A Concise Overview of Bacteriophage: An Alternative to Antibiotics
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Page Numbers:
808-820
Digital Object Identifier:
10.58578/ajstea.v2i6.3936
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Authors:
Maryam Ibrahim Musa1, Sabiu Muhammad2 
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Authors retain copyright and grant the journal right of first publication.
Main Article Content
Abstract
This paper relates a concise overview of bacteriophage to serve as an alternative to antibiotics. Antibiotics are meant to kill or inhibit bacteria threatening humans or related biota. Bacteria are able to affect humans or biota due to ability to incite infections. The discovery of antibiotics has been considerably of important to modern medicine until recently when resistance is developing due to evolution and other prevailing forces (such as misuse, abuse, massive use, etc). Therefore, seeking alternative against infectious bacteria is imperative. Phages are viruses that kill bacteria. They are supposed candidates to kill bacteria and combat resistance to antibiotics. The phages are able to specifically invade bacteria, hijacked the host replicating machine, instruct the phage DNA replication, elicit lysis to release upcoming phages. This kills the hosting bacteria. The phages are specific, numerous, and effective. Their use should be enhanced for mankind benefits.
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References
Ahmed, S.M. & Ahmed, S.J. (2022). Bacteriophages an alternative to antibiotics for the treatment of bacterial infections: Systematic general review. Biochemistry and Molecular Biology Journal, 8(107),1-6.
Albrecht, L. M. (2018). Antibiotic Resistance. Selection in the Presence of Metals and Antimicrobials. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1488. 53 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0412-0
Arsene, M.M.J., Joeelle, A.B., Sarra, S., Viktorovna, P.I. et al. (2022). Short review on the potential alternatives to antibiotics in the era of antibiotic resistance. Journal of Applied Pharmaceutical Science, 12(1), 29-40.
Dutta, S., Sarkar M., Poran, K., Deka, C. & Sonowal, P.J. (2021). Bacteriophage therapy to combat antibiotic resistance: A brief review. The Pharma Innovation Journal, 10(5), 389-394.
Fowoyo P. (2024). Phage Therapy: Clinical Applications, Efficacy, and Implementation Hurdles. Open Microbiol J; 18: e18742858281566. http://dx.doi.org/10.2174/0118742858281566231221045303
Fowoyo, P.T. (2024). Phage therapy: Clinical applications, efficiency, and implementation hurdles. The Open Microbiology Journal, 3(18),12-33.
Garba, S., Dikko, M., Bala, B.I., Malami, Z. & Sarkingobir, Y. (2024). Surveyed Determinants of rotavirus among diarrheal children 90-5yrs) attending some health facilities in Sokoto Town, Nigeria. Kashmir Journal of Science, 3(1), 55-67.
Kenneth Ssekatawa, Denis K. Byarugaba, Charles D. Kato, Eddie M.Wampande, Francis Ejobi, Robert Tweyongyere & Jesca L. Nakavuma (2021) A review of phage mediated antibacterial applications, Alexandria Journal of Medicine, 57:1, 1-20, DOI:10.1080/20905068.2020.1851441
Khameneh, B.; Eskin, N.A.M.; Iranshahy, M.; Fazly Bazzaz,B.S. (2021). Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria. Antibiotics 2021, 10, 1044. https://doi.org/10.3390/antibiotics10091044
Lusiak-Szelachowska, M., Miedzgbrodzki, R., Drulis-kawa, Z., Cater, K. et al., (2022). Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far. Journal of Biomedical Science, 29(23),1-17.
Megha, G.K., Sumana, M.N. & Mehale, R.P. (2024). Bacteriophage therapy; Unleashing the potential of bacteriophages in modern medicine. Journal of Medicinal and Pharmaceutical Chemistry Research, 7(2025), 282-300.
Mobarki, N.S., Almerabi, B.A. & Hattan, A.H. (2019). Antibiotic resistance crisis. International Journal of Medicine in Developing Countries, 3(6), 561-564.
Moorlag, A.T.M. (2023). Bacteriophages as alternative to antibiotics: A review of therapeutic potential in the face of practical and regulatory challenges. Bachelor Thesis Submitted at University of Groningen.
Pundir, R.K. (2020). Bacteriophage therapy: An alternative to antibiotic therapy. s Immunology Journal, 4(1),1-2.
Romero-Calle, D., Benevide, S., Goes-Neto, A. & Billington, C. (2019). Bacteriophage asalternatives to antibiotics in clinical care. Antibiotics, 8(138),1-20.
Sarkingobir, Y., Hamza, A., Dikko, M., Abubakar, M., Yabo, A.G., & Muhammad, B.I. (2022). Antibacterial study of guava leaves on some enteric bacteria (E. coli and Shigella dysentriae) from Sokoto, Nigeria. International Research Journal of Science, Technology, Education, and Management, 2(4), 1-7.
WHO (2015). Antimicrobial resistance.
Xi, L., He, Y., Wang, J., Hu, T., Si, J. et al., (2021). A combination therapy of phages and antibiotics: Two is better than one. International Journal of Biological Sciences, 17(13)3673-3582.