Culturally Responsive AI-Supported Cancer Pain Education: A Human-Centered Framework for Multilingual Oncology Care
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Abstract
Cancer pain education aims to help patients understand pain, communicate symptoms, and follow clinician-approved management plans; however, improved knowledge does not consistently translate into reduced pain intensity. Generative artificial intelligence (AI) is increasingly proposed for patient-facing education, while evidence supporting culturally and linguistically responsive oncology applications remains limited. This critical perspective develops a human-centered framework for AI-supported cancer pain education in multilingual oncology care. A focused, non-systematic critical synthesis integrated research on cancer pain education, health literacy, cultural adaptation, multilingual communication, and AI governance. No primary data were collected. The framework proposes six interdependent design domains: patient-led co-design and cultural humility; multilingual, accessible, dialogic learning; accurate pain science that avoids reductionist explanations; clearly bounded, evidence-grounded AI functions; explicit human oversight and escalation procedures; and lifecycle governance with equity-focused evaluation. These domains constitute conceptual recommendations requiring empirical evaluation. A staged evaluation pathway progresses from co-design and cognitive testing to offline AI benchmarking, supervised usability pilots, and comparative implementation studies. Initial evaluations should prioritize comprehension, communication, trust, safety, and access across language groups. Potential effects on pain interference and other clinical outcomes remain hypotheses for prospective testing. Illustrative examples involving Moroccan Darija highlight linguistic and cultural adaptation challenges without establishing cancer-specific validation. The proposed AI role is restricted to educational support and does not encompass diagnosis, prescribing, psychotherapy, professional interpretation, or replacement of oncology professionals. By connecting health education, cultural responsiveness, pain science, and responsible AI governance, the framework provides a basis for developing and evaluating multilingual educational support. Its contribution lies in specifying design and evaluation priorities while retaining clinical effectiveness as an open empirical question.
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References
Abeo, A. N. A., Armstrong, S., Scriney, M., & Goss, H. (2025). Artificial intelligence techniques and health literacy: A systematic review. Mayo Clinic Proceedings: Digital Health, 3(4), Article 100269. https://doi.org/10.1016/j.mcpdig.2025.100269
Akdemir, A., Smith, A. B., Wu, V. S., Rincones, O., Russell, H., Lyhne, J. D., Kemp, E., David, M., & Bamgboje-Ayodele, A. (2024). Guided versus non-guided digital psychological interventions for cancer patients: A systematic review and meta-analysis of engagement and efficacy. Psycho-Oncology, 33(1), Article e6290. https://doi.org/10.1002/pon.6290
Andersen, B. L., Lacchetti, C., Ashing, K., Berek, J. S., Berman, B. S., Bolte, S., Dizon, D. S., Given, B., Nekhlyudov, L., Pirl, W., Stanton, A. L., & Rowland, J. H. (2023). Management of anxiety and depression in adult survivors of cancer: ASCO guideline update. Journal of Clinical Oncology, 41(18), 3426–3453. https://doi.org/10.1200/JCO.23.00293
Arana-Chicas, E., Zhang, Y., Chávez-Iñiguez, A., Lin, P.-J., Mattick, L. J., Kamen, C., Clark, V., Cartujano-Barrera, F., & Mustian, K. M. (2025). Use of cultural appropriateness strategies and behavioral frameworks in behavioral interventions for Black and Hispanic cancer survivors: A systematic review. BMC Cancer, 25, Article 835. https://doi.org/10.1186/s12885-025-14182-0
Aydin, S., Karabacak, M., Vlachos, V., & Margetis, K. (2024). Large language models in patient education: A scoping review of applications in medicine. Frontiers in Medicine, 11, Article 1477898. https://doi.org/10.3389/fmed.2024.1477898
Boumendil, K., Iderdar, Y., Al Wachami, N., Arraji, M., Najmi, S., Hawkins, M., Osborne, R., & Chahboune, M. (2026). Translation and cultural adaptation of the health literacy questionnaire (HLQ) in Morocco. Journal of Patient-Reported Outcomes, 10, Article 149. https://doi.org/10.1186/s41687-026-01111-3
Brewster, R. C. L., Tse, G., Fan, A. L., Elborki, M., Newell, M., Gonzalez, P., Hoq, A., Chang, C., Chowdhury, M., Geeti, A., Hana, M., Hassan, H., Ibrahim, O., Keseyan, L., Li, Q., Mamoon, M., Nageye, M., Ohannessian, A., Eisenberg, I. R., … Khan, A. (2025). Evaluating human-in-the-loop strategies for artificial intelligence-enabled translation of patient discharge instructions: A multidisciplinary analysis. npj Digital Medicine, 8, Article 629. https://doi.org/10.1038/s41746-025-02055-6
Busch, F., Hoffmann, L., Rueger, C., van Dijk, E. H. C., Kader, R., Ortiz-Prado, E., Makowski, M. R., Saba, L., Hadamitzky, M., Kather, J. N., Truhn, D., Cuocolo, R., Adams, L. C., & Bressem, K. K. (2025). Current applications and challenges in large language models for patient care: A systematic review. Communications Medicine, 5, Article 26. https://doi.org/10.1038/s43856-024-00717-2
Chen, D., Avison, K., Alnassar, S., Huang, R. S., & Raman, S. (2025). Medical accuracy of artificial intelligence chatbots in oncology: A scoping review. The Oncologist, 30(4), Article oyaf038. https://doi.org/10.1093/oncolo/oyaf038
Choi, S., & Choi, J. (2021). Effects of the teach-back method among cancer patients: A systematic review of the literature. Supportive Care in Cancer, 29(12), 7259–7268. https://doi.org/10.1007/s00520-021-06445-w
Costas-Muniz, R., Torres-Blasco, N., Gany, F., Gonzalez, C. J., Galindo-Vazquez, O., Bergerot, C. D., Rocha-Cadman, X., Lui, F., Lichtenthal, W. G., Velazquez, A. I., Tergas, A. I., & Castro-Figueroa, E. M. (2023). Cultural adaptation process of cancer-related interventions: A step-by-step guide. Psycho-Oncology, 32(1), 179–186. https://doi.org/10.1002/pon.6071
Damschroder, L. J., Reardon, C. M., Widerquist, M. A. O., & Lowery, J. (2022). The updated Consolidated Framework for Implementation Research based on user feedback. Implementation Science, 17, Article 75. https://doi.org/10.1186/s13012-022-01245-0
Dehpour, T., Wakefield, D., Luckett, T., Hussain, J., & Koffman, J. (2026). Patient-centred educational interventions for assessing and managing cancer-related pain relevant to minority ethnic populations: A mixed-methods systematic review. Palliative Care and Social Practice, 20, Article 26323524261421936. https://doi.org/10.1177/26323524261421936
Fallon, M., Giusti, R., Aielli, F., Hoskin, P., Rolke, R., Sharma, M., & Ripamonti, C. I. (2018). Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Annals of Oncology, 29(Suppl. 4), iv166–iv191. https://doi.org/10.1093/annonc/mdy152
Galietta, E., Donati, C. M., Bazzocchi, A., Sassi, R., Zamfir, A. A., Hovenier, R., Bos, C., Hendriks, N., Boomsma, M. F., Huhtala, M., Blanco Sequeiros, R., Grüll, H., Ferdinandus, S., Verkooijen, H. M., & Morganti, A. G. (2025). Impact of pain education on pain relief in oncological patients: A narrative review of systematic reviews and meta-analyses. Cancers, 17(10), Article 1683. https://doi.org/10.3390/cancers17101683
González-Martín, A. M., Aguilera-García, I., Castellote-Caballero, Y., Rivas-Campo, Y., Bernal-Suárez, A., & Aibar-Almazán, A. (2023). Effectiveness of therapeutic education in patients with cancer pain: Systematic review and meta-analysis. Cancers, 15(16), Article 4123. https://doi.org/10.3390/cancers15164123
Hernández-Hernández, S., Heredia-Ciuró, A., Martín-Núñez, J., Calvache-Mateo, A., Navas-Otero, A., López-López, L., & Valenza, M. C. (2024). The impact of pain education interventions for cancer survivors and caregivers: A systematic review with meta-analysis. Cancers, 16(13), Article 2468. https://doi.org/10.3390/cancers16132468
Jeitani, C., Van den Broucke, S., & Leemans, C. (2025). Interventions addressing health literacy in cancer care: A systematic review of reviews. International Journal of Environmental Research and Public Health, 22(2), Article 212. https://doi.org/10.3390/ijerph22020212
Kamdar, M., Jethwani, K., Centi, A. J., Agboola, S., Fischer, N., Traeger, L., Rinaldi, S., Strand, J., Ritchie, C., Temel, J. S., Greer, J. A., Kvedar, J., El-Jawarhi, A., & Jackson, V. (2024). A digital therapeutic application (ePAL) to manage pain in patients with advanced cancer: A randomized controlled trial. Journal of Pain and Symptom Management, 68(3), 261–271. https://doi.org/10.1016/j.jpainsymman.2024.05.033
Khoubila, N., Bendari, M., Benmiloud, S., ElHoudzi, J., Maani, K., Elmouden, L., Alzemmouri, M., Hachim, J., Kili, A., Kababri, M., Khattab, M., ElBouri, H., Hassoune, S., Nani, S., Cherkaoui, S., Quessar, A., Madani, A., & Hessissen, L. (2020). Pain management in children with cancer: National surveys of practices and perceptions in Morocco. Open Access Macedonian Journal of Medical Sciences, 8(B), 723–730. https://doi.org/10.3889/oamjms.2020.5252
Leong, A., & Ormsby, K. (2026). Generative AI for patient education in cancer care: A scoping review of evaluation practices and emerging trends. Technical Innovations & Patient Support in Radiation Oncology, 37, Article 100373. https://doi.org/10.1016/j.tipsro.2025.100373
Liu, H., Hu, Y., Li, D., Shi, B., Niu, Y., Zhang, X., Zheng, G., Li, C., Wang, L., & Bao, Y. (2026). LLM-driven collaborative framework for knowledge-enhanced cancer pain assessment and management. npj Digital Medicine, 9, Article 180. https://doi.org/10.1038/s41746-026-02362-6
Llave, K., Cheng, K. K., Ko, A., Pham, A., Ericson, M., Campos, B., Perez-Gilbe, H. R., & Kim, J. H. J. (2024). Promising directions: A systematic review of psychosocial and behavioral interventions with cultural incorporation for advanced and metastatic cancer. International Journal of Behavioral Medicine, 31(6), 848–870. https://doi.org/10.1007/s12529-024-10264-8
Lui, F., Lewicka, M., Bao, G. C., Moyer, A., Boyce, L., & Leng, J. (2023). A systematic review and meta-analysis of psychosocial interventions for immigrant and limited English proficient cancer patients. Psycho-Oncology, 32(4), 516–557. https://doi.org/10.1002/pon.6110
Martínez-Miranda, P., Jiménez-Rejano, J. J., Muñoz-Fernández, M. J., García-Muñoz, C., & Casuso-Holgado, M. J. (2024). Effectiveness of an interactive online group intervention based on pain neuroscience education and graded exposure to movement in breast cancer survivors with chronic pain: A randomised controlled trial. Supportive Care in Cancer, 32(10), Article 705. https://doi.org/10.1007/s00520-024-08887-4
Nutbeam, D. (2000). Health literacy as a public health goal: A challenge for contemporary health education and communication strategies into the 21st century. Health Promotion International, 15(3), 259–267. https://doi.org/10.1093/heapro/15.3.259
Raja, S. N., Carr, D. B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefe, F. J., Mogil, J. S., Ringkamp, M., Sluka, K. A., Song, X.-J., Stevens, B., Sullivan, M. D., Tutelman, P. R., Ushida, T., & Vader, K. (2020). The revised International Association for the Study of Pain definition of pain: Concepts, challenges, and compromises. Pain, 161(9), 1976–1982. https://doi.org/10.1097/j.pain.0000000000001939
Raoui, A., El Ghalib, L., & Agoub, M. (2025). Psychological and social impact of announcing cancer diagnosis in a Moroccan university hospital oncology unit: A cross-sectional study. BMC Psychology, 13, Article 1417. https://doi.org/10.1186/s40359-025-03690-0
Sjattar, E. L., Arafat, R., & Ling, L. W. (2024). Cancer pain self-management interventions in adults: Scoping review. BMJ Supportive & Palliative Care, 14(4), 411–415. https://doi.org/10.1136/spcare-2024-004893
Snijders, R. A. H., Brom, L., Theunissen, M., & van den Beuken-van Everdingen, M. H. J. (2023). Update on prevalence of pain in patients with cancer 2022: A systematic literature review and meta-analysis. Cancers, 15(3), Article 591. https://doi.org/10.3390/cancers15030591
Sørensen, K., Van den Broucke, S., Fullam, J., Doyle, G., Pelikan, J., Slonska, Z., Brand, H., & (HLS-EU) Consortium Health Literacy Project European. (2012). Health literacy and public health: A systematic review and integration of definitions and models. BMC Public Health, 12, Article 80. https://doi.org/10.1186/1471-2458-12-80
Tabassi, E. (2023). Artificial intelligence risk management framework (AI RMF 1.0) (NIST AI 100-1). National Institute of Standards and Technology. https://doi.org/10.6028/NIST.AI.100-1
Talevski, J., Wong Shee, A., Rasmussen, B., Kemp, G., & Beauchamp, A. (2020). Teach-back: A systematic review of implementation and impacts. PLOS ONE, 15(4), Article e0231350. https://doi.org/10.1371/journal.pone.0231350
Tervalon, M., & Murray-García, J. (1998). Cultural humility versus cultural competence: A critical distinction in defining physician training outcomes in multicultural education. Journal of Health Care for the Poor and Underserved, 9(2), 117–125. https://doi.org/10.1353/hpu.2010.0233
Thind, B. S., & Tsao, C.-K. (2025). Artificial intelligence in oncology: Promise, peril, and the future of patient–physician interaction. Frontiers in Digital Health, 7, Article 1633577. https://doi.org/10.3389/fdgth.2025.1633577
Whitehead, L., Kirk, D., Chejor, P., Liu, W., Nguyen, M., Balczer, C., Lan, C., & Evans, M. (2025). Interventions, programmes and resources that address culturally and linguistically diverse consumer and carers’ cancer information needs: A mixed methods systematic review. BMC Cancer, 25, Article 599. https://doi.org/10.1186/s12885-025-13931-5
World Health Organization. (2021). Ethics and governance of artificial intelligence for health: WHO guidance. https://iris.who.int/handle/10665/341996
World Health Organization. (2024). Ethics and governance of artificial intelligence for health: Guidance on large multi-modal models. https://iris.who.int/handle/10665/375579
Zhang, Y., Flannery, M., Zhang, Z., Underhill-Blazey, M., Bobry, M., Leblanc, N., Rodriguez, D., & Zhang, C. (2024). Digital health psychosocial intervention in adult patients with cancer and their families: Systematic review and meta-analysis. JMIR Cancer, 10, Article e46116. https://doi.org/10.2196/46116
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