Chemical Constituents and Bioactivities of Azanza garckeana: A Review
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146-160
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Authors:
Stephen Dio Titus1*, Nelson Christian2, Kennedy B. Samuel3, Samuel G. Ishaya4, Achilus Francis5, Ajiduku Abershi Leyoa6 
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Abstract
Azanza garckeana, commonly known as "Goron Tula," is a medicinal plant widely recognized in Southern Africa for its traditional applications in treating infertility, respiratory issues, and liver disorders. Recent studies have explored its bioactive compounds, revealing significant therapeutic potentials, such as antiplasmodial, antioxidant, anti-inflammatory, and uterotonic effects. Key phytochemicals like flavonoids, tannins, and alkaloids have been identified, contributing to its diverse pharmacological activities. This review compiles current knowledge on the chemical constituents and bioactivities of Azanza garckeana, providing a foundation for future research on its medicinal and nutritional applications. The plant's role in enhancing health, with potential uses in modern medicine, is also highlighted.
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References
Ahmad, A., Suleiman, I., Abdulazeez, J., & Yusuf, T. (2022). Effect of Hydromethanolic Fruit Pulp Extract of Azanza garckeana (Malvaceae) on Sexual Behavior, Sex Hormones and Histology of Female Wistar Rats. International Journal of Research and Reports in Gynaecology, 5(3), 181-192.
Ahmed, M. U., Ignatus, M., Yakubu, B., Umaru, I. J., Muhammad, Z. I., Habibu, B., Okoli, C. E., & Yusufu, D. (2022). Alpha amylase and angiotensin converting enzyme inhibitory potential of aqueous extract of Azanza garckeana fruit. Journal of Applied and Natural Science, 14(2), 3305. DOI: 10.31018/jans.v14i2.3305.
Ahmed, M. U., Umaru, I. J., Bazza, J. A., & Adamu, A. A. (2024). Effect of Aqueous Fruit Extract of Azanza garckeana on Some Biochemical and Hematological Parameters in Wistar Rats. Advances in Biological Sciences, 2(4), 298-303. DOI: 10.3923/asb.2024.298.303.
Ajiboso, S. O. (2023). Determination of chemical profile of Azanza garckeana Fruit. International Journal of Recent Research in Thesis and Dissertation, 4(2), 1-6.
Amaduruonye, W., Ikwunze, K., Charles, P. C., & Egbo, A. B. (2024). Direct and Residual Effect of Azanza garckeana (Goron Tula) Fruit Meal on Lipid Profiles of New Zealand White Rabbits in the Humid Tropics. Nigerian Journal of Animal Production, 488-492.
Amaduruonye, W., Uche, C. D., Charles, P. C., Herbert, U., Obike, O. M., Onunkwo, D. N., ... & Odoemelan, L. E. (2024). Direct and residual effects of Azanza garckeana (Goron tula) fruit on the Growth and Internal organ histology of New Zealand White rabbit bucks. Journal of Sustainable Veterinary & Allied Sciences, 6(1).
Asghariazar, V., Karimi, A., Adeli, S., Kadkhodayi, M., Zare, E., Azgoomi, R. N. D., & Vostakolaei, M. A. (2024). Anticancer activity of naringenin on human liposarcoma: An experimental and bioinformatic study. Prostaglandins & Other Lipid Mediators, 174, 106884.
Asogwa, E. U., & Asogwa, U. E. (2020). The role of fruits in human nutrition: An overview. Food Science and Human Wellness, 9(3), 193-198.
Balogun, P. O., Hassan, O. N., & Raji, I. S. AROC in Natural Products Research 2021; 1 (2): 1-10.
Benhura, M. A., Mbuya, N., & Machirori, E. (1999). Facile formation of caramel colours using the polysaccharide material that is extracted from the fruit of Azanza garckeana. Food chemistry, 65(3), 303-307.
Bioltif, Y. E., Edward, N. B., & Tyeng, T. D. (2020). A chemical overview of Azanza garckeana. Biology, medicine, & natural product chemistry, 9(2), 91-95.
Broughton Pipkin, F., & Thilaganathan, B. (2018). Uterine contractility and the mechanisms of labor. Current Opinion in Obstetrics and Gynecology, 30(6), 460-465.
Brubacher, J. (2002). A review of the analytical methods for the determination of ascorbic acid in food. Food Chemistry, 78(4), 577-582.
Bukar, B. B., Ezeh, F., & Sabo, S. Y. (2021). Methanol extract of Azanza garckeana fruit pulps protects against formalin-induced reproductive toxicity in adult albino male mice. health, 3, 4.
Bukar, B. B., Tsokwa, N. E., & Orshi, O. D. (2020). Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice. Journal of Pharmacy & Bioresources, 17(2), 164-173.
Chanda, A., Angela Gono-Bwalya, A., & Prashar, L. (2024). The Phytopharmacological Evaluation of the Methanol Root Extract of Azanza garckeana (Malvaceae) on Isolated Wistar Rat Uterine Smooth Muscles. bioRxiv, 2024-05. DOI: 10.1101/2024.05.10.593648.
Chanda, A., Simwinga, F., Kaonga, P., Gono-Bwalya, A., & Prashar, L. (2020). The uterotonic screening of the root extract of Azanza garckeana (malvaceae) on isolated Wistar rat uterine smooth muscles. Evidence‐Based Complementary and Alternative Medicine, 2020(1), 8873180.
Chawafambira, A. (2021). Extraction and characterization of pectin from snot apple (Azanza garckeana) fruits with potential use in Zimbabwe. International Journal of Fruit Science, 21(1), 791-803.
Connelly, M. P. E., Fabiano, E., Patel, I. H., Kinyanjui, S. M., Mberu, E. K., & Watkins, W. M. (1996). Antimalarial activity in crude extracts of Malawian medicinal plants. Annals of Tropical Medicine & Parasitology, 90(6), 597-602. https://doi.org/10.1080/00034983.1996.11813089
Danbature, W. L., Yirankinyuki, F. F., Magaji, B., & Ibrahim, Z. (2015). Comparative determination of vitamin C and iron in ten (10) locally consumed fruits in Gombe State, Nigeria. International Journal of Advanced Research in Chemical Sciences, 2(8), 14-18.
Dawud, F. A., Farrau, U., Abdulkadir, T. S., Augustine, B. D., Jaafar, A., Itodo, O. D., ... & Mudassir, M. S. (2023). Acute and subacute oral toxicity of methanol fruit pulp extract of Azanza garckeana (Tula Kola nut) in adult male Wistar rats. Nigerian Journal of Biochemistry and Molecular Biology, 38(1), 20-32.
Dehelean, C. A., Marcovici, I., Soica, C., Mioc, M., Coricovac, D., Iurciuc, S., ... & Pinzaru, I. (2021). Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy. Molecules, 26(4), 1109.
Dikko, Y., Khan, M., Tor-Anyiin, T., Anyam, J., & Linus, U. (2016). In vitro antimicrobial activity of fruit pulp extracts of Azanza garckeana (F. hoffm.) Exell & Hillc. and isolation of one of its active principles, betulinic acid. British Journal of Pharmaceutical Research, 14(1), 1-10.
Dong, M., Ming, X., Xiang, T., Feng, N., Zhang, M., Ye, X., ... & Wu, Q. (2024). Recent research on the physicochemical properties and biological activities of quinones and their practical applications: a comprehensive review. Food & Function, 15(18), 8973-8997.
Ehigiator, B. E., Okoli, R. I., Ndubueze, N. G., & Ebong, O. O. (2021). In-vivo and In-silico Investigations on Goron Tula (Azanza garckeana F. Hoffm), a Booster of Female Sexual Arousal and Vaginal Lubrication. J Trop Dis doi, 10.
El Oirdi, M. (2024). Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy. Pharmaceuticals, 17(6), 692.
El Rayess, Y., Nehme, N., Azzi-Achkouty, S., & Julien, S. G. (2024). Wine phenolic compounds: Chemistry, functionality and health benefits. Antioxidants, 13(11), 1312.
Esmeeta, A., Adhikary, S., Dharshnaa, V., Swarnamughi, P., Maqsummiya, Z. U., Banerjee, A., ... & Duttaroy, A. K. (2022). Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomedicine & Pharmacotherapy, 153, 113384.
Farrau, U., Dawud, F. A., Abdulkadir, T. S., Augustine, B. D., Jaafar, A., Egbunu, V. U. O., ... & Salman, M. (2024). Dysregulation of Electrolyte Balance and Lipid Profile in Rats Following Oral Administration of Methanolic Fruit Pulp Extract of Azanza garckeana (Tula Kola Nut).
Felix, J. O., Nkwocha, C. C., & Oruchukwu, M. L. (2024). Assessment of Nutrients, Antinutrients and In Vitro Antioxidants Studies of Whole Leaf, and Leaf Extract of Azanza garckeana.
Gaobotse, G., Venkataraman, S., Brown, P. D., Masisi, K., Kwape, T. E., Nkwe, D. O., ... & Makhzoum, A. (2023). The use of African medicinal plants in cancer management. Frontiers in Pharmacology, 14, 1122388.
Gaur, P. K., Rastogi, S., & Lata, K. (2022). Correlation between phytocompounds and pharmacological activities of Boerhavia diffusa Linn with traditional-ethnopharmacological insights. Phytomedicine Plus, 2(2), 100260.
Hassan, A. I., & Aminu, A. I. (2024). Evaluation of the Antimicrobial Activity and Toxicity of Local and Foreign Seeds of Azanza garckeana (Goron Tula) Extracts. UMYU Journal of Microbiology Research (UJMR), 9(1), 1-14.
Herbert, U., Amaduruonye, W., Ikwunze, K., Obike, O. M., Onunkwo, D. N., Amaechi, N., & Odoemelan, L. E. (2024). Growth and Linear Body Developments of New Zealand White rabbit bucks fed diets supplemented with Azanza garckeana (Goron Tula) fruit meal. Nigerian Journal of Animal Production, 50(3), 125-138.
Hlabano, N., Nkiwane, L. C., Dzingai, P., & Gadlula, S. (2024). Proximate analysis and evaluation of total phenolic compounds in Azanza garckeana fruit for use as gelatin crosslinking agent. Journal of Food Science and Technology, 61(2), 342-350. https://doi.org/10.1007/s11483-024-01750-2
Ibrahim, M., Idoko, A. S., & Ganiyu, A. I. (2024). Evaluation of the acute and sub-acute toxicity of Azanza garckeana aqueous leaves extract in wistar rats. Nigerian Journal of Biochemistry and Molecular Biology, 39(1), 8-15.
Ibrahim, M., Idoko, A. S., Ganiyu, A. I., & Sadiq, I. Z. Hypoglycaemic and Anti-hyperglycaemic Activity of Aqueous Extract of Azanza garckeana Leaves in Normal and Alloxan-induced Diabetic Rats.
Ibrahim, M., Idoko, A. S., Ganiyu, A. I., Lawal, N., Abu, P., Ifebu, J., ... & Yusuf, F. (2023). Phytochemical analysis of Hexane, Chloroform, Ethyl acetate, Ethanol and Aqueous Extracts of Azanza garckeana Leaf. Sahel Journal of Life Sciences FUDMA, 1(1), 25-31.
Ibrahim, P., Abdurahman, E. M., & Bisallah, M. (2019). Pharmacognostic evaluation of the leaves of Azanza garckeana (F. Hoffm.) Exell et Hillc.(Malvaceae). Journal of Pharmacy & Bioresources, 16(2), 125-132.
Ikechi-Nwogu, C. G., & Egere, M. U. (2024). Macroscopic and Molecular Approaches for Identification of Fungi Associated with Azanza garckeana. Asian J. Biol. Sci, 17(3), 324-330.
Ikechi-Nwogu, C. G., & Egere, M. U. (2024). Macroscopic and Molecular Approaches for Identification of Fungi Associated with Azanza garckeana. Asian J. Biol. Sci, 17(3), 324-330.
Iloabuchi, G. C., Idoko, A. S., Hannafi, A. M., Ganiyu, A. I., & Umar, S. (2024). Effects of Azanza garckeana Fruit Pulp on Metabolic Syndrome in Wistar Rats Fed on High Fructose Diet. UMYU Journal of Microbiology Research (UJMR), 9(1), 55-64.
Itodo, J. I., Ayo, J. O., Rekwot, I. P., Aluwong, T., Allam, L., & Ibrahim, S. (2022). Comparative evaluation of solvent extracts of Azanza garckeana fruit pulp on hormonal profiles, spermiogram and antioxidant activities in rabbit bucks. World Rabbit Science, 30(4), 309-326.
Itodo, J. I., Jolayemi, K. O., Sani, D., Ocheja, J. O., Ibrahim, S., & Ojeamiren, M. T. (2023). Effects of Azanza garckeana and melatonin on serum biochemical and histopathological changes induced by chronic bisphenol-A administration in New Zealand rabbit bucks. Emerging Animal Species, 9, 100031.
Itodo, Joy Iyojo, Peter Ibrahim Rekwot, Tagang Aluwong, Lushaikyaa Allam, Kelvin Olutimilehin Jolayemi, Stephen Kyari, Kenneth Owoicho Abah et al. "Azanza garckeana ameliorates Bisphenol A-induced reproductive toxicities in rabbit bucks." Theriogenology 192 (2022): 150-165.
Itojo, J. I., Rekwot, P. I., Aluwong, T., Lushiakyaa, A., Bugau, J. S., Ojeamiren, M. T., Umar, M. D., Mundi, L. H., Abdullahi, H. R., & Yusuf, A. T. (2022). Comparative roles of Azanza garckeana (Goron Tula) and melatonin in ameliorating chronic exposure to bisphenol A on testicular morphometry and sperm reserves in New Zealand white bucks. Nigerian Journal of Animal Production, 560-563.
Iyen, I. S., Ushie, O. A., Ugwuja, D. I., Longbap, B. D., & Ayila, D. N. (2021). Chemical composition and antimicrobial activities of methanol extract of Azanza garckeana fruit pulp. J. Sci. Eng. Technol, 8(1), 143-150.
Iyojo, I. J., Ibrahim, R. P., Tagang, A., Allam, L., & Olusegun, A. J. (2022). Effects of different extracts of Azanza garckeana fruit pulp on haematological and biochemical parameters of New Zealand White (NZW) rabbit bucks. Comparative Clinical Pathology, 31(3), 453-463.
Jacob, C., Shehu, Z., Danbature, W. L., & Karu, E. (2016). Proximate analysis of the fruit Azanza garckeana (“Goron Tula”). Bayero Journal of pure and applied sciences, 9(2), 221-224.
Janowska, S., Holota, S., Lesyk, R., & Wujec, M. (2024). Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs. Molecules, 29(2), 346.
Joel, J. M., Barminas, J. T., Riki, E. Y., Yelwa, J. M., & Edeh, F. (2018). Extraction and characterization of hydrocolloid pectin from goron tula (Azanza garckeana) fruit. World Sci. News, 101, 157-171.
Jolly, A., Hour, Y., & Lee, Y. C. (2024). An outlook on the versatility of plant saponins: a review. Fitoterapia, 105858.
Kaur, S., Mendonca, P., & Soliman, K. F. (2024). The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer. Nutrients, 16(15), 2392.
Lashani, K., Malik, S., Gaobotse, G., Makhzoum, A., & Masisi, K. (2024). Exploring nature’s Pharmacy: Indigenous Plants of Southern Africa with Antiallergic Properties and their Mechanism of Action. In Biotechnology of Medicinal Plants with Antiallergy Properties: Research Trends and Prospects (pp. 127-154). Singapore: Springer Nature Singapore.
Lawal, B., Kuo, Y. C., Onikanni, S. A., Chen, Y. F., Abdulrasheed-Adeleke, T., Fadaka, A. O., ... & Huang, H. S. (2023). Computational identification of novel signature of T2DM-induced nephropathy and therapeutic bioactive compounds from Azanza garckeana. American Journal of Translational Research, 15(7), 4504.
Lawal, B., Sani, S., Onikanni, A. S., Ibrahim, Y. O., Agboola, A. R., Lukman, H. Y., ... & Conte-Junior, C. A. (2022). Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents. Biomedicine & Pharmacotherapy, 152, 113196.
Laz-OkenwaJOA, A. T. F., & Ojeka, S. O. (2024). Evaluation of the phytochemical/active ingredients composition of the hydroethanol extract of the fruit pulp of Azanza garckeana and its toxicity profile. Journal of Medicinal Plants Studies. 12(1): 38-42
Letcher, R. M., & Shirley, I. M. (1992). O-Naphthoquinones from the heartwood of Azanza garckeana. Phytochemistry, 31(12), 4171-4172. https://doi.org/10.1016/0031-9422(92)80436-I
Ma, Z., Du, B., Li, J., Yang, Y., & Zhu, F. (2021). An insight into anti-inflammatory activities and inflammation related diseases of anthocyanins: A review of both in vivo and in vitro investigations. International Journal of Molecular Sciences, 22(20), 11076.
Madkour, D. A., Ahmed, M., Elkirdasy, A. F., Orabi, S. H., & Mousa, A. A. (2024). Rutin: Chemical properties, Pharmacokinetic properties and Biological activities. Matrouh Journal of Veterinary Medicine, 4(1), 26-34.
Magaji, P. A., Muhammad, A., & Shadrach, P. (2024). Antioxidant Activities and FT-IR of Azanza garckeana Leaves Extracts. African Journal of Biochemistry and Molecular Biology Research, 1(1), 459-470. https://doi.org/10.58578/ajbmbr.v1i1.3486
McCarty, M. F., O'Keefe, J. H., & DiNicolantonio, J. J. (2019). Glucosamine for the treatment of osteoarthritis: the time has come for higher-dose trials. Journal of dietary supplements, 16(2), 179-192.
Michael, K. G., Onyia, L. U., & Jidauna, S. B. (2015). Evaluation of phytochemicals in Azanza garckeana (Gorontula) seed. Journal of Agriculture and Veterinary Science, 8(5), 71-74.
Michael, K. G., Onyia, L. U., & Kefas, M. (2015). Growth performance of Clarias gariepinus juveniles fed with Azanza garckeana (goron tula) seed meal. 91-97.
Mohammed, A. H., Mshelia, E. H., Watirahyel, E. M., & Yohanna, C. (2021). Phytochemicals Screening and Antimicrobial Activity of the Stem Bark Extracts of Azanza garckeana (Kola of Tula). Scientific Journal of Pure and Applied Sciences, 4(6), 154-164. DOI: 10.36348/sijtcm.2021.v04i06.010.
Mojeremane, W., & Tshwenyane, S. (2004). Azanza garckeana: A valuable edible indigenous fruit tree of Botswana.
Mokwena, K. K. (2024). Englerophytum Magalismontanum Sond. TD Penn (Sapotaceae): A Review of Its Botany, Nutritional Profile and Ethnomedicinal Potential. Int. J. Sci. Res. in Multidisciplinary Studies Vol, 10(2).
Momodu, I. B., Okungbowa, E. S., Agoreyo, B. O., & Maliki, M. M. (2022). Gas chromatography–mass spectrometry identification of bioactive compounds in methanol and aqueous seed extracts of Azanza garckeana fruits. Nigerian Journal of Biotechnology, 38(1), 25-38.
Mshelia, E.H., Watirahyel, E.M., Maigari, A.U., Christopher, Y., & Ismail, F. (2023). Cytotoxicity and Antioxidant Activity of Stem Bark Extracts of Azanza garckeana (Kola of Tula). Journal of Chemistry.
Mucha, P., Skoczyńska, A., Małecka, M., Hikisz, P., & Budzisz, E. (2021). Overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes. Molecules, 26(16), 4886.
Mudge, S. M. (2005). Fatty alcohols—a review of their natural synthesis and environmental distribution. The Soap and Detergent Association, 132, 1-141.
Nascimento, M. M. D., & Oliveira, L. D. (2015). A modified method for iron determination in biological samples using spectrophotometry. Analytical Chemistry, 87(5), 2761-2766.
Nayak, B. N., Singh, R. B., & Buttar, H. S. (2022). Biochemical and dietary functions of tryptophan and its metabolites in human health. In Functional foods and nutraceuticals in metabolic and non-communicable diseases (pp. 783-798). Academic Press.
Ngcobo, A., Mianda, S. M., Seke, F., Sunette, L. M., & Sivakumar, D. (2024). Phytonutritional Composition and Antioxidant Properties of Southern African, Purple-Fleshed Sweet Potato (Ipomoea batatas (L.) Lam.) Storage Roots. Antioxidants, 13(3), 338.
Nkafamiya, I., Ardo, B., Osemeahon, S., & Akinterinwa, A. (2016). Evaluation of nutritional, non-nutritional, elemental content and amino acid profile of Azanza garckeana (Goron Tula). British Journal of Applied Science & Technology, 12(6), 1-10.
Nko, K. I., Mwinga, J. L., Asong, J. A., Venter, S. L., Amoo, S. O., & Aremu, A. O. (2025). Cultural Perspectives, Nutritional and Health Values of Wild Edible Plants among the Batswana of Southern Africa. In Food Security and Nutrition (pp. 216-241). CRC Press.
Nkwocha, C. C., Felix, J. O., Michael, L. O., & Ale, B. A. (2024). Phytochemical screening and GC-FID identification of bioactive compounds in n-hexane, ethylacetate and methanol fractions of methanolic leaves extract of Azanza garckeana. Food Chemistry Advances, 4, 100712.
Nurudeen, Q. O., Asinmi, M. R., Falana, M. B., Dikwa, M. A., Yusuf, Z. M., & Lambe, M. O. (2024). Antioxidant activity and toxicological implications of the aqueous extract of Azanza garckeana fruit pulp in female wistar rats. Nigerian Journal of Biochemistry and Molecular Biology, 39(1), 1-7.
Obia, O., Ezekiel-Hart, H., Laz-Okenwa, J. O. A., Reuben, E., Dan-Jumbo, D., & Wami-Amadi, C. F. (2024). The effect of hydro-methanolic seed extract of Azanza garckeana (Goron Tula) on lipid profile and oxidative stress markers of male Wistar rats. International Journal of Medical Evaluation and Physical Report, 8(5), 83-89. DOI: 10.56201/ijmepr.v8.no5.2024.pg83.89
Ochokwu, I. J., Dasuki, A., & Oshoke, J. O. (2015). Azanza garckeana (Goron Tula) as an edible indigenous fruit in North Eastern Part of Nigeria. Journal of Biology, Agericulture and Healthcare, 5(15), 26-31.
Ochokwu, I. J., Nwabunike, M. O., & Udeh, G. N. (2019). Evaluation of milt quality of Clarias anguillaris (Linnaeus, 1758) broodstock fed varying inclusion levels of wild hibiscus Azanza garckeana pulp meal. Journal of Aquatic Sciences, 34(1), 23-31. DOI: https://dx.doi.org/10.4314/jas.v34i1.4
Okwu, D. E. (2001). Evaluation of the chemical composition of the leaves of Ocimum gratissimum L. and Thymus vulgaris L. as spices. Journal of Medicinal Plants Research, 5(5), 751-754.
Oraeluno, J. N., Obasi, J. C., Bamigbola, E. A., & Joseph, B. A. (Year). Extraction and evaluation of the binding properties of pectin derived from Azanza garckeana fruit in diclofenac sodium-based tablet. International Journal of Modern Pharmaceutical Research, 5(3), 144-147.
Raimi, C. O., Jimoh, A. O., & Oyeyemi, A. M. (2024). Performance of broiler chicken fed diets supplemented with Azanza garckeana (snot apple). International Journal of Innovative Research and Reviews, 8(1), 1-5.
Rajendran, M. (2016). Quinones as photosensitizer for photodynamic therapy: ROS generation, mechanism and detection methods. Photodiagnosis and photodynamic therapy, 13, 175-187.
Salih, A. M., Al-Qurainy, F., Tarroum, M., Shaikhaldein, H. O., & Hashimi, A. (2022). Screening and Estimation of Bioactive Compounds of Azanza garckeana (Jakjak) Fruit Using GC-MS, UV–Visible Spectroscopy, and HPLC Analysis. Separations, 9(7), 172.
Simon, L. D., Iliya, J. C., Abraham, P., & Umar, M. U. (2021). Bio-active potential of African chewing gum (Azanza garckeana) aqueous leaf extract on second stage juvenile mortality of root-knot nematode (Meloidogyne incognita). Interdisciplinary Journal of Applied and Basics Subjects, 1(11), 45-51.https://identifier.visnav.in/1.0002/ijabs-21k-16012/
Sirajo, K., Shehu, Z., Binanci, M. U., Mas' ud, I., & Dirk, A. A. (2022). Study of Proximate Composition of Seed and Peel of (Azanza garckeana) Goron Tula. Asian Journal of Food Research and Nutrition, 1(2), 35-40.
Souza, S. L., Silva, C. M., Gomes, D. A., Barros, W. A., Castro, R. M., & Alves, S. M. (2024). Tryptophan Metabolism in Developmental Origins of Health and Disease (DOHaD).
Suleiman Jada, M., Umar, Y., & Usman Wurochekke, A. (2024). Antiplasmodial activity of Azanza garckeana root bark extract and its effect on hematological indices in plasmoduim berghei infected mice. Journal of Research in Applied and Basic Medical Sciences, 10(3), 213-223.
Sulieman, A. M. E. H. (2019). Azanza garckeana L.: Distribution, Composition, Nutritive Value, and Utilization. Wild Fruits: Composition, Nutritional Value and Products, 379-393.
Suliman, A. M. E., Difa, I. Y., & Salih, Z. A. (2012). The nutritive value of jakjak (Azanza garckeana l.) fruit and its utilization in juice production. Asian J. Biol. Sci, 5(4), 209-215.
Ushie, O. A., Iyen, I. S., Aasegh, T. J., Ama, S. O., Aikhoje, E. F., & Shamaki, H. A. (2022). Phytochemical screening and antimicrobial activities of hexane extract of Azanzagarckeana. Research Journal of Pharmaceutical, Chemical and Biological Sciences (RJPCBS), 3(2), 007-012.
Varagani, S., Kumar, M. U., Ahamad, T., Athul, H., Gomasa, M., Haque, M., ... & Dhanya, P. V. (2024). Role of Glucosamine and Hyaluronic acid in the treatment of Osteoarthritis. Int. J. Adv. Res. Biol. Sci, 11(7), 112-126.
Veiko, A. G., Lapshina, E. A., & Zavodnik, I. B. (2021). Comparative analysis of molecular properties and reactions with oxidants for quercetin, catechin, and naringenin. Molecular and Cellular Biochemistry, 476(12), 4287-4299.
Virginia, F., Cathrine, L., & Fernandez, S. (2024). Isolation, purification, and characterization of betulin, a pentacyclic triterpenoid from the ethanolic extracts of Coleus forskohlii tuberous roots; its antimicrobial, antioxidant, anti-inflammatory and cytotoxicity appraisals.: Phytochemistry. Moroccan Journal of Chemistry, 12(4), 1531-1553.
Yasmin, H. E., & Mahdi, A. M. A. (2020). Preliminary phytochemical screening, antibacterial and antioxidant activities of Azanza garckeana (Fruits). GSC Biological and Pharmaceutical Sciences, 11(3), 125-129.
Yin, J., Zhao, D., Song, J., Gao, R., Wang, X., Rao, H., ... & Hao, J. (2024). Synergistic Antioxidant Activity of Lycium barbarum Polysaccharide and Chlorogenic Acid and Its Effect on Inflammatory Response of NR8383 Cells. Foods, 13(22), 3696.
Yusuf, A. A., Lawal, B., Alozieuwa, U. B., Onikanni, A. S., Lukman, H. Y., Fadaka, A. O., ... & Fouad, D. (2023). Attenuating effects of Azanza garckeana fractions on glycemo-impaired-associated dyslipidemia, hepatopathy, and nephropathy. American Journal of Translational Research, 15(10), 5997.
Yusuf, A. A., Lawal, B., Sani, S., Garba, R., Mohammed, B. A., Oshevire, D. B., & Adesina, D. A. (2020). Pharmacological activities of Azanza garckeana (Goron Tula) grown in Nigeria. Clinical Phytoscience, 6, 1-8.
Yusuf-Omoloye, N. A., Adeyemi, F. M., Sule, W. F., Azeez, L., Oyedara, O. O., Wahab, A. A., ... & Lateef, A. (2024). Green-synthesis, characterization, and antibacterial activity of Azanza garckeana seed extract silver nanoparticles against vancomycin-resistant Enterococci. Next Nanotechnology, 6, 100035.
Zakawa, N. N., Yusuf, C. S., Oyebanji, E. O., Timon, D., Isa, A., Bala, U., & William, N. Nigerian Journal of Botany Journal/Nigerian Journal of Botany/Vol. 34 No. 1 (2021)/Articles Open Access.