Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer

Page Numbers: 471-479
Published: 2024-07-28
Digital Object Identifier: 10.58578/ajbmbr.v1i1.3487
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  • Isaac John Umaru Federal University Wukari, Taraba State, Nigeria
  • Otitoju Olawale Federal University Wukari, Taraba State, Nigeria
  • Emmanuel Chikodiri Okoli Federal University Wukari, Taraba State, Nigeria
  • Akafa Andes Tensaba Federal University Wukari, Taraba State, Nigeria
  • Kerenhappuch Isaac Umaru University of Higher Institute Buea, South West Cameroon, Cameroon
  • Dafup Kadel Istifanus Federal University Teaching Hospital, Uburu, Ebonyi State Nigeria
  • David Umahi Federal University Teaching Hospital, Uburu, Ebonyi State Nigeria

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.

Keywords: Ameliorative; Stem Bark; Extract; Pterocarpus Erinaceus; Indomethacin; Induced; Ulcer
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Umaru, I. J., Olawale, O., Okoli, E. C., Tensaba, A. A., Umaru, K. I., Istifanus, D. K., & Umahi, D. (2024). Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer. African Journal of Biochemistry and Molecular Biology Research, 1(1), 471-479. https://doi.org/10.58578/ajbmbr.v1i1.3487

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