Antimycobacterial Activity of Newbouldia laevis Root and Stem Bark Extracts: In Vitro Evaluation and Phytochemical Composition

Crossmark

Article Sidebar

Page Numbers: 1-11
Download PDF
Published: Jul 6, 2024
Digital Object Identifier: 10.58578/ajbmbr.v1i1.3311
Save this to:
Save to Mendeley Download RIS

Article Metrics:
Viewed: 421 times
Downloaded: 284 times
Article can trace at:

Author Fee:
Free Publication Fees for Foreign Researchers (USD 0.00)
Check for article on SINTA:

LYAS Publisher cordially invites qualified professionals to serve as Editors or Reviewers. Your expertise will make an important contribution to maintaining and strengthening the academic quality of our publications. Interested applicants are kindly requested to complete the application form at the following link: Editors & Reviewers

Connected Papers:
Connected Papers


Please feel free to contact us if you need any further information about the submission process or if you have any additional questions.


Authors:
Saleem Sule Zarto1, Sa'ad Sabri Abdul2, Joseph F. Kpesibe3, Saminu Hamman Barau4
Copyright :

Authors retain copyright and grant the journal right of first publication.

Explore Our Journals
Find the journal that best fits your research. If this journal does not match your manuscript’s scope, explore our portfolio below to select a more suitable publication venue.

Main Article Content

Saleem Sule Zarto
Modibbo Adama University of Technology, Yola, Adamawa State, Nigeria
Sa'ad Sabri Abdul
Federal Polytechnic Bali Taraba State, Nigeria
Joseph F. Kpesibe
Taraba State University Jalingo, Taraba State, Nigeria
Saminu Hamman Barau
Adamawa State Polytechnic, Yola, Adamawa State, Nigeria

Abstract

This present study aimed to determine the phytochemical screening, antimicrobial and anti-tuberculosis activity of the root and stem bark of methanol extracts of the N. laevis plant from Gashaka Gumti national park of Taraba state. Phytochemical screening was carried out using standard methods. For the two extracts obtained from the root and stem bark which revealed the presence of all except cardiac glycosides and quinones in the root, while all were the stem bark extracts. The Anti-bacterial assay was carried out using Agar-well diffusion technique. The highest zone of inhibition for the root crude extract of E. coli was (18mm) and its lowest zone of inhibition was (2mm), the highest zone of inhibition of Stap. A was (22mm) and the lowest was (8mm), the highest zone of inhibition of Bacillus cereus (22mm) and its lowest was (10mm). Salmonella typhii had the highest zone of inhibition for the root extract at (24mm) and its lowest at (4mm). The highest zone of inhibition for stem bark crude extract of E. coli was (12mm) and its lowest zone of inhibition was (5mm), the highest zone of inhibition of Stap. A was (13mm) and the lowest was (6mm), the highest zone of inhibition of Salmonella typhii was (18mm) and its lowest was (18mm),the highest zone of inhibition of Bacillus cereus  (12mm) and its lowest was (4mm). The anti- tuberculosis assay was carried out using Broth micro dilution method. The result concerning the mycobacterium TB (anti-tuberculosis) of the root and stem bark crude extract of N. laevis plants inhibit the growth of bacterium with inhibitory zone within the range 6-16mm. This study reveals that the methanolic crude extract of N. laevis root and stembark can be utilized as a potential anti-tuberculosis (TB) drug for novel discovery.

Keywords:
Share Article:

Citation Metrics:

Scopus

Downloads

Download data is not yet available.

Citation Metrics & Similar Scopus Articles

Data source Crossref
1
citations
Citation counts are source-specific and may differ because database coverage, reference matching, and update schedules are different. Counts are not added together. Crossref values represent citation links registered and matched by Crossref.
Check Secondary Documents in Scopus
Open this article in Scopus, then check the Secondary documents tab. Use Manual Citation Fallback only for counts you have verified manually.
Open in Scopus
Similar Scopus Articles
Scopus
  1. Berenjian K. (2027)
    Impact of Mild Traumatic Brain Injury (mTBI) on CYP2D6 Activity and the Restorative Effects of Melatonin and Vitamin C Supplementation
    Iranian Journal of Pharmaceutical Research, 26(1)
  2. Zhang X. (2027)
    Rational Design of Covalent Organic Frameworks for Oxygen Electrocatalysis: Recent Advances and Mechanistic Insights
    Nano Micro Letters, 19(1)
  3. Sheng T. (2027)
    Photothermal Superhydrophobic Textiles: An Emerging Paradigm from Passive Water Repellency to Active Thermal Management
    Nano Micro Letters, 19(1)

Article Details

How to Cite
Zarto, S. S., Abdul, S. S., Kpesibe, J. F., & Barau, S. H. (2024). Antimycobacterial Activity of Newbouldia laevis Root and Stem Bark Extracts: In Vitro Evaluation and Phytochemical Composition. African Journal of Biochemistry and Molecular Biology Research, 1(1), 1-11. https://doi.org/10.58578/ajbmbr.v1i1.3311

Creative Commons License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

References

1. Sahoo, N., Manchikanti, P., &Dey, S. (2010). “Herbal drugs: standards and regulation,” Fitoterapia, 81(6), 462–471.
2. Agbafor, K. N. &Ezeali, C. (2015). Effects of Leaf and Root Extracts of Newbouldialaevison Antioxidant Activity of Polyphenols Extracted from Salvia miltiorrhiza Bunge." Food Chemistry 309: 125691. https://doi.org/10.1016/j.foodchem.2019.125691
3. Shagal, M.H., Kubmarawa., D., Tadzabla.,. k., and DennisK.I., (2012). Evaluation of photochemical and antimicrobial potentials of root, stem-bark and leaves extracts of Eucalyptus camaldulensis. Journal of Pure and Applied Chemistry 6(5), 74-78.
4. Kubmarawa, D., Ajoku, G.A., Enwerem, N.M. & Okorie, D.A. (2007). Preliminary photochemical and antimicrobial screening of 50 medicinal plants from Nigeria from Nigeria. African Journal of Biotechnology, 6(14), 1690-1696
5. Edeoga, H.O., Okeniyi, S.O. & Mbaebie, B.O. (2005). Phytochemical constituents of some Nigeria medicinal plants. African Journal of Biotechnology, 4(7), 685-688.
6. Wakawa, H.Y., Ibrahim, M.E. & Dahiru, D., (2010). Photochemical and antimicrobial screening of selected Anti-Diabetic plants in Nigeria. Agriculture, Business and Technology Journal. 8(2), 56-63.
7. Rajesh, N., Rao, S.N., Rani, M.N., Shetty, P.K., Rejeesh, E.P. & Chandrashekar, R. (2014). Phytochemical analysis of methanolic extract of Curcuma longa Linn rhizome. Int. J. Uni. Pharm. Bio Sci. 2(2), 39-41.
8. Singh, B., et al . (2015) Plants as Future Source of Anti-Mycobacterial Molecules and Armour for Fighting Drug Resistance. Journal of Animal and Veterinary Advances ,10, 443-460. https://doi.org/10.3923/ajava.2015.443.460
9. World Health Organization (2021) Global Tuberculosis Report 2021.
10. Hutchinson J, Dalziel JM. (1963) Flora of West Tropical Africa vol II. London: Crown Agents for Oversea Government and Administration; pp 435-436.
11. Mahomoodally, M. F. (2013) “Traditional medicine in Africa; an appraisal of ten potent Africa medicinal plants”. Evidence-Based complementary and alternative medicine, 2013(617459), 14
12. Mann, A. J. O. Amupitan, A. O. Oyewale, J. I. Okogun, K. Ibrahim , P. Oladosu, L,Lawson, I. Olajide and A. Nnamdi (2008) Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases
13. Osadebe, P O Diejke, CA and Okoye FBC (2008). A study of seasonal variation in the antimicrobial constituents of the leaves of loranthusmicranthus sourced from Persia americana. Research journal of medicinal plant 2(1):i48-52
14. Lata, N. & Dubey, V. (2010). Flavonoids. Journal of Pharm. Res.; 3(6), 1240-1242.
15. Wafaa, G.S., Wael, M.A., Alaa, H.S., Mahmoud, H.S. & Ehab, A.E. (2016). Evaluation of the biological activity of Moringa oleifera leaves extract after incorporating silver nanoparticles, in vitro study, Bulletin of the National Research Centre, 43,2019,212-218.
16. Gupta, R., et al . (2010) Anti-Tuberculosis Activity of Selected Medicinal Plants against MultiDrug Resistant Mycobacterium tuberculosis Isolates. Indian Journalof Medical Research, 131, 809.