Effects of Brassica oleraceae Leaves on Serum Liver Function of Wistar Rats Intoxicated with Prednisolone

Page Numbers: 396-404
Published: 2024-07-31
Digital Object Identifier: 10.58578/ajstm.v1i1.3692
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  • Ananias Amen Federal Polytechnic Bali, Taraba State, Nigeria
  • Dawoye Yusufu Federal Polytechnic Bali, Taraba State, Nigeria
  • Gloria Omonefe Oladele Family Medicine Federal Medical Centre Bida Niger State. Nigeria
  • Kerenhappuch Isaac Umaru Saint Monica University Higher Institute Buea, South West Cameroon, Cameroon

Abstract

The recent study investigated the effects of ethanol extract of Brassica oleracaeae leaves on prednisolone induced toxicity in male albino rats. Liver markers were assayed in order to investigate the toxic effect of prednisolone and the ameliorating effects of the extract. Sixteen (16) rats grouped in to four (n=4) were administered prednisolone and ethanol leaves extract based on the experimental design. The male albino rats were sacrificed after the experimental period of fourteen (14) days, blood was collected for assay of the liver function by ocular puncture. Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) levels were significantly (p<0.05) increased from 5.67 ± 5.13 and 6.67 ±7.02 to 26.67 ± 8.02 and 25.00 ± 4.00 respectively when rats where administered with prednisolone toxicity. Upon treatment of rats with ethanol leaves extract of B. oleraceae at 100mg/kg, the concentration of AST and ALT were lowered to 7.67 ± 6.81 and 8.00 ± 7.55 respectively. A further increased in the concentration of the extract to 300mg/kg resulted to a significant (p<0.05) increased of AST (9.33 ± 8.12) and ALT (12.00 ± 10.00) levels. Similarly, the levels of alkaline phosphatase (ALP) and Albumin increases in the group that were administered with prednisolone however, when rats were treated with ethanol leaves extract of Brassica oleracaeae such concentrations were decreased. The findings of this study can be concluded that, the ethanol leaves extract of Brassica oleracaeae showed capacity in ameliorating the effects induced by prednisolone intoxication.

Keywords: Ethanol extract; Brassica oleracea; Prednisolone toxicity; Male albino rats
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Amen, A., Yusufu, D., Oladele, G. O., & Umaru, K. I. (2024). Effects of Brassica oleraceae Leaves on Serum Liver Function of Wistar Rats Intoxicated with Prednisolone. African Journal of Sciences and Traditional Medicine, 1(1), 396-404. https://doi.org/10.58578/ajstm.v1i1.3692

References

Mohammed, F. S., Günal, S., Pehlivan, M., Doğan, M., Sevindik, M., and Akgül, H. (2020). Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi University Journal of Science. 33(4), 670-677.
Mohammed, F. S., Sevindik, M., Uysal, I., Sevindik, E., and Akgül, H. (2022). A Natural Material for Suppressing the Effects of Oxidative Stress: Biological Activities of Alcea kurdica. Biology Bulletin, 49(Suppl 2), S59-S66.
Sevindik, M., Akgul, H., Pehlivan, M., and Selamoglu, Z. (2017). Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresen Environ Bull, 26(7), 4757- 4763.
Bose, T. K and Som, M. G. (1993). Vegetable crops in India (1sted.). Nayaprakash, Calcutta, 138-150.
Rana, M.K. (2008). Olericulyure in India. Kalyani publishers Ludhiana, 551p.
Gowda, S., Desai, P.B., Hull, V.V., Math, A.A.K., Vernekar, S.N. and Kulkarni, S.S. (2009). A review on laboratory liver function tests. Pan Afr. Med. J. 9(11): 321 – 322.
Reitman, S. and Frankel, D. (1957): A colometric method of determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. American Journal of pathology. 28. 56 – 62.
Babson, L.A., Greeley, S.J., Coleman, C.M. and Phillips, G.D. (1966). Phenolphthalein monophosphate as a substrate for serum alkaline phosphatase. Clinical Chemistry. 12: 482- 490.
Yakubu, O.E., Obot, A.C. and Dawoye, Y. (2016). Effects of Aqueous Extract of Hymenocardia acida Leaves on Aluminium Chloride-Induced Toxicity in Male Albino Rats. Journal of Analytical and Pharmaceutical Research. 3(2): 49.
Crook, M.A. (2006). Clinical Chemistry and Metabolic Medicine. (7th ed.), Hodder Arnold, London, UK, pp. 42
Patrick-iwuuanyanwu, K.C, Wegwu, M.O, and Okiyi, J.K. (2010). Hepatoprotective effects of African locust beans and negro pepper in (CCl4) induced liver damage of Wistar albino rats. International journal of pharmacology, 6(5): 744-749
Yakubu, O.E., Umaru, J., David, A.A., Zephaniah, H.S., Gabriel, S., Jonah, T., David, G., Tsojon, Z.T., and Bando, C.D. (2024). Hepatoprotective effects of fractions of Adansonia digitata leaves on carbon tetrachloride-induced toxicityin Wistar rats. Asian journalof Sciences, Technology, Engineering and Art, 2(2): 243-263.
Adewale, O.B., Akintayo, C.O, Onikanni, A., and Sabiu, S. (2014). Carbon tetrachloride (CCl4)-induced hepatic damage in experimental sprague Dawley rats: Antioxidant potential of xylopia aethiopica. The journalof phytopharmacology, 3(2): 118-123.
Sa’id, A.M., Musa, A.H., Mashi, J.A., Maigari, F.U., and Huhu, M.N. (2020). Phytochemical screening and the patoprotective potential of aqueous fruit pulp Extract of Adansonia digitata against CCl4-induced liver damage in rats. Asian journal of Biochemistry, Genetics and molecular Biology, 3(3): 12-21.
Usunobun, U., Osaigbovo, J.O, and Okolie, N.P. (2020). Hepatoprotective and Antioxidant Effect of Rbaphiostylis beninsis Ethanol Root Extract on carbon tetrachloride (CCl4)-induced Hepatotoxicity and oxidative stress. Annual research international, 17(2): 3781-3789.
Yusufu, D., Grace, N.O, and Henry, A.O. (2021). Effects of Moringa oleifera seeds on serum electrolytes of Wistar rats intoxicated with Aluminium chloride, Tropical journal of natural product research, 5(5): 928-931.

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