Prevalence of Epstein-Barr Virus in Some Women Suspected with Breast Cancer in Kaduna State, Nigeria

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Page Numbers: 409-420
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Published: Apr 6, 2025
Digital Object Identifier: 10.58578/mikailalsys.v3i2.5298
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Authors:
Kolo R. L.1*, Suleiman A. B.2, Whong C. M. Z.3, Elijah Ekah Ella4
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Kolo R. L.
Federal University Gashua Yobe State, Nigeria
Suleiman A. B.
Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Whong C. M. Z.
Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Elijah Ekah Ella
Ahmadu Bello University, Zaria, Kaduna State, Nigeria

Abstract

Epstein - Barr virus has been associated with several types of epithelial carcinomas; it promotes the oncogenic action of cultivated breast cancer cells through stimulation of HER2 signaling cascades. This work was aimed at determining the seroprevalence of EBV and some risk factors associated with the infection in some women suspected with breast cancer attending Ahmadu Bello University Teaching Hospital, Kaduna state, Nigeria. Serological screening for EBV antibodies was done using Enzyme Linked ImmunoSorbent Assay (ELISA) IgM. Of the one hundred and seventy eight patient samples, one hundred and seven patients were positive for EBV (60.1%). Highest prevalence of 71.7% was recorded in women in the age group 40-49 years old, 70.5% in women with secondary education. Married women in monogamous marriages had highest prevalence of 65.6% and 69.8% respectively. Highest prevalence of 67.2% was recorded in women who had children; women with 1-5 numbers of children also had highest prevalence of 74%. There was a significant association of EBV IgM seroprevalence (p<0.05) with marital status, having children and also number of children the women had. EBV is believed to be a leading contributor to Hodgkin lymphoma, and significant associations have been found between the frequency of Hodgkin lymphoma and breast cancer, which suggests that EBV may also promote some breast cancers.

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How to Cite
L., K. R., B., S. A., Z., W. C. M., & Ella, E. E. (2025). Prevalence of Epstein-Barr Virus in Some Women Suspected with Breast Cancer in Kaduna State, Nigeria. Journal of Multidisciplinary Science: MIKAILALSYS, 3(2), 409-420. https://doi.org/10.58578/mikailalsys.v3i2.5298
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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

References

Al-Moustafa, A.E., Al-Antary, N., Aboulkassim, T., Akil, N., Batist, G., & Yasmeen, A. (2016). Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer. Human Vaccines and Immunotherapeutics 12(7): 1936-1939. PMID: 27082145. DOI: 10.1080/21645515.2016.1139255.

Aminu, M., Muhammed, A., Magaji, S.J., Olaniyan, F.A., Usman, M.A., & Ella, E.E. (2021). Detection of Epstein-Barr Virus Antibodies in Some Nigerian Women with Breast Lumps. Archives of Basics and Applied Medicine, 9:19– 22.

Ascherio, A., Munger, K.L., Lennette, E.T., Spiegelman, D., Hernan, M.A., Olek, M.J., Hankinson, S.E., & Hunter, D.J. (2001). Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA. 286(24):3083–8. PMID: 11754673 doi: 10.1001/jama.286.24.3083.

Center for Disease Control (CDC), (2016). Epstein-Barr Virus and Infectious Mononucleosis. Available from: https://www.cdc.gov/epstein-barr/about-mono.html.

Crawford, D.H., Macsween, K.F., Higgins, C.D., Thomas, R., McAulay, K., Williams, H., Swerdlow, A.J., & Britton, K. (2006). A cohort study among university students: identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosis. Clinical Infectious Disease Journal. 43(3):276–82. https://doi.org/10.1086/505400

Crawford, D.H., Swerdlow, A.J., Higgins, C., McAulay, K., Harrison, N., Williams, H., Britton, K., & MacSween, K.F. (2002). Sexual History and Epstein-Barr virus Infection. Journal of Infectious Diseases, 186(6):731-736. ISSN 0022-1899 DOI: https://doi.org/10.1086/342596

GLOBOCAN 2020: UICC: New global cancer data. December 17, 2020. Available at www.uicc.org/news/globocan-2020-new-global-cancer-data. Accessed June 16, 2021.

Haeri, S., Baker, A.M., & Boggess, K.A. (2010). Prevalence of Epstein-Barr Virus Reactivation in Pregnancy. American Journal of Perinatology, 27(9):715-720. doi: 10.1055/s-0030-1253098.

Higgins, C.D., Swerdlow, A.J., Macsween, K.F., Harrison, N., Williams, H., McAulay, K., Thomas, R., Reid, S., Conacher, M., Britton, K., & Crawford, D.H. (2007). A Study of Risk Factors for Acquisition of Epstein-Barr virus and Its Subtypes. Journal of Infectious Diseases, 195(4):474-482. doi: 10.1086/510854.

Hoover, K., & Higginbotham, K. (2023). Epstein - Barr virus. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559285/

Huo, Q., Zhang, N., & Yang, Q. (2012). Epstein-Barr Virus Infection and Sporadic Breast Cancer Risk: A Meta-Analysis. PLoS One, 7(2):e31656. https://doi.org/10.1371/journal.pone.0031656

Johannsen, E., & Kaye, K. (2010). Epstein-Barr virus (Infectious Mononucleosis, Epstein-Barr Virus-Associated Malignant Disease and other Diseases) In: Mandell GL, editor. Mandell, Douglas, Benett’s Principles and practice of Infectious Diseases. 7th Ed. Philadelphia: Churchil Livingstone; 1989–2005. 138, 1872-1890.e7

Mazouni, C., Fina, F., Romain, S., Ouafik, L., Bonnier, P., Brandone, J.M., & Martin, P.M. (2011). Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. British Journal of Cancer. 104(2):332–337. doi: 10.1038/sj.bjc.6606048

Mentzer, A.J., Brenner, N., Allen, N., Littlejohns, T.J., Chong, A.Y., Cortes, A., Almond, R., Hill, M., Sheard, S., McVean, G., Collins, R., Hill, A.V.S., Waterboer, T., & UKB Infection Advisory Board (2022). Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank. Nature Communication. 13(1):1818. Doi: 10.1038/s41467-022-29307-3.

Nishiwaki, M., Fujimuro, M., Teishikata, Y., Inoue, H., Sasajima, H., & Nakaso, K. (2006). Epidemiology of Epstein-Barr virus, cytomegalovirus, and Kaposi’s sarcoma-associated herpesvirus infections in peripheral blood leukocytes revealed by a multiplex PCR assay. Journal of Medical Virology. 78(12):1635–42. doi: 10.1002/jmv.20748.

Oladimeji, K.E., Tsoka-Gwegweni, J.M., Igbodekwe, F.C., Twomey, M., Akolo, C., Balarabe, H.S., Atilola, O., Jegede, O., & Oladimeji, O. (2015). Knowledge and beliefs of breast self-examination and breast cancer among market women in Ibadan, South West, Nigeria. PloS one, 10(11):e0140904. https://doi.org/10.1371/journal.pone.0140904.

Papesch, M., & Watkins, R. (2001). Epstein-Barr virus infectious mononucleosis. Clinical Otolaryngology and Allied Science. 26(1):3–8. doi: 10.1046/j.1365-2273.2001.00431.x.

Santpere, G., Darre, F., Blanco, S., Alcami, A., Villoslada, P., Mar Albà, M., & Navarro, A. (2014). Genome-wide analysis of wild-type Epstein-Barr virus genomes derived from healthy individuals of the 1,000 genomes project. Genome Biology and Evolution. 6(4):846–60. doi: 10.1093/gbe/evu054.

Sinclair, A.J., Moalwi, M.H., & Amoaten, T. (2021). Is EBV associated with breast cancer in specific geographic locations? Cancers (Basel), 13(4): 819. doi: 10.3390/cancers13040819.

Tang, W., Harmon, P., Gulley, M.L., Mwansambo, C., Kazembe, P.N., & Martinson, F. (2010). Viral Response to Chemotherapy in Endemic Burkitt Lymphoma. Clinical Cancer Resource, 16(7):2055–2064. doi: 10.1158/1078-0432.CCR-09-2424.

Trottier, H., Buteau, C., Robitaille, N., Duval, M., Tucci, M. and Lacroix, J., & Alfieri, C. (2012). Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children. Transfusion. 52(12):2653–63. doi: 10.1111/j.1537-2995.2012.03611.x.

Tzellos, S., & Farrell, P.J. (2012). Epstein-Barr virus sequence variation-biology and disease. Pathogens. 1(2):156–74. doi: 10.3390/pathogens1020156.

World Health Organization (WHO), (2021). Breast cancer and the Nigerian Woman. https://healththink.org/breast-cancer-and-the-nigerian-woman/.

Yahia, Z.A., Adam, A.A., Elgizouli, M., Hussein, A., Masri, M.A., Kamal, M., Mohamed, H.S., Alzaki, K., Elhassan, A., Hamad, K., & Ibrahim, M.E. (2014). Epstein-Barr virus: a prime candidate of breast cancer etiology in Sudanese patients. Infectious Agent and Cancer, 9(1):9. doi: 10.1186/1750-9378-9-9

Yasui, Y., Potter, J.D., Stanford, J.L., Rossing, M.A., Winget, M.D., Bronner, M., & Daling, J. (2001). Breast cancer risk and “delayed” primary Epstein-Barr virus infection. Cancer Epidemiology Biomarkers Preview 10(1):9-16. PMID: 11205495

Young, L.S., Yap, L.F., & Murray, P.G. (2016). Epstein-Barr virus: more than 50 years old and still providing surprises. Nat Rev Cancer 16(12):789–802. doi: 10.1038/nrc.2016.92.

Yusuf, S. (2015). Kaduna: Physical and Human environment. Department of Geography, Kaduna State University, Kaduna. Published by Shanono Printers and Publishers Kaduna.

Zhang, W., Wang, M.Y., Wei, X.L., Lin, Y., Su, F.X., & Xie, X.M. (2017). Associations of Epstein-Barr virus DNA in PBMCs and the subtypes with breast cancer risk. Journal of Cancer. 8(15):2944–9. doi: 10.7150/jca.20330


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