Biochemical Integration of Chemically Modified Carbon Nanotubes

Main Article Content

Akpor Ugochukwu Blessed

Abstract

Carbon nanotubes (CNTs) have attracted growing interest in recent years for their small size, ordered structure, and distinctive surface and atomic configurations that enable applications across biomedicine and materials science. The objective of this study is to synthesize current knowledge on CNTs, how they are defined, classified, arranged, and synthesized; their unique properties; and their applications and risks with emphasis on drug delivery and broader biomedical uses. Methodologically, the paper conducts a literature-based review of CNT properties and uses, including their roles as carriers for therapeutic molecules (e.g., peptides), biosensors, and components in molecular electronics and composite materials, as well as hazards, regulatory considerations, and medical status. Key findings indicate that CNTs are promising, biocompatible, and supportive materials for transporting therapeutics owing to their internal cavity and ease of coating with biocompatible chemicals; they can be readily taken up by cell membranes and have been reported to deliver drugs directly to cancer cells. Beyond biomedicine, CNTs’ structural and surface features support their application as biosensors and in molecular electronics and composite formulations. The study concludes that CNTs offer substantial potential for targeted drug delivery and multimodal biomedical uses while requiring careful consideration of hazards and regulatory frameworks. The contribution and implication are a consolidated overview that highlights largely untapped opportunities for CNTs in biological research and clinical translation alongside the need for systematic evaluation of safety and oversight.

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Article Details

How to Cite
Blessed, A. U. (2025). Biochemical Integration of Chemically Modified Carbon Nanotubes. MASALIQ, 5(5), 2558-2577. https://doi.org/10.58578/masaliq.v5i5.7459

References

Agnieszka, L., Jeff, P., Lukasz, K., John, B. and Krzysztof, K. (2014). Electrical properties of Carbon Nanotube Based Fibres and their Future Use in Electrical Wiring. Advanced Functional Materials. 24(24):3661-3682.
Akira, T., Ko, B., Taishi N., Akihito, F., Takahiro, K., Takahito, N., Yuhei, M. and Kenichiro, I. (2019). Strength of carbon nanotubes depends on their chemical structures. Nature Communications. 10:3040.
Ali, E., Hadis, D., Hamzeh, K., Mohammad, K., Nosratollah, Z., Abolfazi, A., Mozhgan, A., Younes, H. and Sang, W. (2014). Carbon Nanotubes: properties, synthesis, purification, and medical applications. Nanoscale Research letters. 9:2.
Cheap Tubes (2021). Carbon Nanotubes Properties and Applications. [Online] Available at: https://www.cheaptubes.com/carbon-nanotubes-properties-and-applications/#biomedical. [Accessed 16th April 2021].
Anzar, N., Hasan, R., Tyagi, M., Yadav, N. and Narang, J. (2020). Carbon nanotube - A review on Synthesis, Properties and plethora of applications in the field of biomedical science. Sensors International. 1.
Aravind, K., Krithiga, T. and Venkatesan, D. (2020). Carbon nanotubes: synthesis, properties and applications. 21st Century Surface Science.
Awasthi, K., Srivastava, A. and Srivastava, O. (2005). Synthesis of carbon nanotubes. Nanoscience and Nanotechnology. 5:1616-1636.
Barnes, B., Brozena, A. and Wang, Y. (2019). Chemically tailored carbon nanotubes as a new toolbox for biomedicine and beyond. Elements in Biochemistry. pp 10.
Baughman, R. H., Zakhidov, A. A. and de Heer. W. A. (2002). Carbon nanotubes: the route toward applications. Science. 297(5582):787-792.
Bhargava, A. (1999). Nanorobots: medicine of the future.. [Online] Available at: http://www.ewh.ieee.org/r10/Bombay/news3/Page4.html [Accessed 16 April 2021].
Bian, Z. (2004). Carbon-nanotube-ceramic composites. Ceramic Nanomaterials and Nanotechnology. 2(14):69-82.
Bockrath, M. (2006). Carbon nanotubes: The weakest link. Nature Physics. 2(3):155-156.
Boczkowski, J. and Lanone, S. (2007). Potential uses of carbon nanotubes in the medical field: how worried should patients be? Nanomedicine. 2(4):407-410.
Bottini, M., Bruckner S., Nika, K., Bottini, N. and Bellucci, S. (2006). Full-length single-walled carbon nanotubes decorated with streptavidin conjugated quantum dots as multivalent intracellular fluorescent nanoprobes. Biomacromolecules. 7(8):2259-63.
Calvert, P. (1999). Nanotube composites: a recipe for strength. Nature. 399(6733):210-211.
Cavalcanti, A. (2007). Nanorobots for laparoscopic cancer surgery. International Conference on Computer and Information Science. 1(1):738-743.
Cummings, J. and Zettle, A. (2000). Low-friction nanoscale linear bearing realized from multiwall carbon nanotubes. Science. 289:602–604.
Danne, N., Kim, M., Godin, A., Kwon, H., Gao, Z., Wu, X., Hartman N., Doorn, S., Lounis, B., Wang, Y. and Cognet, L. (2018). Ultrashort carbon nanotubes that fluoresce brightly in the nearinfrared. American Chemical Society Nano. 12:6059–6065.
Bekyarova, E., Ni, Y., Malarkey, E., Montana, V., McWilliams J., Haddon, R. and Parpura V. (2005). Applications of carbon nanotubes in biotechnology and biomedicine. Journal of Biomedical Nanotechnology. 1:3–17.
Gao, M., Dai, L., Baughman R.H., Spinks, G.M., Wallance and G.G. (2000). Electrochemical properties of aligned nanotube arrays: Basis of new electrochemical actuators. Proceedings of Society of Photo-Optical Instrumentaion Engineers. 3987:18-24.
He, M., Nie, C., Yi, J., Zhang, J., Chen, T. and Chu, X. (2021). mRNA-Activated Multifunctional DNAzyme Nanotweezers for Intracellular mRNA Sensing and Gene Therapy. American Chemical Society Applied Materials and Interfaces. 13(7):8015-8025.
Hepzebah S., Prakash, N., Devaroshini, A., Sandhiya, A. and Sneha, P. (2020). Review on Blue Brain Technology-A Novel Tool for Studying Brain and Brain Related Disorders. 9(12):2278-0181.
Hong, G., Diao, S., Antaris, A. and Dai, H. (2015). Carbon nanomaterials for biological imaging and nanomedicinal therapy. American Chemical Society Chemical Reviews. 115:10816–10906.
Ishigami, N., Ago, H., Imamoto, K., Tsuji, M., Iakoubovskii, K, and Minami, N. (2008). Crsytal-Plane Dependent Growth of Aligned Single-Walled Carbon Nanotubes on Sapphire. Journal of the American Chemical Society. 130(30):9918-9924.
Kaur, R., Vatta, P. and Mandeep, K. (2018). Carbon Nanotubes: A Review Article. International Journal for Research in Applied Science & Engineering Technology. 6(4):2321-9653.
Kiernan, G., Barron, V., Blond, D., Drury, A., Coleman, J., Murphy, R., Cadek, M. and Blau, W. (2002). Characterization of nanotube based artificial muscle materials. Proceedings of Society of Photo-Optical Instrumentaion Engineers. 4876:775-782.
Kim, P. and Lieber, C. M. (1999). Nanotube nanotweezers. Science. 286:2148–2150.
Kodi, B. (2017). The Man-Machine-Man(M 3) Interfacing with the Blue Brain Technology. International Journal of Current Trends in Engineering and Research (IJCTER). 3(7):1-6.
Kong, Y., Cui, D., Ozkan, C.S. and Gao, H. (2003). Modeling carbon nanotube based bionano systems: a molecular dynamics study. In: Proceedings of Materials Research Society Symposium. 773:111–116.
Naha, S. and Ishwar, K. (2008). A model for catalytic growth of Carbon Nanotubes. Journal of Physics: Applied Physics. 41(6).
Padridge, M. (2005). The blood-brain barrier bottleneck in brain drug development. National library of Medicine. 2(1):3-14.
Penman, D. (2003). Carbon nanotubes show drug delivery promise. Newscientist.com [online]; http://www.new scientist.com/ article. ns? id=dn4485 & print=true (accessed 6 August 2009).
Stevens, R.M.D, Frederick, N.A., Smith, B.L., Morse, D.E., Stucky, G.D., Hansma, P.K. (2000). Carbon nanotubes as probes for atomic force microscopy. Nanotechnology. 11(1):1–5.
Ramesh, S. (2020). Blue Brain: A New Form of Life. Journal of Critic Reviews. 7(17):2092-2096.
Rautioa, J. and Chikhale P. (2004). Drug Delivery Systems for Brain Tumor Therapy. 10(12).
Sahoo, S. and Labhasetwar, V. (2003). Nanotech approaches to drug delivery and imaging. Drug Discovery Today. 8(24):1112-1120.
Sarwar, B., Mohammad, R., Asif, M., Saquib, H., Khalid, A. and Kanchan, K. (2010). Advancement in carbon nanotubes: basics, biomedical applications and toxicity. Journal of Pharmacy and Pharmacology. 63:141-163.
University of California (2005). Smart Bionanotubes Developed; May help in drug delivery. ScienceDaily. [Online] Available at www.sciencedaily,com/releases/2005/08/050802182805.html
Murakami, T., Fan, J., Yudasaka, M., Iijima, S. and Shiba, K. (2006). Solubilization of Single-Wall Carbon Nanohorns Using a PEG-Doxorubicin Conjugate. Molecular Pharmaceutics. 3(4):407-414.
Tulin, M. (2009). Bio-inspired and Nanoscale Integrated Computing. Biomedical and Biomedicine applications of Carbon Nanotubes. pp 483-508.
Vohrer, U., Kolaric, I., Haque, M., Roth, S. and Detlaff-Weglikowska, U. (2004). Carbon nanotube sheets for use as artificial muscles. Carbon. 42:316-319.
Wu, W. (2005). Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes. Angewandte Chemie International Edition in English. 44:6358–6362.

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