Phytochemical Composition, FT-IR Characterization, and In Vitro Antifungal Activity of Methanol Extract of Mitracarpus villosus
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Authors:Isma’il Abubakar1, Ibrahim Muhammad Adam2, Adamu Jauro Abubakar3, Ibrahim Muhammad Umar4, Abdurrahman Hussaini Muhammad5, Umar Abubakar Babajo6
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Abstract
This study investigated the phytochemical composition and antifungal potential of the methanol extract of Mitracarpus villosus, a medicinal plant traditionally used in Nigeria to treat microbial infections. Phytochemical screening identified terpenoids, flavonoids, tannins, and quinones, whereas phlobatannins were absent. The extract’s antifungal activity against Candida albicans, Aspergillus niger, and Aspergillus flavus was evaluated using the agar well diffusion method. The extract exhibited concentration-dependent antifungal activity, with the greatest inhibition observed against C. albicans (19 mm at 500 µg/mL), followed by A. niger and A. flavus. Fourier-transform infrared spectroscopy confirmed the presence of bioactive functional groups, including N–H, C=O, and –CHO, which are commonly associated with antimicrobial activity. These findings provide empirical support for the traditional use of M. villosus and indicate its potential as a source of natural antifungal agents. Further research should isolate and characterize the active compounds and evaluate their pharmacological profiles.
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References
Aboh, M. I., Oladosu, P., Adeshina, G. O., Olayinka, B. O., Olonitola, S., & Atasie, N. H. (2018). Screening of selected medicinal plants for their antifungal properties. African Journal of Clinical and Experimental Microbiology, 20(1), 54–59. https://doi.org/10.4314/ajcem.v20i1.8
Aboh, M. I., Olayinka, B. O., Adeshina, G. O., & Kolo, I. (2014). Preliminary studies on the antifungal activities of the successive extracts of Mitracarpus villosus (Sw.) DC aerial parts obtained in Abuja, Nigeria. Malaysian Journal of Microbiology, 10(2), 133–138.
Aboh, M. I., Olayinka, B. O., Adeshina, G. O., Oladosu, P., & Ibrahim, K. (2015). In vitro antifungal efficacies of ethyl acetate fractions of Mitracarpus villosus from Abuja, Nigeria. British Microbiology Research Journal, 7(3), 151–158. https://doi.org/10.9734/BMRJ/2015/15051
Chimbekujwo, K. I., & Ya’u, S. A. (2022). Phytochemical and antifungal activity of crude extracts of Mitracarpus scaber against some dermatophytes. International Research Journal of Advanced Engineering and Science, 7(2), 331–334. https://irjaes.com/wp-content/uploads/2022/06/IRJAES-V7N2P120Y22.pdf
Cimanga, R. K., Kambu, K., Tona, L., De Bruyne, T., Sandra, A., Totte, J., Pieters, L., & Vlietinck, A. J. (2004). Antibacterial and antifungal activities of some extracts and fractions of Mitracarpus scaber Zucc. (Rubiaceae). Journal of Natural Remedies, 4(1), 17–25. https://doi.org/10.18311/jnr/2004/376
Dauda, H., Uba, G., & Ali, U. (2020). Preliminary phytochemical screening, quantitative analysis of flavonoids from the stem bark extract of Commiphora africana (Burseraceae). Bulletin of Environmental Science and Sustainable Management, 4(1), 25–27. https://doi.org/10.54987/bessm.v4i1.529
Ekalu, A. (2021). Medicinal uses, phytochemistry, and pharmacological activities of Mitracarpus species (Rubiaceae): A review. Scientific African, 11, e00692. https://doi.org/10.1016/j.sciaf.2020.e00692
Ekwealor, C. C., Oyeka, C. A., & Okoli, I. (2012). Antifungal activities of some Nigerian medicinal plants against non-dermatophyte molds isolated from cases of onychomycosis among rice farmers in Anambra State, Nigeria. British Microbiology Research Journal, 2(2), 62–70. https://doi.org/10.9734/BMRJ/2012/1248
Goje, L. J., Abdulkadir, M. U., Hammari, A. M., Adam, I. A., Abubakar, A. J., Mamman, K. N., Haruna, A.-U., & Muhammad, A. (2025). Hepatoprotective effect of ethanolic leaves extract of Musa paradisiaca on CCl₄-induced hepatotoxicity in albino rats. Asian Journal of Science, Technology, Engineering, and Art, 3(2), 456–466. https://doi.org/10.58578/ajstea.v3i2.5132
Hassan, A., Alam, O., Tukur, M., Muazu, A. S., & Yusuf, A. J. (2022). Phytochemical, toxicological and in vitro antifungal studies of Mitracarpus hirtus L. Plant Biotechnology Persa, 4(2), 48–56. https://doi.org/10.52547/pbp.4.2.3
Kwembe, J. T. K., Mbula, J. P., Onautshu, O., Mpiana, P. T., & Haesaert, G. (2020). Antifungal activity on the strain of Lasiodiplodia theobromae and phytochemical study of Ageratum conyzoides and Newbouldia laevis from the Kisangani region/DR Congo. International Journal of Pathogen Research, 5(4), 1–10. https://doi.org/10.9734/IJPR/2020/v5i430138
Namadina, M. M., Mukhtar, A. U., Musa, F. M., Sani, M. H., Haruna, S., Nuhu, Y., & Umar, A. M. (2020). Phytochemical, antifungal and acute toxicity studies of Mitracarpus scaber Zucc. whole plant extracts. ChemSearch Journal, 11(2), 73–81. https://www.ajol.info/index.php/csj/article/view/202413