A. Sativum in the Prevention of Schistosomiasis in Sokoto, Nigeria: Evaluation of Phytochemical Contents, Acute Toxicity, and Effect on Some Kidney Function Parameters in Rats
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10.58578/mikailalsys.v1i2.1542
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Abstract
Schistosomiasis is an infectious disease of public health importance in the African countries. Due to poor prevention, poverty, and poor settings; areas like Sokoto, Nigeria are battling with the disease. Consequently, people are compelled to use preventive measures locally. There is recorded use of A. sativum for the prevention of schistosomiasis without enough scientifically supported information in that regards. Therefore, this work evaluated phytochemicals, acute toxicity, and subchronic toxicity (effects on some kidney indices). Standard methods and reagents of analytical grade were utilized. The work reveals the presence of some phytochemicals, no acute toxicity (at 4000 mg/kg body weight), as well as no major change in the urea, uric acid, and creatinine levels. 1.111 mg/dl to 1.118 mg/dl creatinine, 1.011 mg/dl to 1.025 mg/dl urea, and 1.120 mg/dl to 1.140 mg/dl uric acid were determined in control and highest dose (4000 mg/kg body weight) (p<0.05). This indicates that, the plant is likely to elicit little effects on the experimental animals. Much work is important to evaluate sufficiently the safety of the A. sativum in prevention of Schistosomiasis in the Sokoto, Nigeria.
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References
Akinneye, J.O., Fasidi, M.M., Afolabi, O.J., & Adesina, F.P. (2018). Prevalence of urinary schistosomiasis among secondary school students in Ifedore Local Government, Ondo state, Nigeria. International Journal of Tropical Diseases, 1(1), 1-6.
Anthony, D., Emmanuel, B., Blessing, J.N., Enock, L., & David, Y.P. (2019). Schistosomiasis among primary school pupils in Pilagani District, Langtang North Local Government Area, Plateau State, Nigeria. GSC Biological and Pharmaceutical Sciences, 9(1), 5-14.
Anyolitho, M.K., Pels, K., Hyyse, T., Tumusiime, J., etal (2022). Knowledge, attitudes, and practices regarding schistosomiasis infection and prevention A mixed methods study among endemic communities of western Uganda; Plos Neglected Tropical Diseases, 16 (2), 1-10.
Aula, O.P., McManus, D.P., Jones, M.K., & Gordon, C.A. (2021). Schistosomiasis with a focus on Africa. Tropical Medicine and Infectious Diseases, 6(109), 1-40.https://doi.org/10.3390/tropicalmed6030109.
Dawaki, S., Al-mekhlafi, H., M. Ithio, I., Ibrahim, Abdulsalam, A.M., Ahmed, A. etal (2015). The menace of schistosomiasis in Nigeria knowledge, attitudes and practices regarding schistosomiasis among rural communities Kano state. Plos ONE, 10 (1) -1-14.
Dawaki, S., Al-mekhlati, H.M., Ithoi, L., Ibrahim, J., Abdulsalam, A.M., Ahmed, A. etal, (2016). Prevalence and risk factors of schistosmiasis among Hausa communities in Kano state, Nigeria Review. Lastest Medicine in Tropical Sao Paulo, 58 (54),1-9
Dikko, M., Sarkingobir, Y., & Umar A.I. (2020). Effect of Tamsulosin use on fasting blood glucose and plasma insulin levels in normal Wistar rats. Adamawa state Journal of Scientific Research, 8(2): 81-84.
Gamde, S.M., Garba, A., Tongvwam, P., Gamde, S.D., Agom, D.D., & Igbinosa, I.(2022). Prevalence, intensity, and risk factors of urinary schistosomiasis among primary school children in Silame, Sokoto, Nigeria. Microbes and Infectious Diseases, 4(2), 695-703.
Hamburg, S.D., Grobler, A.D., and Melarin, P.E. (2021). Knowledge, attitudes and practices on urinary schistosomiasis among Mandek Bay south. Africa Journal of Parasitology Research 2021-1-12.
Jibia, A.B. & Sani, Z.R. (2019). Intensity of urinary schistosomiasis associated with gender-agedgroup of primary schools children in Sokoto south and Kware area, Sokoto state, Nigeria. International Journal of Science for Global Sustainability, 5(1), 54-64.
Johnbull, D., Panda, S.M., & Samaila, A.B. (2021). Epidemiological study of schistosomiasis in Basiraka, Gwaran local government area, Jigawa state Nigeria. Science Forum (Journal of Pure and Applied Sciences) 21, 144-157.
Lawal, A., & Matazu, S.S.(2015). Comparative studies of white and red Allium cepa cultivated in Sokoto, Nigeria. ChemSearch Journal, 6(2), 14-20.
Lawal, B., Shiitu, O.K., Oibiokpa, F.J., Mohammed H., Umar, S.I., & Haruna, G.M.(2016). Antintimicrobial evaluation, acute and subacute toxicity studies of A. sativum. Journal of Acute Disease, 5(4), 296-301.
Mana, U.A., Bunza, M.D.A., Attah, D.D., & Sani, I., (2022). Ethnobotanical survey of some medicinal plants used in the treatment of schistosomiasis in Sokoto metropolis, Sokoto state, Nigeria. Chalipahte Journal of Science and Technology, 1,33-39.
Mikhail, H.G. (2010). Phytochemical screening, elemental analysis of A. sativum l. bulbs in experimental rabbits. Journal; of Medicinal Plants Research, 4(4), 322-326.
Mohammad, M., Umar, A.Y,, Vantsawa, P.A., Mukhtar, M.D., & Hassan, R.(2020). Influence of urinary schistosomiasis om nutritional status in Almajiri (disciples) in Kawo District of Kaduna metropolis, Kaduna state-Nigeria. IRDO Journal of Health Sciences and Nursing, 8(12), 38-44.
Mohammed, M., Vantsawa, P.A., abdullahi, U.Y., & Mukhtar, D. (2015). Nutritional status and prevalence of intestinal schistosomiasis among Almajiri population in Kawo Kawo District of Kaduna metropolis, Kaduna state-Nigeria. Journal of Bacteriology and Parasitology, 6(4), 1-5.
Muhammad, S., Hassan, L.G., Dangoggo, S.M., Hassan, S.W., Umar, K.J., & Aliyu, R.U.(2011). Acute and subchronic toxicity studies of kernel extracts of Schlerocarya in rats. Science World Journal, 6930, 11-14.
Nelwan, M.L. (2019). Schistosomiasis life cycle, diagnosis and control. Current Therapeutic Research, (2019), 5-9.
Nelwan, M.L. (2019). Schistosomiasis Life cycle, diagnosis, and control. Current Therapeutic Research, 91, 5-9. Htps://doi.org/10.1016/j.curtheres.2019.06.001.
Noorshilawati, A.A., Nur Suraya, A. & Rosssiyah, S. (2020). Moluscicidal activity of Ipomea batatas leaf extracts against Pomacea canaliculata (Golden apple snail). Food Research, 5(5), 131-137.
Oyeyemi, O.T., Jeremias, W.J., & Grenfell, R.F.G. (2020). Schistosomiasis in Nigeria: Gleaning from the past to improve current efforts towards control. One Health, 11(100183), 1-10.
Pavni, K., Esha, B., Neha, J., Tushar, A.Shrey, K., Suchit,A.,Sarita, A.,Vibha,R., & Neeraj,W. (2011). Journal of Pharmacy Research, 4 (3), 902-908.
Rinaldo, D., Perez-Saez, J., Vounatsou, P., Utzinger, J., & Archand, J. (2021). The economic impact of schistosomiasis. Infectious Diseases of Poverty, 10(134), 1-12.https://doi.org/10.1186/s40249-021-00919-z.
Sady, H., Al-mekhlafi, H.M. Atroosh, W.M., Al delaimy, A.K etal (2015). Knowledge, attitudes and practices towards schistosomiasis among rural population in Yemen. Parasites,8 (436), 1-14.
Sarkingobir, Y., Hiliya, A.A., Miya, Y.Y., Umar, A.I., Yabo, A.M., & Salah, N.M. (2023a). Some metals contained in well drinking water obtained from some secondary schools in Schools in Sokoto East District, Nigeria. Journal of Community Service in Science and Engineering, 2(1), 15-24. Doi: 10.36055/jocse.v2i1.19802.
Sarkingobir, Y., Umar, AI., Gidadawa FA., & Miya, Y.Y. (2023b). Assessment of food security, living condition, personal hygiene health determinants and relations among Almajiri students in Sokoto metropolis, Nigeria. Thu Dau Mot Journal of Science, 5(1),63-76. https://doi.org/10.37550/tdmu.EJS/2023.01.372. ISSN: 2615-9635. Publisher: Thu Dau Mot University Vietnam. https://ejs.tdmu.edu.vn.Home
Suleiman, J., Singh K., Bala A.Y., Muhammad, M.T. & Yakubu, M.S. (2018b). Molluscicidal potential of column purified fractions of Allium cepa bulbs against intermediate host of urinary schistosomiasis (Bulinus globosus) in Sokoto, Nigeria. Asian Journal of Research in Zoology, 1(1), 1-6.
Suleiman, J., Singh K., Bala A.Y., Muhammad, M.T., Abdullahi, A., & Yakubu, M.S. (2018a). Comparison for the effectiveness of column purified fractions of Allium cepa bulbs and Allium sativum cloves against Bulinus globosus (intermediate host of urinary schistosomiasis) in Sokoto, Nigeria. Asian Journal of Advanced Research and Reports, 2(4), 1-6.
Suleiman, M., Ahmed, A., & Gobir, S.S. (2022). Haemo and gastrointestinal parasites in cattle slaughtered at Gwadabawa abattoir in Sokoto state, Northwestern Nigeria. The Bioscientist, 10(1), 55-64.
Umoh, N.O., Nwamini, C.F., Inyang N.J., etal. (2020). Prevalence of urinary schistosomiasis amongst primary school children in Ikwo and Ohaukwu communities of Ebonyi State, Nigeria. African Journal of Laboratory Medicine, 9(1), 1-5.https://doi.org/10.4102/ajlm.v9i1.812.
