Antibacterial Effect of Methanol Extract of Newbouldia laevis Leaves on Some Selected Resistant Pathogen on Synthesised Drugs

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Page Numbers: 64-75
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Published: Jul 19, 2024
Digital Object Identifier: 10.58578/kijst.v1i1.3399
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Authors:
Kerenhappuch Isaac Umaru1, Egeonu Stephen Ugoeze2, Akafa Andes Tansaba3, Chakfa Nanmar4, Tyem Lawal Danjuma5, Isaac John Umaru6
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Kerenhappuch Isaac Umaru
Saint Monica University Higher Institute Buea, South West Cameroon, Cameroon
Egeonu Stephen Ugoeze
Federal University Wukari, Taraba State, Nigeria
Akafa Andes Tansaba
Federal University Wukari, Taraba State, Nigeria
Chakfa Nanmar
Federal University Wukari, Taraba State, Nigeria
Tyem Lawal Danjuma
Federal University Wukari, Taraba State, Nigeria
Isaac John Umaru
Federal University Wukari, Taraba State, Nigeria

Abstract

Newbouldia laevis is a tropical plant belonging to the family of Bignoniaceae. It is among the most useful plants in Africa. Historically medicinal plants have been provided a good source of inspiration for novel therapeutic drugs which has made a large contribution to health and well-being of humans. It has been used over the years to as curative agents against many infections and have been exploited in the traditional medicine with their curative potentials. Material and methods: The leaves of Newbouldia laevis was bought from a local market in Wukari, Taraba State. The leaves of Newbouldia laevis was chop into pieces, air-dried for four days and then pulverized into fine powder. About 250 g of the powdered bark extracted with 2 L of ethanol using maceration method for 72 hrs. The crude extracts of Newbouldia laevis was used in antibacterial assay. The results observed demonstrate that the Newbouldia leaves methanol crude extract possesses concentration-dependent antibacterial activity against both Gram-positive resistant bacteria (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria. The increasing inhibition zones with higher concentrations suggest a potential dose-response relationship.

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Article Details

How to Cite
Umaru, K. I., Ugoeze, E. S., Tansaba, A. A., Nanmar, C., Danjuma, T. L., & Umaru, I. J. (2024). Antibacterial Effect of Methanol Extract of Newbouldia laevis Leaves on Some Selected Resistant Pathogen on Synthesised Drugs. Kwaghe International Journal of Sciences and Technology, 1(1), 64-75. https://doi.org/10.58578/kijst.v1i1.3399

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Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

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