Synthesis and Preliminary Antibacterial Screening of Hydrazone Derived from Isonicotinic Acid Hydrazide and Its Cu(II), Co(II) and Ni(II) Complexes
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10.58578/amjsai.v1i1.3753
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Abstract
Complexes of Cu(II), Co(II) and Ni(II) derived from the ligand Acetone isonicotinic acid hydrazone (AINH) have been synthesized and characterized on the basis of electronic and physico-chemical methods. The results indicate that all complexes exhibited coordination number of 6 and the ligand coordinated to metal via N and O donor. Analytical data reveal that all the complexes possess 1:2 metal–ligand ratios. Molar conductivity measurements showed non-electrolytic nature of the complexes while the solubility test on the ligand and its metal(II) complexes showed they are soluble in dimethylsulphoxide (DMSO). The complexes were eval_uated for their antibacterial activity against human pathogens like gram positive Staphylococcus aureus (S. aureus), Streptococcus pyogenes (S. pyogenes) and gram negative Escherichia coli (E. coli), Salmonella typhi (S. typhi) strains. The result of microbial screening showed that the complexes have moderate antimicrobial activity.
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References
[2] Amudat, L., (2010). Synthesis, Characterization and Biological Studies of Mixed Vitamins-Metal Complexes. Ph.D. thesis. Department of Chemistry, University of Ilorin, Nigeria. 175 pp.
[3] Behera S. (2009). Cobalt (II) and Nickel (II) Complexes of Aroyl Hydrazone Ligand; Synthesis and Characterization. MSc. thesis. National Institute of Technology, Rourkela. 37 pp.
[4] Dianu, M.L., Angela K., Stãnicã N., Drãghici C. and Popoiu, M. (2009). Synthesis and Characterization of Some Tranzition Metals Complexes with Glyoxal bis- Isonicotinoyl Hydrazone. Revista De Chimie Bucharest, 60(6), 555-560.
[5] Salawu, O.W., Eneji I.S. and Salami, H.A. (2015). Preparation and Spectroscopic Characterization of 2-Ethoxy Isobutryl Acid Hydrazide and 2-ethoxy Isobutrylaceto Hydrazone and its Metal Complexes with Co(II), Ni(II) and Cu(II). International Journal of Inorganic and Bioinorganic Chemistry, 5(2):23-27.
[6] Suvarapu, L. N., Seo, Y.K., Baek, S.O. and Ammireddy, V.R. (2012). Review on Analytical and Biological Applications of Hydrazones and their Metal Complexes. E-Journal of Chemistry, 9(3): 1288-1304.
[7] Bhagat, S.M. and Deshpande, M.N. (2012). Synthesis and Antimicrobial Activity of some Transition Metal Ion Chelates of 2-(cinnamyl)-4-bromo-6-methyl benzothiazolyl Hydrazones. Journal of Chemical and Pharmaceutical Research, 4(3):1454-1456.
[8] Kamalakev, R.K., Sayaji, R. and Biyyala S.R. (2015). Synthesis and Characterization and Biological Activities of Hydrazones. International Journal of Innovative Researchin Science, Engineering and Technology, 4(1), 18944-18952.
[9] Karlin, K.D. and Zubieta, j. (1983). Copper Coordination Chemistry: Biochemistry Chemical and Inorganic Perspectives, Adenine Press Guilderland, New York.
[10] Dnyandeo, M.J., Dingambar D.G., Priyanka, L.A. and Ganesh, S.K. (2015). Efficient Ultrasound Synthesis and Biological Screening of Metal Complexes of N-(4-Methoxybenzylidiene) isonicotinohydrazone. World Journal of Pharmaceutical Research, 5(2), 1153-1161.
[11] Lukov, V.V., Levchenkov, S.I., Posokhova, S.V., Shcherbakov, I.N. and Kogan, V.A. (1990). Effects of Electronic and Steric Factors on the Magnetic Properties of Novel Homo- and Heterobinuclear Transition-Metal Complexes with Asymmetric 2,6-Diformyl-4-R-Phenol Bis(Hydrazones). Russian Journal of Coordination Chemistry, 28(3):222-225.
[12] Mackay, K. M., and Mackey, R. A. (1989). Introduction to Modern Inorganic Chemistry, 4th edition, Butterworth and Co. Ltd. USA, 414-427.
[13] Nakamoto, K. (1992). Infrared and Raman Spectra of Inorganic and Co-ordination Compounds, 3rd edn., John Wiley and Sons, New York, pp. 110.
[14] Lever, A, B. P. (1984). Inorganic Electronic Spectroscopy, Elsevier, Amsterdam.
[15] Anderson, R.J., Bendell, D.J. and Ground water, P.W (2004). Organic Spectroscopic Analysis, Royal Society of Chemistry, 24-27, 51-89.
[16] Casanova, J., Alzuet, G, Ferrer, S, Borras, J. Garcia-Granda, S. and Perez-Carreno, E. (1993). Metal complexes of sulfanilamide Derivatives Crystal structure of (Zn(sulfathiazole)2)H2O). Journal of Inorganic Biochemistry, 51, 689-699.
[17] Ogunniran, K.O., Tella, A.C., Alensa, M. and Yakubu, M.T. (2007). Synthesis, Physical Properties, Antimicrobial Potentials of some Antibiotics complexed with Transition Metals and their Effects on Alkaline Phosphastase Activities of Selected Rat Tissues. African Journal of Biotechnology, 6(10), 1202-1208.
[18] Salawu, O.W. and Abdulsalam, A.O. (2011). Synthesis, Characterization and Biological Activities of Cd(II) Complexes with Hydrazide Ligands. Der Pharma Chemica, 3(4): 298-304.
[19] Salawu, O.W. and Aliyu, O.C. (2012). Synthesis, Spectral Studies of Metal(II) Complexes. Advances in Pure and Applied Chemistry (APAC), 1(1), 1217.
[20] Salawu, O.W., Eneji, I.S. and Fayomi, O.M. (2015). Oxalaceto(2-Chloro–6–Fluoro–Benzylidene) and Oxalaceto(2-Chloro-5–Nitrobenzylidene) Hydrazides and Spectroscopic Studies of the Complexes. Chemistry and Materials Research, 7(3): 100-104.
