Hepatoprotective Effect of Ethanolic Leaves Extract of Musa Paradisiaca on CCL4-Induced Hepatotoxicity in Albino Rats
Article Sidebar
Page Numbers:
456-466
Digital Object Identifier:
10.58578/ajstea.v3i2.5132
Viewed: 302 times
Downloaded: 187 times
LYAS Publisher cordially invites qualified professionals to serve as Editors or Reviewers. Your expertise will make an important contribution to maintaining and strengthening the academic quality of our publications. Interested applicants are kindly requested to complete the application form at the following link: Editors & Reviewers
Please feel free to contact us if you need any further information about the submission process or if you have any additional questions.
Authors:
Lazarus J. Goje1, Maryam U. Abdulkadir2, Abubakar M. Hammari3*, Ibrahim A. Adam4, Adamu J. Abubakar5, Kudih N. Mamman6, Abu-ubaida Haruna7, Abdullahi Muhammad8 
Copyright :
Authors retain copyright and grant the journal right of first publication.
Main Article Content
Abstract
Musa paradisiaca (banana) leaves have been extensively used in traditional medicine for the treatment and management of disorders related to oxidative stress, including diabetes, neurodegenerative diseases, and cancer. However, there is limited scientific evidence supporting these claims. This study aimed to evaluate the hepatoprotective and antioxidant properties of Musa paradisiaca leaf extract in albino rats with carbon tetrachloride (CCl₄)-induced liver damage. Fresh leaves of Musa paradisiaca were collected, shade-dried, and extracted using 60% ethanol. Thirty albino rats were randomly assigned to five groups: control, CCl₄-induced, CCl₄ + silymarin (100 mg/kg), CCl₄ + Musa paradisiaca extract (200 mg/kg), and CCl₄ + Musa paradisiaca extract (400 mg/kg). The extract was administered orally, while CCl₄ was given intraperitoneally (IP) to induce liver damage. Phytochemical screening of the extract revealed the presence of alkaloids, saponins, tannins, flavonoids, anthraquinones, and steroids. Liver function biomarkers—alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)—were analyzed spectrophotometrically. The results indicated that the Musa paradisiaca extract significantly reduced ALT, AST, and ALP levels (p ≤ 0.05) compared to the CCl₄-treated group, demonstrating its hepatoprotective effects. The 400 mg/kg dose exhibited a more pronounced effect, comparable to that of silymarin. These findings provide scientific validation for the traditional use of Musa paradisiaca leaves in managing liver disorders and conditions associated with oxidative stress. Further studies are recommended to isolate and characterize the bioactive compounds responsible for these effects.
Citation Metrics:
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
Abbas K, Rizwani G, Zahid H, Qadir M.I, (2017). Evaluation of Nephroprotective activity of Musa paradisiaca L in Gentamycin induced nephrotoxicity
Ahmad I., Beg A.Z. (2015) Antimicrobial and Physiological Studies on 45 Indian Medicinal Plants Against Multidrugs Resistant Human Pathogen. Journal of Ethnopharmacol, 74:113-123 Biochemical report vol.8, no 2018 pp 219-223.
Carvalho J.R., Machado M.V. (2018). New Insight about Albumin and Liver Disease Ann. Hepatol. 17, 547-560
Daniel Q. Huang, Norah A. Terrault, Frank Tacke, Lise Lotte Gluud, Marco Arrese, Elisabetta Gupta, A.K., & Pandey, A. (2018). Traditional Medicinal Uses of Banana Plant: A Review.
Hamza, H. G., Saleh, A.I, Mohammed, Z. K & Ngadda, H. A. (2014). Effect of Aqueous Extract of Detarium microcarpum ( Guill & Sperr ) on Mycotoxin- Induced Tissue Damage in albino rats. 9(10), Committee of Publication ethics ( COPE ) and Journal donation project ( JDP ). 629–633. https://doi.org/10.22271/phyto.2020.v9.i4i.112990.
Ketiku AO (2017). Chemical composition of unripe (green) and ripe plantain (Musa paradisiaca). J. Sci. Food Agr. 24(6):703–707.
Lewis, RJ (2017). Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3.
Mahmood, A; Ngah, N; Omar, MN (2018). Phytochemicals constituent and antioxidant activities in Musa x paradisiaca flower. European Journal of Scientific Research, 66(2):311-318.
Maisarah, A. M., Nurul Amira, B., Asmah, R., & Fauziah, O. (2013). Antioxidant analysis of different parts of Carica papaya. International Food Research Journal, 20(3), 1043–1048.
Marc G. Ghany (2019). Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.
Ozougwu Jevas C. (2017) Physiology of the Liver. Internal Journal in Pharmacy. Vol. 4. pp 13-24
Panigrahi, PN; Dey, S; Sahoo, M; Dan, A (2017). Antiurolithiatic and antioxidant efficacy of Musa paradisiaca pseudostem on ethylene glycol induced nephrolithiasis in rat. Indian journal of pharmacology, 49(1):77-83.
Reitman S., & Frankel, S. (1957) A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American journal of clinical pathology 28: 56–63. PMID: 13458125.
Ringehan M., McKealing J.A., Protzer U. (2017). Viral Hepatitis and Cancer. Philos. Trans, R Soc. B Biol. Sci. 372, 0-74.
Simonikova D. Nemeckova A., Cizkova J. Brown A., Swennen R., Dolezel J.,Hribova E.,(2020). Chromosome Painting in Cultivated Bananas and Their Relatives (Musa spp). Rveals Difference in Chromosome Structure. Int J Mol Sci. 21: 7915.
Targher, Manuel Romero-Gomez, Shira Zelber-Sagi, Vincent Wai-Sun Wong. (2020).
A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement Journal of Hepatology. Volume 73, Pages 202-209.