 111. https://doi.org/10.22146/farmaseutik.v16i2.45666
Wulansari, S. A., Umarudin, U., & Sa’diyah, L. (2022). Pengaruh Variasi Jenis dan Konsentrasi Gelling Agent Terhadap Karakteristik Fisik Emulgel Koenzim Q10. Journal of Experimental and Clinical Pharmacy (JECP), 2(2), 161. https://doi.org/10.52365/jecp.v2i2.464
Yasir, A. S., Marcellia, S., Wijaya, L. B., & Putri, T. R. (2021). Formulasi dan Uji Aktivitas Gel Kombinasi Ekstrak Etanol Daun Lidah Buaya (Aloe vera) dan Daun Kemangi (Ocinum sanctum L.) Sebagai Anti Jetawat Terhadap Bakteri Staphylococcus epidermidis. Pharmacoscript, 4(1), 70–86. https://doi.org/10.36423/pharmacoscript.v4i1.610