Haematological Studies of the Effects of Nauclea Latifolia Ethanolic Root Extracts in Rats
Digital Object Identifier:
10.58578/ajstm.v1i1.3492
Article Metrics:
Viewed : 18 times
Downloaded : 13 times
Viewed : 18 times
Downloaded : 13 times
Article can trace at:
Author Fee:
Free Publication Fees for Foreign Researchers (0.00)
Connected Papers:
Please do not hesitate to contact us if you would like to obtain more information about the submission process or if you have further questions.
Abstract
Nauclea latifolia (Smith) (Family: Rubiaceae) also known as ‘Pin Cushion tree’ or ‘African Peach’ is a struggling shrub, native in tropical Africa and Asia where the use of folk medicine is preval_ent and the search for herbal cure is but common practise. Extraction of the root of Nauclea latifolia with ethanol yielded the ethanol extract. The effects of the ethanolic extract of N. latifolia on haematological parameters showed a significant elevation (p < 0.05) in packed cell volume (PCV), white blood cell count, haemoglobin concentration, red blood cell count and the white blood cell differentials compared to the control group which could be protective mechanisms against infections.
Keywords:
Haematology; Nauclea latifolia; Haemoglobin; Ethanolic Extract and Toxicity; White Blood Cells; Packed Cell Volume (PCV)
Share Article:
Citation Metrics:
Downloads
Download data is not yet available.
How to Cite
C, U. S. M., N, O. V., E, Y. O., J, P. E., S, E., E, A., P, U. O., M, U. C., J, I. T., & J, D. (2024). Haematological Studies of the Effects of Nauclea Latifolia Ethanolic Root Extracts in Rats. African Journal of Sciences and Traditional Medicine, 1(1), 143-156. https://doi.org/10.58578/ajstm.v1i1.3492
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
References
Akpanabiatu, M. I., Umoh, I. B., Udosen, E. O., Udoh, A. E. & Edet, E. E. (2005). Rat serum electrolytes, lipid profile and cardiovascular activity on Nauclea latifolia leaf extract administration. Indian Journal of Clinical Biochemistry, 20: 29-34.
Al-Mamary, M. A. (2002). Antioxidant activity of commonly consumed vegetables in Yemen. Malaysian journal of nutrition, 8(2): 179-189.
Anthonia, O. C., Ikechukwu, U. R., Uzoma, N. O. & Sunday, E. L. U. (2019). Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Biomed Res, 30(4): 645-654.
Awodu, O. A., Enosolease, M. E., Ubaru, A. G. & Famodu, A. A. (2002). Leucocyte counts in pregnant Nigerian women with sickle cell trait. African Journal of Reproductive Health, 112-116.
Bendich, A. (1993). Physiological role of antioxidants in the immune system. Journal of dairy science, 76(9): 2789-2794.
Bin-Jaliah, I., Dallak, M. A., Al-Hashem, F. H., Nwoye, L. O., Sakr, H. F., Jamil, A. M. & Al-Khateeb, M. (2014). Derangement of hemopoiesis and hematological indices in Khat (Catha edulis)-treated rats. African Journal of Biotechnology, 13(2).
Diallo, A., Gbeassor, M., Vovor, A., Eklu-Gadegbeku, K., Aklikokou, K., Agbonon, A., ... & Akpagana, K. (2008). Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats. Fitoterapia, 79(5): 332-336.
Gidado, A., Ameh, D. A. & Atawodi, S. E. (2005). Effect of Nauclea latifolia leaves aqueous extracts on blood glucose levels of normal and alloxan-induced diabetic rats. African Journal of Biotechnology, 4(1): 91-93.
Imoru, J. O., Eno, A. E., Unoh, F. B., Nkanu, E. E., Ofem, O. E. & Ibu, J. O. (2005). Haematopoietic agent (s) in the crude extract from the leaves of Viscum album (Mistletoe). Nigerian Journal of Health and Biomedical Sciences, 4(2): 139-145.
Iwu, M. W., Duncan, A. R. & Okunji, C. O. (1999). New antimicrobials of plant origin. Perspectives on new crops and new uses. ASHS Press, Alexandria, VA, 457, 462.
Mukinda, J. T. & Syce, J. A. (2007). Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. Journal of ethnopharmacology, 112(1): 138-144.
Ogbe, R. J., Adoga, G. I. & Abu, A. H. (2010). Antianaemic potentials of some plant extracts on phenyl hydrazine-induced anaemia in rabbits. Journal of Medicinal Plants Research, 4(8): 680-684.
Okoli, A. S. & Iroegbu, C. U. (2004). eval_uation of extracts of Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii for activity against bacterial isolates from cases of non-gonococcal urethritis. Journal of ethnopharmacology, 92(1): 135-144.
Oso, B. J., Oyewo, E. B. & Oladiji, A. T. (2019). Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Rich on haematological and biochemical parameters in healthy Wistar rats. Clinical Phytoscience, 5: 1-10.
Owolabi, O. J., Nworgu, Z. A. M. & Odushu, K. (2010). Antidiarrheal eval_uation of the ethanol extract of Nauclea latifolia root bark. Methods and Findings in Experimental and Clinical Pharmacology, 32(8): 551-555.
Stover, P. J. & Caudill, M. A. (2008). Genetic and epigenetic contributions to human nutrition and health: managing genome–diet interactions. Journal of the American Dietetic Association, 108(9): 1480-1487.
TchuifonTchuifon, D., Fu, H. Z. & Ho, Y. S. (2017). Cameroon publications in the science citation index expanded: bibliometric analysis. Revista de Biología Tropical, 65(4), 1582-1591.
Tian, X. R., Feng, G. T., Ma, Z. Q., Xie, N., Zhang, J., Zhang, X. and Tang HF (2014). Three new glycosides from the whole plant of Clematis lasiandra Maxim and their cytotoxicity. Phytochemistry Letters, 10: 168-172.
Udobi, C., Umoh, B., & Asuquo, E. G. (2017). Effects of the ethanol extract of the stem bark of Nauclea latifolia Smith [Rubiaceae] on certain biochemical and haematological indices of Swiss Albino Mice. Asian Journal of Medicine and Health, 6(1): 1-9.
Udobre, A. S., Etim, E. I., Udobang, J. A., Udoh, A. E., Akpan, A. E. and Ekpo, N. A. (2013). Antiplasmodial effect of the methanol extract of the stem bark of Nauclea latifolia. Indo American Journal of Pharmaceutical Research, 3: 6484–6489.
Valdez-Solana, M. A., Mejía-García, V. Y., Téllez-Valencia, A., García-Arenas, G., Salas-Pacheco, J., Alba-Romero, J. J. & Sierra-Campos, E. (2015). Nutritional content and elemental and phytochemical analyses of Moringa oleifera grown in Mexico. Journal of Chemistry, 2015(1): 860381.
Varsha, S., Agrawal, R. C. & Sonam, P. (2013). Phytochemical screening and determination of anti-bacterial and anti-oxidant potential of Glycyrrhiza glabra root extracts. Journal of environmental Research and Development, 7(4A): 1552.
Yakubu, O. E., Otitoju, O., Arowora, K. A. and Imo C. (2017). Biochemical Changes in Haematological and Liver Function Parameters in Intoxicated Male Albino Rats Treated with Hymenocardia acida Leaves Ethanolic Extract; Insights in Biomedicine, 2(2): 10
Al-Mamary, M. A. (2002). Antioxidant activity of commonly consumed vegetables in Yemen. Malaysian journal of nutrition, 8(2): 179-189.
Anthonia, O. C., Ikechukwu, U. R., Uzoma, N. O. & Sunday, E. L. U. (2019). Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Biomed Res, 30(4): 645-654.
Awodu, O. A., Enosolease, M. E., Ubaru, A. G. & Famodu, A. A. (2002). Leucocyte counts in pregnant Nigerian women with sickle cell trait. African Journal of Reproductive Health, 112-116.
Bendich, A. (1993). Physiological role of antioxidants in the immune system. Journal of dairy science, 76(9): 2789-2794.
Bin-Jaliah, I., Dallak, M. A., Al-Hashem, F. H., Nwoye, L. O., Sakr, H. F., Jamil, A. M. & Al-Khateeb, M. (2014). Derangement of hemopoiesis and hematological indices in Khat (Catha edulis)-treated rats. African Journal of Biotechnology, 13(2).
Diallo, A., Gbeassor, M., Vovor, A., Eklu-Gadegbeku, K., Aklikokou, K., Agbonon, A., ... & Akpagana, K. (2008). Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats. Fitoterapia, 79(5): 332-336.
Gidado, A., Ameh, D. A. & Atawodi, S. E. (2005). Effect of Nauclea latifolia leaves aqueous extracts on blood glucose levels of normal and alloxan-induced diabetic rats. African Journal of Biotechnology, 4(1): 91-93.
Imoru, J. O., Eno, A. E., Unoh, F. B., Nkanu, E. E., Ofem, O. E. & Ibu, J. O. (2005). Haematopoietic agent (s) in the crude extract from the leaves of Viscum album (Mistletoe). Nigerian Journal of Health and Biomedical Sciences, 4(2): 139-145.
Iwu, M. W., Duncan, A. R. & Okunji, C. O. (1999). New antimicrobials of plant origin. Perspectives on new crops and new uses. ASHS Press, Alexandria, VA, 457, 462.
Mukinda, J. T. & Syce, J. A. (2007). Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. Journal of ethnopharmacology, 112(1): 138-144.
Ogbe, R. J., Adoga, G. I. & Abu, A. H. (2010). Antianaemic potentials of some plant extracts on phenyl hydrazine-induced anaemia in rabbits. Journal of Medicinal Plants Research, 4(8): 680-684.
Okoli, A. S. & Iroegbu, C. U. (2004). eval_uation of extracts of Anthocleista djalonensis, Nauclea latifolia and Uvaria afzalii for activity against bacterial isolates from cases of non-gonococcal urethritis. Journal of ethnopharmacology, 92(1): 135-144.
Oso, B. J., Oyewo, E. B. & Oladiji, A. T. (2019). Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Rich on haematological and biochemical parameters in healthy Wistar rats. Clinical Phytoscience, 5: 1-10.
Owolabi, O. J., Nworgu, Z. A. M. & Odushu, K. (2010). Antidiarrheal eval_uation of the ethanol extract of Nauclea latifolia root bark. Methods and Findings in Experimental and Clinical Pharmacology, 32(8): 551-555.
Stover, P. J. & Caudill, M. A. (2008). Genetic and epigenetic contributions to human nutrition and health: managing genome–diet interactions. Journal of the American Dietetic Association, 108(9): 1480-1487.
TchuifonTchuifon, D., Fu, H. Z. & Ho, Y. S. (2017). Cameroon publications in the science citation index expanded: bibliometric analysis. Revista de Biología Tropical, 65(4), 1582-1591.
Tian, X. R., Feng, G. T., Ma, Z. Q., Xie, N., Zhang, J., Zhang, X. and Tang HF (2014). Three new glycosides from the whole plant of Clematis lasiandra Maxim and their cytotoxicity. Phytochemistry Letters, 10: 168-172.
Udobi, C., Umoh, B., & Asuquo, E. G. (2017). Effects of the ethanol extract of the stem bark of Nauclea latifolia Smith [Rubiaceae] on certain biochemical and haematological indices of Swiss Albino Mice. Asian Journal of Medicine and Health, 6(1): 1-9.
Udobre, A. S., Etim, E. I., Udobang, J. A., Udoh, A. E., Akpan, A. E. and Ekpo, N. A. (2013). Antiplasmodial effect of the methanol extract of the stem bark of Nauclea latifolia. Indo American Journal of Pharmaceutical Research, 3: 6484–6489.
Valdez-Solana, M. A., Mejía-García, V. Y., Téllez-Valencia, A., García-Arenas, G., Salas-Pacheco, J., Alba-Romero, J. J. & Sierra-Campos, E. (2015). Nutritional content and elemental and phytochemical analyses of Moringa oleifera grown in Mexico. Journal of Chemistry, 2015(1): 860381.
Varsha, S., Agrawal, R. C. & Sonam, P. (2013). Phytochemical screening and determination of anti-bacterial and anti-oxidant potential of Glycyrrhiza glabra root extracts. Journal of environmental Research and Development, 7(4A): 1552.
Yakubu, O. E., Otitoju, O., Arowora, K. A. and Imo C. (2017). Biochemical Changes in Haematological and Liver Function Parameters in Intoxicated Male Albino Rats Treated with Hymenocardia acida Leaves Ethanolic Extract; Insights in Biomedicine, 2(2): 10
