Analgesic and Anti-Inflammatory Effects of Ethanolic Seed Extract of Hunteria umbellata in Murine Models
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Abstract
Hunteria umbellata seeds are traditionally used to manage pain and inflammatory disorders. This study evaluated the acute oral toxicity, analgesic activity, and anti-inflammatory activity of an ethanolic extract of H. umbellata seeds in murine models. Acute oral toxicity was assessed using Lorke’s method. Analgesic activity was evaluated using acetic acid-induced writhing, formalin-induced nociception, and hot plate assays, while anti-inflammatory activity was assessed using carrageenan- and egg albumin-induced paw oedema models. No observable toxicity was reported at doses up to 5,000 mg/kg. The extract demonstrated significant analgesic and anti-inflammatory activities, reducing acetic acid-induced writhing and inhibiting both the neurogenic and inflammatory phases of formalin-induced nociception. It also prolonged reaction latency in the hot plate assay, suggesting a central component to its analgesic effects. Anti-inflammatory activity was demonstrated by reduced paw oedema in both the carrageenan and egg albumin models. These findings demonstrate the analgesic and anti-inflammatory potential of the ethanolic seed extract and provide preclinical support for the traditional use of H. umbellata seeds in managing pain and inflammatory disorders.
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